Search Results (1,955)

The low aqueous solubility of many new drug candidates, a key challenge in oral drug development, has been effectively addressed by liquid self-emulsifying drug delivery systems (SEDDS). However, the inherent instability and manufacturing limitations of liquid formulations have prompted significant research into solid SEDDS. This review provides a comprehensive analysis of the recent advancements in solid SEDDS, focusing on the pivotal roles of solid carriers and solidification techniques. We examine a wide range of carrier materials, including mesoporous silica, polymers, mesoporous carbon, porous carbonate salts, and clay-based materials, highlighting how their physicochemical properties can be leveraged to control drug loading, release kinetics, and in vivo performance. We also detail the various solidification methods, such as spray drying, hot melt extrusion, adsorption, and 3D printing, and their impact on the final product’s quality and scalability. Furthermore, this review explores applications of solid SEDDS, including controlled release, mucoadhesive technology, and targeted drug delivery, as well as the key commercial challenges and future perspectives. By synthesizing these diverse aspects, this paper serves as a valuable resource for designing high-performance solid SEDDS with enhanced stability, bioavailability, and functional versatility. Full article

This study investigates the potential of porous poly(D,L-lactide) (PDLLA) scaffolds reinforced with graphene oxide (GO) for bone tissue engineering applications. Scaffolds were fabricated using thermally induced phase separation (TIPS) and characterized in terms of morphology, biodegradation, thermal and mechanical properties, and cytocompatibility. The incorporation of GO enhanced both mechanical strength and thermal stability, likely due to hydrogen bonding and electrostatic interactions between GO’s functional groups (carbonyl, carboxyl, epoxide, and hydroxyl) and PDLLA chains. In vitro degradation studies showed that GO accelerated degradation, while scaffolds with higher GO content retained superior mechanical strength. Cytotoxicity assays confirmed the biocompatibility of all scaffold variants, supporting their suitability for biomedical applications. Overall, the findings demonstrate how GO incorporation can modulate scaffold composition and performance. This provides insights for the design of improved systems for bone tissue regeneration. Full article

The rapid expansion of concrete production has intensified the depletion of natural aggregate (NA) resources, necessitating sustainable alternatives in the construction industry. Recycling construction and demolition (C&D) waste offers a solution to enhance environmental sustainability and resource efficiency. Most existing studies have mainly focused on first-generation RCAs (RCA1), with little work on second-generation RCAs (RCA2), especially fine fractions. This study examined the properties of recycled concrete aggregates (RCAs) across first and second recycling cycles, focusing on their upcycling potential. Therefore, commercially sourced NAs and RCA1 were compared with lab-produced RCA2, both coarse and fine, derived from further recycling of first-generation recycled aggregate concrete (RAC1). Comprehensive tests assessed morphology and physical, mechanical, and microstructural properties to provide a clear insight into how RCA2 differs from RCA1. Average sphericity for coarse RCA1 was 0.81, an 8% decrease from NA’s 0.88, while RCA2 had an average sphericity of 0.76, a 14% decrease. The results revealed a progressive decline in aggregate quality with each cycle. RCA1 exhibited water absorption of 9.53% (fine) and 5.55% (coarse), while RCA2 showed higher absorption at 13.16% (fine) and 6.88% (coarse). RCA1’s crushing value was 25.9%, a 41% rise over NA’s 18.09%, while RCA2’s reached 29.2%, a 61% increase. Coarse RCA2 contained 51.03% attached old mortar, 50% more than the 33.95% in RCA1. Fine RCA2 showed significant performance reductions, limiting these aggregates to non-structural downcycling applications. Microstructure analyses confirmed RCA2’s porous structure, attributed to increased adhered old mortar, including multiple weak interfaces, and numerous microcracks compared to RCA1, necessitating careful consideration when using coarse RCA2 for upcycling in sustainable construction. Full article

This study examined the diffusion of nutrients (NH₄⁺, NO₃⁻, and PO₄³⁻) in the pore water of intertidal sediments in Lake Komuke (located in the northeastern part of Hokkaido on the coast of Okhotsk Sea) across nine stations, at 0 cm to 40 cm depths, from 19 May to 23 August 2015. A comparison was made between the traditional version of Fick’s first law and a modified version to understand nutrient diffusion in the intertidal flat. The novelty of this study lies in establishing a flux correction factor as a function of the activity coefficient in intertidal sediments. The outcomes of the standard and modified versions of Fick’s law exhibited observable physical differences between stations for all nutrients. However, the statistical analysis demonstrated significant differences only for NO₃⁻ and PO₄³⁻ at stations D, E, and F, suggesting that there is no statistically meaningful difference in NH₄⁺ flux. A statistical comparison of 27 pairs of fluxes obtained by the classical and modified versions of Fick’s first law indicated that 88.9% of the differences were not statistically significant between the two methods, and 11.1% were statistically significant. This shows the consistency of the modified method, firstly in reproducing the classical version of Fick’s law, and secondly in improving upon it, in a porous medium. These findings indicate that the modified version of Fick’s first law is an accurate methodology for evaluating nutrient diffusion dynamics in intertidal environments, and is potentially applicable to coastal salt marshes, with practical implications for environmental management and conservation efforts. Full article

Non-precious catalysts for alkaline hydrogen evolution reaction (HER) face a fundamental multi-scale challenge: lack of synergy between electronic structure tuning for balancing H adsorption and water dissociation, active site stabilization for boosting intrinsic turnover frequency (TOF), and mass transport. Even Pt loses 2–3 orders of magnitude activity in alkaline media due to inefficient water dissociation, a synergistic gap unresolved by the Sabatier principle alone. Existing strategies only address isolated aspects: phase engineering optimizes electronic structure but not active site stability; heteroatom doping introduces defects unlinked to mass transport; and nanostructuring enhances mass transfer but not atomic-level activity. None of them address multi-scale mechanistic synergy. Herein, we design a hierarchically porous P-doped NiCo alloy (hpP-NiCo) with an aim of achieving this synergy via integrating α-FCC/ε-HCP phases, P-induced defects, and 3D porosity. The formed α/ε interface tunes the d-band center to balance H adsorption and water dissociation; and the doped P stabilizes metal-vacancy sites to boost TOF. In addition, porosity matches mass transport with active site accessibility. In 1 M KOH, hpP-NiCo reaches 1000 mA cm⁻² at 185 mV overpotential and has a Tafel slope of 43.1 mV dec⁻¹, corresponding to electrochemical desorption as the rate-limiting step and verifying Volmer acceleration. Moreover, it also exhibits bifunctional oxygen evolution reaction (OER), achieving 100 mA cm⁻² at potential of 1.55 V. This work establishes a mechanistic synergy model for non-precious HER catalysts. Full article

A six-year-old, neutered male Pomeranian weighing 4.25 kg was presented with a two-year history of non-weight-bearing lameness of the left thoracic limb following an untreated traumatic olecranon fracture. Orthopedic examination revealed markedly reduced elbow joint range of motion and muscle atrophy. Radiographs demonstrated a distinct fracture line with proximolateral displacement of the olecranon fragment. Preoperative computed tomography (CT) and three-dimensional (3D) reconstruction were used to establish the surgical plan and to pre-contour a locking plate. Surgical treatment was performed in sequential steps, including removal of scar tissue, reopening of the bone marrow channel, and internal fixation. Considering the compromised biological environment of a chronic non-union, a bioactive graft composed of porous leaf-stacked structure (LSS) polycaprolactone particles incorporating recombinant human bone morphogenetic protein-2 (rhBMP-2) and mesenchymal stem cells (MSCs) was applied in combination with plate-screw fixation. The patient showed progressive improvement after surgery, achieving full weight-bearing and restoration of elbow joint motion comparable to the contralateral side. Follow-up radiographs and CT confirmed fracture union, and the radiolucency of the LSS scaffold enabled precise monitoring of bone healing. This case highlights the potential utility of combining patient-specific surgical planning with sustained delivery of rhBMP-2 and MSCs using LSS particles for the management of chronic non-union fractures in small animals. Full article

Polymer-based aerogels have recently received considerable research attention as a favorable option for oil–water separation due to their enhanced porous 3D structure with great specific surface area, low density and outstanding sorption behavior. Additionally, polymer-containing aerogels exhibit more favorable characteristic properties, such as being lipophilic–hydrophobic (superhydrophobic–superoleophilic), hydrophilic–lipophobic (superhydrophilic–underwater oleophobic), or other specific wetness forms, including anisotropic and dual-wettability. In this review, cellulose and cellulose-based materials used as an aerogel for oil–water separation are comprehensively reviewed. This review highlights the significance of cellulose and cellulose-based combinations through structure–property interactions, surface modifications (using different hydrophilic and hydrophobic agents), and aerogel formation, focusing on the light density and high surface area of aerogels for effective oil–water separation. This article provides an in-depth review of four primary classifications of cellulose-based aerogels, namely, cellulose aerogels (regenerated cellulose and bacterial cellulose), cellulose with biopolymer-based aerogels (chitosan, lignin, and alginate), cellulose with synthetic polymer aerogels (polyvinyl alcohol, polyetherimide, polydopamine and others), and cellulose with organic/inorganic (such as SiO₂, MTMS, and tannic acid) material-based aerogels. Furthermore, the aspects of performance, scalability, and durability have been explained, alongside potential prospect directions for the advancement of cellulose aerogels aimed at their widespread application. This review article stands apart from previously published review works and represents the comprehensive review on cellulose-based aerogels for oil–water separation, featuring wide-ranging classifications. Full article

The objective of this study was to investigate the adsorption of 11 azoles (tebuconazole, ketoconazole, econazole, miconazole, fluconazole, clotrimazole, climbazole, flutriafol, epoxiconazole, tiabendazole, and imazalil) on natural and waste-derived sorbents such as ceramsite, perlite, pumice, sawdust, coconut fibers, heavy oil fly ash (HOFA), activated carbon, and silica gel. The results of adsorption efficiency for most sorbents varied depending on the azole compounds and their concentration. The highest adsorption for all tested compounds was obtained for activated carbon and heavy oil fly ash, reaching about 100% in both tested concentrations (0.2 mg L⁻¹ and 0.02 mg L⁻¹). The HOFA material was characterized in terms of elemental analysis (CHNS), confirming the elemental contents of 52% C, 0.65% H, 0.4% N, and 2.3% S. The specific surface area of HOFA was 11.2 m² g⁻¹, and scanning electron microscopy (SEM) results showed the spherical yet porous nature of the particles. Furthermore, the calculated adsorption isotherms demonstrated that for most tested azoles, the Dubinin–Radushkevich (D-R) isotherm best fits the data, with R² = 0.93 or more, which is characteristic of porous carbon materials. The results highlight the significant potential of the tested HOFA sorbent for effectively removing azoles, as the tests performed showed that it was possible to remove these compounds with a concentration of up to 0.2 mg L⁻¹ within an hour. This is particularly important because HOFA is an easily accessible waste material. Furthermore, the adsorption of azoles will not increase the cost of HOFA disposal when using the standard procedures currently applied to this waste. Full article

The increasing demand for reliable, sensitive, and cost-effective gas sensors drives ongoing research in this field. Ideal gas sensors must demonstrate high sensitivity and selectivity, stability, rapid response and recovery times, energy efficiency, and affordability. One-dimensional (1D) metal oxide semiconductors (MOSs) are prominent candidates due to their excellent sensing properties and straightforward fabrication processes. The sensing efficacy of 1D MOSs is heavily dependent on their surface area and porosity, which influence gas interaction and detection efficiency. Polymeric templates serve as effective tools for enhancing these properties by enabling the creation of uniform, porous nanostructures with high surface area, thereby improving gas adsorption, sensitivity, and dynamic response characteristics. This review systematically examines the role of polymeric templates in the construction of 1D MOSs for gas sensing applications. It discusses critical factors influencing polymer template selection and how this choice affects key microstructural parameters, such as grain size, pore distribution, and defect density, essential to sensor performance. The recent literature highlights the mechanisms through which polymer templates facilitate the fine-tuning of nanostructures. Future research directions include exploring novel polymer architectures, developing scalable synthesis methods, and integrating these sensors with emerging technologies. Full article

Iodine deficiency remains a significant nutritional problem, which stimulates the search for sustainable approaches to biofortification of vegetable crops. The aim of the work was to develop a “smart” bio-iodine fertilizer based on the organoiodide complex 1-carboxy-2-phenylethan-1-aminium iodide 2-azaniumyl-3-phenylpropanoate (PPI) and highly porous biochar from agro-waste, assessing its efficiency on the parsley model. PPI was synthesized and characterized (IR/UV spectroscopy, thermal analysis), and biochar was obtained by KOH activation and studied by low-temperature nitrogen adsorption (S_BET) methods, as well as standard physico-chemical characterization. The granulated composition PPI + biochar (BIOF) was tested in pot experiments in comparison with KI and control. The biomass of leaves and roots, iodine and organic nitrogen content, and antioxidant indices (ascorbic acid, total polyphenols, antioxidant activity) were assessed. BIOF provided a significant increase in yield and nutrition: leaf mass reached 86.55 g/plant versus 77.72 g/plant with KI and 65.04 g/plant in the control; root mass—up to 8.25 g/plant (p < 0.05). Iodine content in leaves and roots increased to 11.86 and 13.23 mg/kg (d.w.), respectively, while organic nitrogen levels increased simultaneously (57.37 and 36.63 mg/kg). A significant increase in the antioxidant status was noted (ascorbic acid 36.46 mg/100 g dry weight; antioxidant activity 44.48 mg GA/g; polyphenols 23.79 mg GA/g). The presented data show that the combination of PPI with activated biochar forms an effective platform for controlled supply of iodine to plants, increasing the yield and functional qualities of products; the prospects for implementation are associated with field trials and dosage optimization. Full article

Understanding the fluid storage and production mechanisms in sedimentary rocks is vital for optimising natural gas extraction and subsurface resource management. This study applies high-resolution X-ray computed tomography (≈15 μm) to digitise rock samples from onshore Cyprus, producing digital rock models from DICOM images. The workflow, including digitisation, numerical simulation of natural gas flow, and experimental validation, demonstrates strong agreement between digital and laboratory-measured porosity, confirming the methods’ reliability. Synthetic sand packs generated via particle-based modelling provide further insight into the gas storage mechanisms. A linear porosity–permeability relationship was observed, with porosity increasing from 0 to 35% and permeability from 0 to 3.34 mD. Permeability proved critical for production, as a rise from 1.5 to 3 mD nearly doubled the gas flow rate (14 to 30 fm³/s). Grain morphology also influenced gas storage. Increasing roundness enhanced porosity from 0.30 to 0.41, boosting stored gas volume by 47.6% to 42 fm³. Although based on Cyprus retrieved samples, the methodology is applicable to sedimentary formations elsewhere. The findings have implications for enhanced oil recovery, CO₂ sequestration, hydrogen storage, and groundwater extraction. This work highlights digital rock physics as a scalable technology for investigating transport behaviour in porous media and improving characterisation of complex sedimentary reservoirs. Full article

In Liquid Composite Molding (LCM), the high variability present in reinforcement properties such as permeability creates additional challenges during the injection process, such as void formation. Although improved injection strategy designs can mitigate the formation of defects, these processes can benefit from real-time process monitoring and control to adapt the injection conditions when needed. In this study, a machine vision algorithm is proposed, with the objective of detecting and tracking both fluid flow and bubbles in an LCM setup. In this preliminary design, 3D-printed porous geometries are used to mimic the architecture of textile reinforcements. The results confirm the applicability of the proposed approach, as the detection and tracking of the objects of interest is possible, without the need to incur in elaborate experimental preparations, such as coloring the fluid to increase contrast, or complex lighting conditions. Additionally, the proposed approach allowed for the formulation of a new dimensionless number to characterize bubble transport efficiency, offering a quantitative metric for evaluating void transport dynamics. This research underscores the potential of data-driven approaches in addressing manufacturing challenges in LCM by reducing the overall process monitoring complexity, as well as using the acquired reliable data to develop robust, data-driven models that offer new understanding of process dynamics and contribute to improving manufacturing efficiency. Full article

We present the rational design of nanosized Pt nanocrystals immobilized on biomass-derived porous carbon matrices (Pt/BPC) through a convenient and eco-friendly strategy using wheat flour as a sustainable precursor. Interestingly, the three-dimensional BPC conductive network with optimized pore geometry enables enhanced metal–support interaction through d-orbital electron coupling, while the nitrogen-rich carbon scaffold provides abundant nucleation sites for the growth of ultrasmall Pt and effectively prevents them from aggregation. Accordingly, the resultant Pt/BPC catalyst demonstrates exceptional methanol oxidation performance with a large electrochemical surface area, a high mass activity of 1232.5 mA mg⁻¹, and excellent long-term stability, representing significant improvements over conventional carbon (e.g., carbon black, carbon nanotube, graphene, etc.)-supported Pt catalysts. Full article

Finding eco-friendly alternatives to the synthetic materials used for acoustic application in building industry is necessary to address environmental sustainability. Biocomposites of natural fibers combined with a biopolymer matrix emerge as a promising approach. In this study, soy protein biocomposites were prepared with 10, 15, and 20 wt% sheep wool and were added spent coffee grounds by freeze-drying to create fibro-porous biocomposites for acoustic applications. Transmission loss (TL) measurements underlined good behavior as sound insulators, with maximum values around 22 dB at 2500 Hz and even better performance than those of commercial synthetic solutions. The obtained sound absorption coefficients were competitive, as they almost reached unity at medium and high frequencies. Airflow resistivity was determined, and values were higher for the biocomposites with coffee grounds, specifically 14–18 kPa·s·m⁻² vs. 5.62–11.6 kPa·s·m⁻². Using the input of the measured airflow resistivity, an empirical model using a genetic algorithm was developed as a prediction tool for the sound absorption performance of the samples. All in all, results showcase the feasibility of employing the studied biocomposites as competitive sound insulators and absorbers in building construction industry. Full article

Titanium dioxide (TiO₂), owing to its excellent photocatalytic performance and environmental friendliness, holds great potential in the remediation of water pollution. In this study, we introduce a green and facile strategy to fabricate TiO₂-based hybrid aerogels, in which the peptide FQFQFIFK first self-assembles into peptide nanofibers (PNFs), followed by in situ biomineralization of TiO₂ on the PNFs. The TiO₂-loaded PNFs are then combined with graphene oxide (GO) via π–π interactions and integrated with microcrystalline cellulose (MCC) to construct a stable three-dimensional (3D) porous framework. The resulting GO/MCC/PNFs-TiO₂ aerogels exhibit high porosity, low density, and good mechanical stability. Photocatalytic experiments show that the aerogels efficiently degrade various organic dyes (methylene blue, rhodamine B, crystal violet, and Orange II) and antibiotics (e.g., tetracycline) under visible-light irradiation, achieving final degradation efficiencies higher than 90%. The excellent performance is attributed to the synergistic effect of the ordered interface provided by the PNF template, the stabilization and uniform dispersion facilitated by GO, and the mechanically robust 3D scaffold constructed by MCC. This work provides an efficient and sustainable strategy for designing functional hybrid aerogels and lays a foundation for their application in water treatment and environmental remediation. Full article