Search Results (78)

This study investigates the influence of land use and land cover (LULC) on the distribution of extreme rainfall in the tropical coastal city of Natal, Brazil. Hourly precipitation data from eight automatic rain gauges (2014–2023) were quality-controlled, with only days containing 24 h continuous records retained. Rainfall events were classified into light (<5 mm), normal (5–10 mm), intense (40–50 mm), and extreme (>50 mm) categories, and for each category daily accumulation, duration, intensity, and maximum hourly peaks were calculated. Seasonal and spatial differences across administrative zones were assessed using multivariate analysis of variance (MANOVA). The LULC changes were evaluated from the MapBiomas Collection 9 dataset. Results show that between 1985 and 2020, the proportion of urbanized (non-vegetated) surfaces increased from 27.7% (42.3 km²) to 64.3% (99.7 km²), mainly in the North and West zones, replacing agricultural and vegetated areas. The East and North zones, the most urbanized areas, recorded higher daily averages of extreme rainfall in the dry season (85–88 mm) than in the wet season (78–82 mm), with maximum peaks up to 26 mm/h and durations exceeding 17 h. These findings demonstrate that rapid urban expansion intensifies rainfall extremes, underscoring the importance of incorporating LULC monitoring (e.g., MapBiomas) and spatial planning into climate adaptation strategies for medium-sized cities. Full article

As a typical representative of soft capping, primary vegetation capping has both protective and destructive effects on earthen city walls. Addressing its detrimental aspects constitutes the central challenge of this project. Because the integration of MICP technology with plants offered advantages, including soil solidification, erosion resistance, and resilience to dry–wet cycles and freeze–thaw cycles, the application of MICP technology to root–soil composites was proposed as a potential solution. Employing a combined approach of RF-RFE-CV modeling and microscopic imaging on laboratory samples from the Western City Wall of the Jinyang Ancient City in Taiyuan, Shanxi Province, China, key factors and characteristics in the mineralization process of Sporosarcina pasteurii were quantified and observed systematically to define the optimal pathway for enhancing urease activity and calcite yield. The conclusions were as follows. The urease activity of Sporosarcina pasteurii was primarily regulated by three key parameters with bacterial concentration, pH value, and the intensity of urease activity, which required stage-specific dynamic control throughout the growth cycle. Bacterial concentration consistently emerged as a high-importance feature across multiple time points, with peak effectiveness observed at 24 h (1.127). pH value remained a highly influential parameter across several time points, exhibiting maximum impact at around 8 h (1.566). With the intensity of urease activity, pH exerted a pronounced influence during the early cultivation stage, whereas inoculation volume gained increasing importance after 12 h. To achieve maximum urease activity, the use of CASO AGAR Medium 220 and the following optimized culture conditions was recommended: an activation culture time of 27 h, an inoculation age of 16 h, an inoculation volume of 1%, a culture temperature of 32 °C, an initial pH of 8, and an oscillation speed of 170 r/min. Furthermore, to maximize the yield of CaCO₃ in output and the yield of calcite in CaCO₃, the following conditions and procedures were recommended: a ratio of urea concentration to Ca²⁺ concentration of 1 M:1.3 M, using the premix method of Sporosarcina pasteurii, quiescent reaction, undisturbed filtration, and drying at room-temperature in the shade environment. Full article

In this paper, we investigate the thread oscillations in a quiescent prominence observed by New Vacuum Solar Telescope at the H$\alpha$ line center on 17 April 2024. Each individual thread is traced by the local maximum intensity on the time–distance maps. Although there are numerous threads in this prominence, 24 oscillating threads are identified at eight slits parallel to the solar surface. A sinusoidal function is used to fit them, and about 1.5 cycles of oscillations and a mean period of 27.7 min are detected. We find that all these 24 threads display the oscillation with almost a constant amplitude with an average value of about 0.92 Mm, with no damping or expansion during their lifetimes. Furthermore, we find the oscillations at different positions on a same thread almost have a similar period of 88.7 min in phase, which indicates that the thread oscillations could be triggered by a standing-type wave. Using the typical parameters in the prominence, the magnetic field strength (B) is estimated in the range of 4 G ≤ B ≤ 21 G, which is consistent with the previous results. Our findings would provide the clues for the thread oscillation mechanism in the prominence. Full article

Resistance exercise (RE) is a well-known modality to increase skeletal muscle strength and hypertrophy. While both high-load (HL) and low-load (LL) RE stimulate skeletal muscle growth, the effects of RE load on androgen-regulated genes remain unclear. Further, the relationship between circulating and intramuscular androgen-associated targets and muscular strength and mass has not been well defined. Purpose: This investigation therein aimed to examine acute gene and hormone responses to volume- and intensity-equated RE at different loads, examining their relationships with lean body mass (LBM), strength, and circulating and intramuscular androgen-related biomarkers. Methods: Ten resistance-trained males completed one-repetition maximum (1RM) testing, as well as body composition testing, before two volume- and intensity-equated RE sessions, separated by a 7–10 day crossover period. Serum and skeletal muscle samples were collected at baseline, 3 h, and 24 h post-exercise to assess testosterone (TST), dihydrotestosterone (DHT), AR protein, AR mRNA, and AR–DNA binding. Pearson correlations evaluated any potential associations between LBM, strength, and androgen/AR biomarkers. Results: Training load did not significantly impact gene expression, but time effects were observed, whereby MyoD peaked 3 h post-exercise (2.03 ± 1.64 fold; p = 0.005), while AR mRNA decreased at 24 h (0.54 ± 0.42 fold; p = 0.021) versus baseline. LBM also correlated with bench press (r = 0.607, p = 0.048) and leg press (r = 0.705, p = 0.015) 1RM. Serum total TST correlated with leg press 1RM (r = 0.909, p = 0.012), while serum-free TST correlated with AR mRNA fold-change (r = 0.392, p = 0.001) and AR–DNA binding (r = 0.287, p = 0.021). Intramuscular DHT correlated with intramuscular TST (r = 0.415, p < 0.001) and AR protein (r = 0.421, p < 0.001). Lastly, fold changes in AR mRNA were correlated with MyoD mRNA fold changes (r = 0.785, p = 0.007) along with IGF1-Ea mRNA fold changes being significantly correlated with both myogenin mRNA fold changes (r = 0.865, p = 0.001) and AR-DNA binding (r = −0.727, p = 0.017). Conclusions: Despite no observable load-specific effects, RE elicited time-dependent increases in MyoD and AR mRNA expression. This reinforces prior LBM and maximal muscular strength relationship evidence whilst also lending new insights into circulating and intramuscular androgen interactions with AR. Full article

The expected population rise will require a maximum exploitation of agricultural lands with a consequent increase in the demand for freshwater for irrigation uses. Future trends predict increasing periods of drought stress, which may impact on crop performance and limit the future production. Pepper is one of the most economically important crops and globally consumed vegetables. This crop is highly demanding in terms of water supply, and so far, developing tolerant cultivars is one of the main targets for breeding. The aim of this study is to accurately determine how pepper plants react to water stress at the vegetative stage in order to select genotypes that better cope with drought. We implemented the PhenoHort Plant Eye phenotyping platform to precisely assess changes in plant architecture and morpho-physiological parameters on 25 cultivated pepper genotypes (Capsicum annuum) under drought stress conditions. Three different irrigation supply levels were considered, including the control, intense, and severe water stress, by irrigating every 24, 72, and 96 h, respectively. Daily monitoring of 20 traits allowed ~190,000 multispectral and tridimensional data points through scans over 6 weeks of cultivation, thus shedding light on changes in plant architecture and vegetation indices’ values during stress. The dissection of genotype (G) and treatment (T) interactions revealed that digital biomass and plant height traits were strongly affected by the T factor (more than 50% of total variance), whereas color and multispectral parameters were under greater genotypic control, accounting for 58.27% and 64.97% of the total variance for HUE and NPCI, respectively. The comparison of each accession with respect to the control and the application of multivariate models allowed us to select four drought-tolerant lines (G1, G2, G22, and G25) able to reduce the effects of drought on the morphological parameters and architecture of the plant with positive effects on vegetative indices. This work represents the first attempt to dissect the response of pepper under drought stress at the vegetative stage using a high-throughput and non-invasive phenotyping system, offering new insights for selecting resilient genotypes. Full article

Background/Objectives: High-intensity interval training (HIIT) is considered an effective way in improving aerobic capacity and selected health parameters. Ashwagandha is an herb with possible health-promoting properties that may affect metabolism and performance. The aim of this study was to evaluate the effects of ashwagandha supplementation (600 mg/day) during an 8-week HIIT on body composition, lipid profile and hormone levels related to energy homeostasis in healthy young men. Methods: The study was randomised, double-blind and placebo-controlled (Placebo group, PL, n = 20; ashwagandha, A, n = 18). HIIT was conducted on a rowing ergometer (3 times per week, 5–7 series of 1.5 min at 85–95% of maximum power, with intervals of 1.5 min at 70 W). Body composition (BIA, Tanita TBF 300P), serum lipid profile (tChol, HDL-cholesterol, LDL-cholesterol, TG) and serum levels of adiponectin, asprosin and irisin were analysed before (term 1) and after the8-week study (term 2). Both the lipid and hormonal profiles were measured in three time points: pre- and post-graded exercise test and after 24 h recovery period. Results: Analysis showed no effect of training or supplementation on body composition and lipid profile (p > 0.05). In turn, the 8-week HIIT decreased resting levels of adiponectin and increased irisin levels post-exercise and after 24 h (p < 0.05). Conclusions: In young, healthy men, an 8-week HIIT programme significantly affects selected hormones related to energy metabolism of adipose (adiponectin) and muscle (irisin) tissues, but ashwagandha supplementation did not significantly affect any of the hormonal parameters analysed. Full article

Flash floods arise from the interaction of rugged topography, short-duration intense rainfall, and rapid flow concentration. Conventional risk mapping often builds empirical indices with expert-assigned weights or trains supervised models on historical event inventories—approaches that degrade in data-scarce regions. We propose a fully data-driven, unsupervised Geographic Information System (GIS) framework based on fractional order k-means, which clusters multi-dimensional geospatial features without labeled flood records. Five raster layers—elevation, slope, aspect, 24 h maximum rainfall, and distance to the nearest stream—are normalized into a feature vector for each 30 m × 30 m grid cell. In a province-scale case study of Zhejiang, China, the resulting risk map aligns strongly with the observations: 95% of 1643 documented flash flood sites over the past 60 years fall within the combined high- and medium-risk zones, and 65% lie inside the high-risk class. These outcomes indicate that the fractional order distance metric captures physically realistic hazard gradients while remaining label-free. Because the workflow uses commonly available GIS inputs and open-source tooling, it is computationally efficient, reproducible, and readily transferable to other mountainous, data-poor settings. Beyond reducing subjective weighting inherent in index methods and the data demands of supervised learning, the framework offers a pragmatic baseline for regional planning and early-stage screening. Full article

The increasing frequency and intensity of extreme weather events pose significant challenges to mountain communities, particularly in terms of flash flood risks. This study presents a framework for stress testing and evaluating flood resilience in mountain communities through the integration of high-resolution InfoWorks ICM two-dimensional hydrodynamic modeling and systematic resilience assessment. The framework makes three key innovations: (1) multi-scale temporal stress scenarios combining short-duration extreme events (1–2 h) with long-duration persistent events (24 h) and historical extremes; (2) integrated infrastructure–drainage stress analysis that explicitly models roads’ dual role as critical infrastructure and emergency drainage channels; and (3) dynamic resilience quantification under multiple stressors across 15 systematically designed stress conditions. Using Western Beijing as a case study, the model is validated, achieving Nash–Sutcliffe efficiency values exceeding 0.9, demonstrating its robust capability in simulating complex mountainous terrain flood processes. Through systematic analysis of fifteen rainfall scenarios designed based on Chicago rainfall patterns and historical events (including the July 2023 Haihe River basin flood), encompassing various intensities (30–200 mm/h), durations (1 h, 2 h, 24 h), and return periods (10, 50, 100 years), the key findings include the following: (1) A rainfall intensity of 60 mm/h represents a crucial threshold for system performance, beyond which significant impacts on community infrastructure emerge, with built-up areas experiencing inundation depths of 0.27–0.4 m that exceed safe passage limits. (2) Road networks become primary drainage channels during intense precipitation, with velocities exceeding 5 m/s in village roads and exceeding 5 m/s in country road sections, creating significant hazard potential. (3) Four major risk spots were identified with distinct waterlogging patterns, characterized by maximum depths ranging from 0.8 to 2.0 m and recovery periods varying from 2 to 12 hours depending on the topographic confluence effects and drainage efficiency. (4) The system demonstrates strong recovery capability, achieving >90% recovery within 3–6 hours for short-duration events, while showing vulnerability to extreme scenarios, with performance declining to 0.75–0.80, highlighting the coupling effects between water depth and flow velocity in steep terrain. This research provides quantitative insights for flood risk management and for enhancing community resilience in mountainous regions, offering valuable guidance for infrastructure improvement, emergency response optimization, and sustainable community development. This study primarily focuses on physical resilience aspects, with socioeconomic and institutional dimensions representing important directions for future research. Full article

Apiculture is among the most weather-dependent sectors of agriculture; however, quantifying the impact of meteorological factors remains challenging. Beehive weight has long been recognized as an important indicator of colony health, strength, and food availability, as well as foraging activity. Atmospheric influences on hive weight dynamics have been a subject of research since the early 20th century. This study aims to estimate hourly hive weight variation by applying linear time-series models to hive weight data collected from active apiaries during intensive foraging periods, considering atmospheric predictors. We employed a rolling 24 h forward ARIMAX and SARIMAX model, incorporating meteorological variables as exogenous factors. The median estimates for the study period resulted in model RMSE values of 0.1 and 0.3 kg/h. From numerous meteorological variables, the hourly maximum temperature was found to be the most significant predictor. ARIMAX model results also exhibited a strong diurnal cycle, pointing out the weather-driven seasonality of hive weight variations. Full article

Background/Objectives: Beetroot juice (BJ), a natural source of dietary nitrate, has gained increasing attention for its potential to improve exercise performance and cardiovascular function. While its benefits are well documented in endurance contexts, less is known about its short-term effects on resistance training performance and recovery. Thus, this study investigated the effects of short-term BJ supplementation on strength performance, cardiovascular responses, muscle oxygenation, and post-exercise recovery in resistance-trained males. Methods: Twelve healthy men (age: 21.3 ± 1.9 years; body mass index: 21.42 ± 2.36 kg/m²) completed two supplementation protocols involving BJ, providing 450 mg of nitrate per day, and a nitrate-free placebo (PLA). Each protocol consisted of two laboratory visits, one to assess the acute ergogenic effects and another to evaluate recovery after 72 h, resulting in a total of four sessions over a two-week period. During the three consecutive days of supplementation, participants ingested a single 900 mL dose (15 g BJ powder/PLA) 2 h before the first session, followed by three daily 300 mL doses (5 g BJ each/PLA) over the next two days, and a final dose (15 g BJ powder/PLA) taken 2 h before the second session (72 h post-first session). Each testing session involved incremental back squat (BS) and bench press (BP) exercises at 60%, 70%, and 80% of the one-repetition maximum (1RM) performed to failure, with three-minute rest intervals between sets. Repetition to failure, movement velocity, peak power, peak heart rate (HR), and muscle oxygenation (SmO₂) were recorded during BP and BS exercises. Heart rate variability (HRV) and blood lactate were assessed before and after each training session. Lower-limb strength (CMJ and SJ) and delayed-onset muscle soreness (DOMS) were assessed daily during the 3-day supplementation period. Results: BJ significantly increased repetitions completed at 80% 1RM during BP and BS (p < 0.05) compared to the PLA. Peak movement velocity improved across all intensities using BJ with higher values compared to the PLA at 60–80% 1RM (p < 0.05). SmO₂ was higher in BJ at 70–80% 1RM) and further improved after 72 h of BJ supplementation (p < 0.05). Cardiovascular strain was reduced in BJ, evidenced by lower peak HRs and smaller post-exercise declines in HRV indices (p < 0.05). Post-exercise recovery favored BJ, with faster recovery in jump performance at 24 h and reduced upper-limb DOMS at 24–48 h (p < 0.05). Conclusions: Short-term BJ supplementation enhances high-intensity resistance performance, improves muscle oxygenation, attenuates cardiovascular strain, and accelerates neuromuscular recovery. These benefits highlight its potential as a practical strategy for athletes seeking to optimize training performance and recovery during periods of intense resistance training. Full article

Worldwide, the yellow-fleshed kiwifruit (Actinidia chinensis) is an important crop that possesses great economic significance due to its nutritional, medicinal and ornamental values. The call for the expansion of the kiwifruit industry in South Africa, due to rising local and international market demand, resulted in the introduction of new plant species in sub-mountainous areas, where soil and climate conditions are more suitable for intensive kiwifruit production than in lowland areas. Consequently, a need to develop suitable commercial protocols for mass propagation of A. chinensis emerged. This study introduces an optimized micropropagation protocol for A. chinensis, facilitating seed germination, seedling development and multiple shoot induction. For seed germination, the effect of cold stratification (CS) and gibberellic acid (GA₃) alone and in combination on in vitro germination of A. chinensis seeds was studied. Sterile seeds were stratified at 4 °C for 28 and 42 days. Batches of stratified and non-stratified (control) seeds were germinated on plant growth regulator-free Murashige and Skoog (MS) media and also on sterile filter paper bridges moistened with dH₂O and GA₃ concentrations of 500, 1000, 1500, 2000 and 2500 ppm. Seeds from the control and the CS treatments alone did not germinate on MS medium. However, on filter paper bridges, seeds cold stratified for 28 days yielded only a 20% germination percentage (GP), whereas CS for 42 days did not promote germination. A maximum GP of 64% and a mean germination time (MGT) of 27.52 days were achieved at a 2000 ppm GA₃ concentration. Cold stratification (28 days) followed by GA₃ treatments yielded an optimum GP of 80% and optimum MGT of 18.94 days at GA₃ concentrations of 500 ppm. In contrast, CS (42 days) followed by GA₃ yielded a maximum GP of 72% and MGT of 18.80 days at a GA₃ of 500 ppm. Conclusively, CS alone had little effect on germination, whereas CS (28 and 42 days) followed by GA₃ significantly (p ≤ 0.05) improved GP. Germinated seeds on moist filter paper can produce seedlings when sub-cultured on MS medium for seedling development. For multiple shoot induction, in vitro shoot culture of A. chinensis was carried out using apical and basal shoot explants from the above in vitro-produced seedlings. These explants were cultured on MS supplemented with 2.2 µM and 4.4 µM 6-Benzylaminopurine (BAP) for shoot multiplication. Axillary shoot proliferation was not observed on apical shoot explants after 4 weeks of culture on MS medium with 2.2 µM BAP. In contrast, the basal shoot explants produced 2–3 axillary shoots, tendrils and calluses at the base on the same medium. The highest number (3–4) of multiple shoots was attained from these basal shoot explants after subculture (10–12 weeks) in the same culture medium. In contrast, only elongation and rooting of apical shoot explants, without axillary shoot induction, occurred after the subculture. Regenerated plantlets derived from both apical and basal shoot explants were successfully acclimatised under a controlled environment at 24 ± 2 °C and 16 h photoperiod of 150–200 µmol m⁻² s⁻¹ light intensity. A similar response was observed for both types of explants of A. chinensis when cultured on MS with 4.4 µM BAP, although the higher concentration of BAP affected the morphological appearance of the regenerated plantlets that had shorter stems and smaller and narrower leaves compared to plantlets derived from 2.2 µM BAP. Full article

This study investigates the grain morphology, microstructure, magnetic properties and shape memory properties of an Fe_41.265Ni_28.2Co₁₇Al₁₁Ta_2.5B_0.04 (at%) high-entropy alloy (HEA) cold-rolled to 98%. The EBSD results show that the texture intensities of the samples annealed at 1300 °C for 0.5 or 1 h are 2.45 and 2.82, respectively. This indicates that both samples were formed without any strong texture. The grain morphology results show that the grain size increased from 356.8 to 504.6 μm when the annealing time was increased from 0.5 to 1 h. The large grain size improved the recoverable strain due to a reduction in the grain constraint. As a result, annealing was carried out at 1300 °C/1 h for the remainder of the study. The hardness decreased at 24 h, then increased again at 48 h; this phenomenon was related to the austenite finish temperature. Thermo-magnetic analysis revealed that the austenite finish temperature increased when the samples were aged at 600 °C for between 12 and 24 h. When the aging time was prolonged to 48 h, the austenite finish temperature value decreased. X-ray diffraction (XRD) demonstrated that the peak of the precipitates emerged and intensified when the aging time was increased from 12 to 24 h at 600 °C. From the three-point bending shape memory test, the samples aged at 600 °C for 12 and 24 h had maximum recoverable strains of 2% and 3.6%, respectively. The stress–temperature slopes of the austenite finish temperature were 10.3 MPa/°C for 12 h and 6 MPa/°C for 24 h, respectively. Higher slope values correspond to lower recoverable strains. Full article

Extremely severe cyclonic storms over the North Indian Ocean increased by approximately 10% during the past 30 years. The climatological characteristics of tropical cyclones for 38 years were assessed over the Bay of Bengal (BoB). A total of 24 ESCSs formed over the BoB, having their genesis in the southeast BoB, and the intensity and duration of these storms have increased in recent times. The Advanced Research version of the Weather Research and Forecasting (ARW) model is utilized to simulate the five extremely severe cyclonic storms (ESCSs) over the BoB during the past two decades using the Indian Monsoon Data Assimilation and Analysis (IMDAA) data. The initial and lateral boundary conditions are derived from the IMDAA datasets with a horizontal resolution of 0.12° × 0.12°. Five ESCSs from the past two decades were considered: Sidr 2007, Phailin 2013, Hudhud 2014, Fani 2019, and Amphan 2020. The model was integrated up to 96 h using double-nested domains of 12 km and 4 km. Model performance was evaluated using the 4 km results, compared with the available observational datasets, including the best-fit data from the India Meteorological Department (IMD), the Tropical Rainfall Measuring Mission (TRMM) satellite, and the Doppler Weather Radar (DWR). The results indicated that IMDAA provided accurate forecasts for Fani, Hudhud, and Phailin regarding the track, intensity, and mean sea level pressure, aligning well with the IMD observational datasets. Statistical evaluation was performed to estimate the model skills using Mean Absolute Error (MAE), the Root Mean Square Error (RMSE), the Probability of Detection (POD), the Brier Score, and the Critical Successive Index (CSI). The calculated mean absolute maximum sustained wind speed errors ranged from 8.4 m/s to 10.6 m/s from day 1 to day 4, while mean track errors ranged from 100 km to 496 km for a day. The results highlighted the prediction of rainfall, maximum reflectivity, and the associated structure of the storms. The predicted 24 h accumulated rainfall is well captured by the model with a high POD (96% for the range of 35.6–64.4 mm/day) and a good correlation (65–97%) for the majority of storms. Similarly, the Brier Score showed a value of 0.01, indicating the high performance of the model forecast for maximum surface winds. The Critical Successive Index was 0.6, indicating the moderate model performance in the prediction of tracks. It is evident from the statistical analysis that the performance of the model is good in forecasting storm structure, intensity and rainfall. However, the IMDAA data have certain limitations in predicting the tracks due to inadequate representation of the large-scale circulations, necessitating improvement. Full article

Background/Objectives: The purpose of this study was to develop the gemcitabine-loaded drug-eluting beads (G-DEBs) for transarterial chemoembolization (TACE) in rabbit renal tumors and to evaluate their antitumor effect using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/X-ray computed tomography (¹⁸F-FDG PET/CT). Methods: DEBs were prepared by polyvinyl alcohol-based macromer crosslinked with N-acryl tyrosine and N,N′-methylenebis(acrylamide). Gemcitabine was loaded through ion change to obtain G-DEBs. Their particle size and drug release profile were characterized. VX2 tumors were implanted in the right kidney of rabbits to establish the renal tumor model. The tumor-bearing rabbits received pre-scan by ¹⁸F-FDG PET/CT, followed by targeted transarterial injection of G-DEBs under digital subtraction angiography (DSA) guidance. The rabbits received another ¹⁸F-FDG PET/CT scan 10 or 14 days after the treatment. The therapeutic effect was further validated by histopathological analysis of the dissected tumors. Results: The average particle size of the microspheres was 58.06 ± 0.50 µm, and the polydisperse index was 0.26 ± 0.002. The maximum loading rate of G-DEBs was 18.09 ± 0.35%, with almost 100% encapsulation efficiency. Within 24 h, GEM was eluted from G-DEBs rapidly and completely, and more than 20% was released in different media. DSA illustrated that G-DEBs were delivered to rabbit renal tumors. Compared with the untreated control group with increased tumor volume and intense ¹⁸F -FDG uptake, the G-DEBs group showed significant reductions in tumor volume and maximum standard uptake value (SUV_max) 10 or 14 days after the treatment. Histopathological analysis confirmed that the proliferating area of tumor cells was significantly reduced in the G-DEBs group. Conclusions: Our results demonstrated that G-DEBs are effective in TACE treatment of rabbit VX2 renal tumors, and ¹⁸F-FDG PET/CT provides a non-invasive imaging modality to monitor the antitumor effects of TACE in renal tumors. Full article

Background: The clinical course of patients with aneurysmal SAH (aSAH) is often dynamic and highly unpredictable. Since its management varies between hospitals despite guidelines, this survey aimed to assess the current state of intensive care treatment for aSAH in the German-speaking region and provide insights that could aid standardization of care for aSAH patients in the intensive care setting. Methods: From February 2023 to April 2023, medical professionals of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI), the Initiative of German Neuro-Intensive Trial Engagement (IGNITE) network and manually recorded clinics with intensive care units were invited to participate in a standardized anonymous online questionnaire including 44 questions. The questionnaire was validated in multiple steps by experts of different specialties including those from the DIVI. A descriptive data analysis was carried out. Results: A total of 135 out of 220 participants answered the survey completely. The results showed that most patients were treated in anesthesia-led intensive care units at university and maximum care hospitals. Aneurysms were usually treated within 24 h after bleeding. If vasospasm was detected, induced hypertension was usually implemented as the first treatment option. In refractory vasospasm, interventional spasmolysis with calcium antagonists was usually carried out (81%), despite unclear evidence. There were significant discrepancies in blood pressure target values, particularly after aneurysm repair or after delayed cerebral ischemia (DCI), as well as in hemoglobin limit values for erythrocyte substitution. Despite the limited level of evidence, most institutions used temperature management (68%), including hypothermia (56%), for severe cases. Conclusions: While we anticipated variations between individual intensive care facilities, our survey identified numerous similarities in the treatment of aSAH patients. Methods such as interventional spasmolysis and temperature management were used frequently despite limited evidence. Our results can serve as a fundamental framework for formulating recommendations for intensive care treatment and planning of multicenter studies. Full article