Search Results (123)

Background and Objectives: Neonatal respiratory distress syndrome (NRDS), resulting from a deficiency of pulmonary surfactant (PS), can cause alveoli to collapse. Glucocorticoids reduce inflammation and are effective in reducing pulmonary swelling. This study aims to assess the effectiveness of the combination of PS and budesonide in the management of NRDS. Materials and Methods: Publications between 21 May and 24 November were screened through PubMed, Cochrane and Embase. Data analysis was performed on RevMan 5.3 software. Subgroup analysis was performed to evaluate the routes of administrations. Results: The use of budesonide along with pulmonary surfactant for treating NRDS revealed the following results: (1) a reduced duration of invasive mechanical ventilation (standardized mean difference (SMD) = −1.06, 95% confidence interval (CI) = −1.55 to −0.56, p < 0.0001); (2) reduced rate of bronchopulmonary dysplasia (BPD) occurrence (relative risk (RR) = 0.72, 95% CI = 0.60 to 0.86, p = 0.0003); (3) reduced duration for hospital admittance (SMD = −0.38, 95% CI = −0.64 to −0.11, p = 0.005). The occurrence of complications, i.e., sepsis, pneumothorax, retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), rate of mortality, hyperglycemia and intraventricular hemorrhage (IVH), was not significantly different among the intervention and comparison group except for patent ductus arteriosus (PDA) and pulmonary hemorrhage, with their incidence being higher in the control group (p = 0.002 and p = 0.05, respectively). Conclusions: The combination of pulmonary surfactant and budesonide decreases the occurrence of BPD, duration of mechanical ventilation, length of hospital stay and risk of pulmonary hemorrhage and PDA. It does not increase the risk of complications and death and is clinically safe. Full article

Q fever, caused by the intracellular bacterium Coxiella burnetii, is a significant zoonotic disease for which ruminants are the main reservoir. This cross-sectional study aimed to assess the seroprevalence of C. burnetii in farm animals (sheep, goats, cattle, and camels) across Saudi Arabia. A total of 7760 serum samples were collected from 2253 sheep, 2224 goats, 1111 cattle, and 2172 camels, representing various regions of the country. The samples were screened for C. burnetii antibodies using an enzyme-linked immunosorbent assay (ELISA). The findings revealed significant regional and species-specific differences. The findings revealed notable regional and species-specific variations in seroprevalence. In goats, seropositivity was detected in 92% of the tested herds; however, only 48% of the individually tested animals were found to be positive. Similarly, camels exhibited herd-level seropositivity of 92.9% of the examined herds, with only 46.7% of the individually examined animals testing positive. For sheep, 80% of the examined sheep flocks were positive, while 30.2% of the individually tested animals were positive. Cattle showed a significantly lower seroprevalence, since only 27.6% of the screened herds were found to be positive, and only 8.2% of the individually tested animals were positive. In conclusion, the results indicate that C. burnetii infection is widespread among livestock in Saudi Arabia, with goats, camels, and sheep posing a particularly elevated risk of zoonotic transmission. The observed regional disparities and species-specific infection rates highlight the need for comprehensive surveillance and targeted control strategies to mitigate the spread of Q fever in Saudi Arabia. Full article

This paper proposes a hybrid brushless wound-rotor synchronous machine (HB-WRSM) with an outer rotor topology that can operate as a permanent magnet synchronous machine (PMSM), as well as an HB-WRSM. In the first part, the existing brushless wound-rotor synchronous machine (BL-WRSM) is modified into a hybrid model by introducing permanent magnets (PMs) in the rotor pole faces to improve the magnetic field strength and other performance variables of the machine. In the second part, a centrifugal switch is introduced, which can change the machine operation from HB-WRSM to PMSM. The proposed machine uses an inner stator, outer rotor model with 36 stator slots and 48 poles, making the stator winding a concentrated winding. The HB-WRSM is utilized for dual-speed applications such as washing machines that run at low speed (46 rpm) and high speed (1370 rpm). For high speed, to have a better efficiency and less torque ripple, the machine is switched to PMSM mode using a centrifugal switch. The results are compared with the existing BL-WRSM. A 2D model is simulated using ANSYS Electromagnetics Suite to validate the machine model and performance. Full article

In this study, the generalized $(p,q)$-derivative operator is used to define a novel class of bi-univalent functions. For this class, we define constraints on the coefficients up to $|{\ell }_5|$. The functions are analyzed using a suitable operational method, which enables us to derive new bounds for the Fekete–Szegö functional, as well as explicit estimates for important coefficients like $|{\ell }_2|$ and $|{\ell }_3|$. In addition, we establish the upper bounds of the second and third Hankel determinants, providing insights into the geometrical and analytical properties of this class of functions. Full article

Trypanosomes are parasitic protozoa that cause severe diseases in humans and animals. The most important species of Trypanosmes include Trypanosoma evansi and Trypanosoma brucei gambiense. The most well-known human diseases are sleeping sickness in Africa and Chagas disease in South America. The most identified animal diseases include Nagana in the African tsetse fly belt and Surra in South Asia, North Africa, and the Middle East. Surra is caused by Trypanosoma evansi. Diminazene resistance is an emerging threat caused by T. evansi infecting animals. The underlying mechanism of diminazene resistance is poorly understood. Trypanosoma brucei gambiense causes African sleeping sickness. The development of diminazene resistance in Trypanosoma brucei gambiense is associated with the alterations in the corresponding P2 adenosine transporter-1 (AT-1) gene. In the present study, by extrapolating the findings from Trypanosoma brucei gambiense, we analyzed genetic diversity in the P2 adenosine transporter-1 gene (AT-1) from T. evansi to explore a potential link between the presence of mutations in this locus and diminazene treatment in ruminants. We examined T. evansi-infected blood samples collected from goats, sheep, camels, buffalo, and cattle in seven known endemic regions of the Punjab province of Pakistan. Heterozygosity (H_e) indices indicated a high level of genetic diversity between seven T. evansi field isolates that had resistance-type mutations at codons 178E/S, 239Y/A/E, and 286S/H/I/D/T of the P2 adenosine transporter-1 (AT-1) locus. A low level of genetic diversity was observed in 19 T. evansi field isolates with susceptible-type mutations at codons A178, G181, D239, and N286 of the P2 adenosine transporter-1 (AT-1) locus. Our results on T. evansi warrant further functional studies to explore the relationship between diminazene resistance and the mutations in AT-1. Full article

This study investigates the intricate relationship between CSR, green innovation, and environmental performance within the context of China’s manufacturing industries. Given the pressing environmental challenges faced by this sector, understanding how CSR practices correlate with sustainable innovations is critical for stakeholders aiming to enhance environmental outcomes. This was a survey-based study using a questionnaire and the five-point Likert scale; items were adopted from previous studies. Sampling was drawn through random sampling. Utilizing a sample of 327 respondents, this research employs SPSS and Structural Equation Modeling with Partial Least Squares (SEM-PLS) as analytical tools. The findings reveal a robust positive correlation between CSR practices and green innovation, as evidenced by a path coefficient of 0.704. These data support the stakeholder theory, which posits that organizations attentive to stakeholder expectations are more inclined to adopt sustainable practices. Furthermore, this study underscores the mediating role of green innovation in the relationship between CSR and environmental performance, highlighting its importance in aligning organizational strategies with sustainability-oriented stakeholder interests. This conclusion aligns with the existing literature emphasizing CSR’s significance in improving environmental performance through innovative approaches. However, an unexpected finding emerged: there exists a weak negative relationship between green innovation and organizational agility (−0.080). This suggests that, while firms strive for sustainable innovations, they may inadvertently compromise their flexibility in responding to evolving market demands. By addressing these dynamics, this research contributes valuable insights into how CSR can effectively spur green innovation and promote sustainable practices within China’s manufacturing sector. This study fills a gap in the existing literature by elucidating the mechanisms that connect CSR with enhanced environmental performance while also recognizing the potential trade-offs associated with innovation strategies. Also, the exploration of agility, which is least investigated, can also open various doors towards sustainability and the adaptation of new changes. Future research is encouraged to further explore these relationships across different industries and delve deeper into the mechanisms linking CSR to improved environmental outcomes, ultimately guiding organizations in balancing sustainability efforts with market responsiveness. Full article

Climate change effects, including temperature extremes and water stress, cause abiotic stress in plants. These changes directly affect flowering and the flower reward system for pollinators, influencing plant–pollinator interactions and ultimately seed production in flowering plants. Here, we tested the effects of water deprivation on the behavior of various pollinator species, plant–pollinator interactions, and the seed yield of sunflower, Helianthus annuus L. (Asteraceae). Sunflower was sown during four different months (January–April) and subjected to two different water availability levels (well-watered and water-deprived). Pollinator abundance was recorded five times a day (8:00 am, 10:00 am, 12:00 pm, 2:00 pm, and 4:00 pm) from flower heads and the florets. In addition, foraging behavior was also recorded. We found that lowest abundance, visit duration, and visitation rate occurred in April-sown sunflower. The European honey bee Apis mellifera L. (Hymenoptera: Apidae) was the most abundant visitor to sunflower, the hover fly Eristalinus aeneus (Diptera: Syrphidae) exhibited the longest visit duration, while Xylocopa sp. (Hymenoptera: Apidae) exhibited the highest visitation rate. The visitation rate of bees was significantly affected by water stress, with more bee visits occurring under well-watered conditions. Additionally, plant parameters, including flower head diameter, head weight, seed number, and seed weight, were significantly lower in the water-deprived treatments in April-sown sunflower. Open flowers without the pollination exclusion cages showed a higher yield, indicating the pollination dependence of sunflower. In conclusion, the plant modifications induced by sowing months and water-deprived conditions may alter pollinator behavior and may ultimately affect sunflower yield. Full article

This review provides a comprehensive overview of recent advancements in the synthesis, properties, and applications of organic materials in the optoelectronics sector. The study emphasizes the critical role of organic materials in the development of state-of-the-art optoelectronic devices such as organic solar cells, organic thin-film transistors, and OLEDs. The review further examines the structure, operational principles, and performance metrics of organic optoelectronic devices. Organic materials have emerged as promising candidates due to their low-cost production and potential for large-area or flexible substrate applications. Additionally, this review highlights the physical mechanisms governing the optoelectronic properties of high-performance organic materials, particularly photoinduced processes relevant to charge carrier photogeneration. It discusses the unique benefits of organic materials over traditional inorganic materials, including their light weight, simple processing, and flexibility. The report delves into the challenges related to stability, scalability, and performance, while highlighting the wide range of electronic properties exhibited by organic materials, which are critical for their performances in optoelectronic devices. Furthermore, it addresses the need for further research and development in this field to achieve consistent performance across different types of devices. Full article

This paper investigates the third Hankel determinant, denoted $H_3\left(1\right)$, for functions within the subclass $\mathcal{R}{\mathcal{S}}_{\sum }^{\mathrm{*}}\left(\lambda \right)$ of bi-univalent functions associated with crescent-shaped regions ${\phi }_{⦅}\left(z\right)=z+\sqrt{1+z^2}$. The primary aim of this study is to establish upper bounds for $H_3\left(1\right)$. By analyzing functions within this specific geometric context, we derive precise constraints on the determinant, thereby enhancing our understanding of its behavior. Our results and examples provide valuable insights into the properties of bi-univalent functions in crescent-shaped domains and contribute to the broader theory of analytic functions. Full article

With the development of new technologies in recent years, researchers have made significant progress in crop breeding. Modern breeding differs from traditional breeding because of great changes in technical means and breeding concepts. Whereas traditional breeding initially focused on high yields, modern breeding focuses on breeding orientations based on different crops’ audiences or by-products. The process of modern breeding starts from the creation of material populations, which can be constructed by natural mutagenesis, chemical mutagenesis, physical mutagenesis transfer DNA (T-DNA), Tos17 (endogenous retrotransposon), etc. Then, gene function can be mined through QTL mapping, Bulked-segregant analysis (BSA), Genome-wide association studies (GWASs), RNA interference (RNAi), and gene editing. Then, at the transcriptional, post-transcriptional, and translational levels, the functions of genes are described in terms of post-translational aspects. This article mainly discusses the application of the above modern scientific and technological methods of breeding and the advantages and limitations of crop breeding and diversity. In particular, the development of gene editing technology has contributed to modern breeding research. Full article

Background: Streptococcus mutans is a leading causative agent of dental caries and exerts pathogenicity by forming biofilms. Dental caries continues to be a significant public health issue worldwide, affecting an estimated 2.5 billion people, showing a 14.6% increase over the past decade. Herein, the antibacterial potential of Chlorophyllin extracted from Spinacia oleracea was evaluated against biofilm-forming S. mutans via in vitro and in silico studies. Methodology: The antimicrobial activity of chlorophyllin extract against S. mutans isolates was tested using the agar well diffusion method. Chlorophyllin extract was also tested against biofilm-forming isolates of S. mutans. Chlorophyllin was docked with the antigen I/II (AgI/II) protein of S. mutans to evaluate its antimicrobial mechanism. The chemical structure and canonical SMILES format of Chlorophyllin were obtained from PubChem. Additionally, adsorption, distribution, metabolism, excretion, and toxicity (ADMET) analyses of Chlorophyllin were performed using ADMETlab 2.0 to assess its pharmacokinetic properties. Results: An agar well diffusion assay revealed that all S. mutans isolates were susceptible to Chlorophyllin extract and showed a variety of inhibition zones ranging from 32 to 41 mm. Chlorophyllin reduces the biofilm strength of four isolates from strong to moderate and six from strong to weak. The antibiofilm potential of Chlorophyllin was measured by a reduction in the number of functional groups observed in the Fourier Transform Infrared Spectrometer (FTIR) spectra of the extracellular polymeric substance (EPS) samples. Chlorophyllin showed binding with AgI/II proteins of S. mutans, which are involved in adherence to the tooth surface and initiating biofilm formation. The ADMET analysis revealed that the safety of Chlorophyllin exhibited favorable pharmacokinetic properties. Conclusions: Chlorophyllin stands out as a promising antibacterial and antibiofilm agent against biofilm-forming S. mutans, and its safety profile highlights its potential suitability for further investigation as a therapeutic agent. Full article

This study presents a cost-effective IoT-based Supervisory Control and Data Acquisition system for the real-time monitoring and control of photovoltaic systems in a rural Pakistani community. The system utilizes the Blynk platform with Arduino Nano, GSM SIM800L, and ESP-32 microcontrollers. The key components include a ZMPT101B voltage sensor, ACS712 current sensors, and a Maximum Power Point Tracking module for optimizing power output. The system operates over both Global System for Mobile Communications and Wi-Fi networks, employing universal asynchronous receiver–transmitter serial communication and using the transmission control protocol/Internet protocol and hypertext transfer protocol for data exchange. Testing showed that the system consumes only 3.462 W of power, making it highly efficient. With an implementation cost of CAD 35.52, it offers an affordable solution for rural areas. The system achieved an average data transmission latency of less than 2 s over Wi-Fi and less than 5 s over GSM, ensuring timely data updates and control. The Blynk 2.0 app provides data retention capabilities, allowing users to access historical data for performance analysis and optimization. This open-source SCADA system demonstrates significant potential for improving efficiency and user engagement in renewable energy management, offering a scalable solution for global applications. Full article

Precoding is a technique employed to enhance transmission rates in various communication systems, including massive multiple-input multiple-output (MIMO) and optical wireless communication (OWC). In this study, we focus on network massive MIMO OWC (NM-MIMO-OWC) systems and investigate the precoder design to enhance the sum rate and improve the system performance. We present the network’s massive MIMO OWC framework. By utilizing this framework, we are able to calculate the achievable sum rate. Subsequently, we consider the precoding design for maximizing the sum rate while adhering to the total power constraint. To solve this optimization problem, we provide a necessary condition of the optimal solution based on the Karush–Kuhn–Tucker (KKT) conditions, and propose a low-complexity algorithm to further enhance the efficiency of the proposed precoding technique. The numerical results demonstrate that the proposed precoder design significantly improves the transmission rate and effectively maximizes the sum rate. Full article

This paper analyzes dynamic modeling for rural HPS to address GHG emissions’ environmental impact on floods and climate change. The aim is to integrate renewable energy sources, such as solar energy, with traditional generators to mitigate emissions and enhance energy access in rural communities in Pakistan. The system is designed using a DC-DC converter, MPPT, LCL filter, and a DC-AC inverter. Utilizing software tools like PVsyst 7.4 and HOMER Pro-3.18.1, the study evaluates system sizing, energy consumption patterns, and optimization strategies tailored to site-specific data. The expected results include a reliable, environmentally friendly hybrid power system capable of providing consistent electricity to rural areas. The analysis of a connected load of 137.48 kWh/d and a peak load of 33.54 kW demonstrates the system’s promise for reliable electricity with minimal environmental impact. The estimated capital cost of USD 102,310 and energy generation at USD 0.158 per unit underscores economic feasibility. Dynamic modeling and validation using HIL examine the system’s behavior in response to variations in solar irradiance and temperature, offering insights into operational efficiency and reliability. The study concludes that the hybrid power system is scalable for rural energy access, which is a practical solution achieving a 100% renewable energy fraction, significantly contributing to emission reduction and promoting sustainable energy practices. Full article

In the last decade, permanent magnet (PM)-free or hybrid PM machines have been extensively researched to find an alternative for high cost rare-earth PM machines. Brushless wound rotor synchronous machines (BL-WRSMs) are one of the alternatives to these PM machines. BL-WRSMs have a lower torque density compared to PM machines. In this paper, a new topology is introduced to improve the torque producing capability of the existing BL-WRSM by utilizing the vacant spaces in the rotor slots. The new topology has two harmonic windings placed on the rotor which induce separate currents. A capacitor is used between the two harmonic windings to bring the currents in phase with each other. The harmonic winding currents are fed to the rectifier which is also placed on the rotor. Due to additional harmonic winding, the overall field current fed to the rotor field winding has been increased and hence the average torque has also increased. Finite element analysis (FEA)-based simulations are performed using ANSYS Maxwell to validate the proposed topology. The results show that the average torque of the machine has been significantly increased compared to the reference model. The detailed comparison results are provided in this paper. Full article