Search Results (23)

Desertification is among the most severe environmental problems in many countries at present, and threatens the integrity of natural environments and the sustainability of related natural resources. This work aims to assess proneness to desertification in the Alta Murgia karst plateau (Apulia, Southern Italy) through the integration of the modified Mediterranean Desertification and Land Use model (MEDALUS) with a GIS-based approach. The model includes indexes for climate, vegetation, soil, and management, all combined to assess environmentally sensitive areas (ESAs) regarding desertification. Given the karst features of the study area, the management index was modified and renamed the Karst Management Quality Index (KMQI). This modification was made by incorporating the Karst Disturbance Index (KDI), based on a series of indicators divided into five categories: geomorphology, hydrology, atmosphere, biota, and cultural factors. According to the model, the results indicated that the whole area (97%) is within the Critical type of ESA, with no area being assessed as the “Non-Affected” or “Potential” type. A total of 57% of the study area falls into Critical sub-type 2, 32% falls into sub-type 3, and 8% falls into sub-type 1. The remaining percentage (3%) belong to a non-optimal category, i.e., the Fragile type (sub-type F3) class. The obtained results could be explained, more than by climatic or ecological factors, by a series of anthropogenic activities carried out over the years that strongly modified and disturbed the original karst landscape, with a highly negative impact on the Alta Murgia karst. Full article

We analyze the variation in groundwater budget by modeling an aquifer in a semi-arid region in southern Italy, using different good pumping scenarios. This aquifer is overexploited due to the agricultural vocation of the area. We propose an integrated method to assess the distribution of hydrogeological parameters and the recharge rates. The hydrogeological parametrization is performed through a hydrostratigraphic approach using the geostatistical tool. Recharge rates are computed through a soil water balance application, using different monitoring stations over the area for the whole period of interest. Integrating the results of this analysis with pumping scenarios based on the water irrigation requirement of the main crops in the area, different water budgets are estimated. The results show how different pumping scenarios affect the availability of water resources and thus underline the importance of management. This integrated hydrogeological model can be applied to other areas with similar hydrogeological characteristics, and it can be considered a valuable tool for evaluating sustainable groundwater management strategies, considering land use practices and socio-economic factors. Full article

Background: Long COVID-19 is an emerging chronic illness of significant public health concern due to a myriad of neuropsychiatric sequelae, including increased suicidal ideation (SI) and behavior (SB). Methods: This review provides a concise synthesis of clinical evidence that points toward the dysfunction of astrocytes, the most abundant glial cell type in the central nervous system, as a potential shared pathology between SI/SB and COVID-19. Results: Depression, a suicide risk factor, and SI/SB were both associated with reduced frequencies of various astrocyte subsets and complex proteomic/transcriptional changes of astrocyte-related markers in a brain-region-specific manner. Astrocyte-related circulating markers were increased in depressed subjects and, to a less consistent extent, in COVID-19 patients. Furthermore, reactive astrocytosis was observed in subjects with SI/SB and those with COVID-19. Conclusions: Astrocyte dysfunctions occurred in depression, SI/SB, and COVID-19. Reactive-astrocyte-mediated loss of the blood–brain barrier (BBB) integrity and subsequent neuroinflammation—a factor previously linked to SI/SB development—might contribute to increased suicide in individuals with long COVID-19. As such, the formulation of new therapeutic strategies to restore astrocyte homeostasis, enhance BBB integrity, and mitigate neuroinflammation may reduce SI/SB-associated neuropsychiatric manifestations among long COVID-19 patients. Full article

Carbonate rocks cover about 23% of Albania, with exploitable karst water resources estimated at 2.84 × 10⁹ m³/year (about 65% of the total exploitable groundwater resources in the country). The Kruja tectonic zone is characterized by the presence of SE–NW-oriented carbonate structures, rich in fresh and thermal groundwaters. More than 80% of the thermal springs in Albania are present in this tectonic zone. One of its most interesting carbonate structures, with the presence of both cold and thermal waters, is the small karst structure of Makaresh, with a surface of 22 km². The purpose of this article is to describe the hydrogeological characteristics of this massif; based on the physico-chemical characteristics, groundwaters of the study area are classified as cold waters (belonging to the local flow system) and thermal waters (originating in intermediate/deep flow systems). The former are mainly of HCO₃-Ca or HCO₃-Ca-Mg type (electrical conductivity 580–650 μS/cm, Temperature 13.9–16.6 °C). Thermal waters are mainly of the Cl-Na-Ca type (EC 7200–7800 μS/cm, T 18.5–22.5 °C); they are further characterized by high hydrogen sulfide concentration, up to about 350 mg/L. The presence of two groundwater types in the Makaresh massif is connected to the presence of two groundwater circulation systems. The main factors of the groundwater physico-chemical quality are the dissolution of rocks and minerals contained therein, the presence of hypogenic speleogenesis, and the mixing of the groundwater of the two systems. The hydrogeological studies proved that karst rocks contain considerable freshwater resources, partly used for water supply. Thermal waters are not currently exploited due to their temperature, but they are potentially suitable for thermal uses by drilling boreholes to a depth of about 1000 m. Full article

A chronotype is generally defined as the variability of the phase angle of entrainment, while the latter reflects the relationship between the timing of a certain rhythm (e.g., the sleep–wake cycle) and the timing of an external temporal cue. Individuals can be placed on a spectrum from “morning types” (M types) to “evening types” (E types). E-chronotype has been proposed as a transdiagnostic risk factor for psychiatric conditions, and it has been associated with psychopathological dimensions. Eveningness seems to be correlated with both suicidal ideation (SI) and suicidal behavior (SB) through several possible mediating factors. Immunological alterations have also been linked to later chronotypes and SI/SB. This narrative review aims to summarize the evidence supporting the possible association between chronotypes and suicide and the eventual mediating role of neuroinflammation and several psychopathological dimensions. A search of the literature (2003–2023) was conducted using various databases: PUBMED, EMBASE, Scopus, UpToDate, PsycINFO, and Cochrane Library. English-language articles were collected and screened for eligibility. Despite the apparent absence of a direct correlation between E-chronotype and suicidality, E-chronotype promotes a chain of effects that could be involved in an increased risk of SB, in which with neuroinflammation possibly plays an intriguing role and some psychopathological dimensions may stand out. Full article

Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia. Full article

Gravaglione represents one of the main swallow holes of the Canale di Pirro, low Murge, Apulia region, Italy. Here, after an intense rainstorm, a huge volume of rainwater accumulates at the surface. The drainage dynamics suggest that the Gravaglione could be part of a large, and potentially unknown, karst system. To verify this hypothesis and to acquire useful information on the possible karst environment features, an integrated aerial and geophysical multiscale and multimethod approach was applied. In particular, aerial photogrammetry, ground penetrating radar measurements and electrical resistivity tomography surveys were hence conducted and integrated to potentially detect the caves, define the subsurface volume possibly affected by karst systems and to verify the existence of links between the surficial morphology and the subsoil structure. The results provided interesting insights regarding the presence of a complex karst system extending up to 200 m b.g.l. and with a marked 3D nature. Overall, the Gravaglione case study demonstrates the geophysical approach validity and poses the basis for the development of an expeditive and low-cost high-resolution strategy for detecting and characterizing karst caves. Full article

At the end of November 2021, a large area of Puglia (an administrative region in Southern Italy) was officially nominated as new aUGGp (aspiring UNESCO Global Geopark) by the Italian National Commission of UNESCO. This area comprises the northwestern part of the Murge territory, where a Cretaceous sector of the Apulia Carbonate Platform crops out, and part of the adjacent Premurge territory, where the southwestward lateral continuation of the same platform (being flexed toward the Southern Apennines Chain) is covered by thin Plio-Quaternary foredeep deposits. The worldwide geological uniqueness of the aspiring Geopark (Murge aUGGp) is that the area is the only in situ remnant of the Adria Plate, the old continental plate almost entirely squeezed between the Africa and Eurasia Plates. In such a context, the Murge area (part of the Apulia Foreland) is a virtually undeformed sector of Adria, while other territories of the plate are and/or were involved in the subduction/collision processes. In the aspiring Geopark, the crust of Adria is still rooted to its mantle, and the Cretaceous evolution of the continent is widely recorded in the Murge area thanks to the shallow-water carbonate succession of one of the largest peri-Tethys carbonate platforms (the Apulia Carbonate Platform). The aspiring Geopark also comprises the Premurge area, which represents the outer Southern Apennines foredeep, whose Plio-Quaternary evolution is spectacularly exposed thanks to an “anomalous” regional middle-late Quaternary uplift. Despite the presence of numerous geological singularities of international importance, it would be important, from a geotourist point of view, to propose a regional framework of the geology of the aUGGp before introducing visitors to the significance of the individual geosites, whose importance could be amplified if included in the geoevolutionary context of the Murge aUGGp. Full article

In December 2013, a portion of a large and deep ancient landslide on the southern slope of the Montescaglioso town (Basilicata, Southern Italy) was abruptly reactivated, as a consequence of exceptional rainfall events, causing relevant damages to structures and infrastructures. The sliding surface is supposed to be located within a thick deposit of Pleistocene stiff clays overlain by dislocated blocks of calcarenites and cemented conglomerates. This paper discusses the research carried out to investigate the failure mechanism that occurred during the landslide event and the factors that controlled the reactivation. To this purpose, geological and geomorphological analyses were first proposed, followed by a back-analysis of the landslide process, performed via limit equilibrium calculations implementing time-dependent pore water pressure distributions derived from transient seepage finite element analyses. Furthermore, the overall landslide mechanism was investigated through a three-dimensional finite element analysis, built using the monitoring campaign carried out in the post-failure stage and calibrated according to the in situ failure mechanism evidence. Both the limit equilibrium and finite element analyses provide results in good agreement with the geomorphological evidence, further allowing us to recognize the effects of rainfall infiltration in the increase of pore water pressure along the sliding surface and the variation of the stress–strain state leading to failure occurrence. Full article

Terra rossa is a reddish clay soil which is often present on the surface of limestone in regions with a Mediterranean-type climate. Its genesis is a controversial subject in terms of the origin of the parent material, from the residuum of underlying (carbonate/dolomite) bedrock in the absence/presence of an external silicate contribution (e.g., aeolian dust). Within this context the main goal of the present work was the understanding of the geochemical processes leading to the formation of the terra rossa starting from the carbonate bedrock. We report the results of a multi-method analysis on a terra rossa deposit occupying the bottom of a Quaternary karst depression on Mesozoic limestones exposed in the Murge area (Apulia Foreland, southern Italy). Geological, petrographic, textural, and chemical data were collected on karst products (reddish calcite incrustations and nodules, and fine-grained portion of terra rossa) by a detailed field mapping, optical microscopy, XRF and fusion ICP/MS analyses and by scanning electron microscope. New collected data show that the mineralogical composition of reddish incrustations and nodules is comparable, consisting of fibrous and impure calcite, detrital fragments of quartz, K-feldspar, zircon and authigenic minerals as (Mn, Ba, Ca) phases, (Al, Si, Mn, Fe, Mg, Ba, Ca) minerals, Fe-kaolinite and anatase. The prevailing minerals, instead, in the fine-grained portion of terra rossa are hematite, kaolinite, and goethite. Based on the chemical composition, and especially on REE patterns, a progressive interaction of silicate aqueous solutions (with Al, Si, Fe), containing pelite material, with the calcareous bedrock, as a source of carbonic acid, was the process driving the formation of terra rossa. Obtained results add new elements to the definition of the long-lasting question about the genetic processes responsible for the formation of terra rossa, corroborating their polygenetic origin, as result of limestone alteration in conjunction with the chemical interaction with allochthonous siliciclastic material. Full article

Background: The aim of this study is to compare sublingual sufentanil and the administration device for its delivery (SSST-Zalviso^®) with the traditional strategies used for the control of postoperative pain to establish if there is an actual benefit for the patient and healthcare personnel. Materials and Methods: A retrospective study was conducted to compare the efficacy of SSTS in the management of postoperative pain after orthopedic surgery between October 2018 and June 2020. We analyzed 50 patients who underwent a total knee arthroplasty (TKA). The control group consisted of 21 patients who underwent TKA and during the hospitalized recovery received a continuous femoral nerve block (cFNB). The statistical study was conducted with a level of significance p = 0.05 using “U” test, Mann–Whitney, to verify if patients had a better control of pain and fewer calls for rescue analgesia. Results: Patients involved in the study showed a significant reduction in pain intensity with the use of SSTS in the 24 h following surgery (p = 0.0568), also a drastic drop of the calls for rescue analgesia (p < 0.0001) reduces the number of calls for its control. Conclusions: This study demonstrates how SSTS might reduce pain intensity in the first 24 h after surgery and reduce the number of calls for its control, indicating better analgesic coverage and implying reduced interventions from healthcare personnel. This could allow a redistribution of resources and a reduction in the use of analgesic drugs in wards where the SSTS is used. Full article

Karst regions are peculiar due to their environmental and ecological features and hold a rich abundance of natural resources; nonetheless, they represent one of the most endangered areas in the world as a result of human activity. Further, urbanization and modernization of agricultural practices over the years determined an acceleration in the degradation of the karst environment. For a long period in the Apulia region, humans used to live in a sustainable equilibrium with the karst landscape; however, during the 1980s and 1990s, an intense conversion of land cover interested the area, determining a high disturbance of the karst landforms and landscape degradation. In this article, we propose an insight into a case study placed in the Alta Murgia area (Apulia, Italy) to analyze the evolution of the karst landscape over a period of 50 years (1954–2006) by means of geomorphological analysis and multi-temporal photo interpretation. Landcover mapping is carried out to catch landscape modification, and further, obliteration of the karst features through time is also detected. Changes are quantified, and related statistics are derived. Furthermore, to better characterize the area, the main morphometric parameters are also computed for doline. Finally, extensive fieldwork is carried out to verify the current state of the mapped elements and to check the most peculiar observed cases of land cover and karst landform transformations. Results show the intensive transformation experienced by the study site in the period 1973–2006, determined by the substantial land cover transition from pasture and permanent crops to cultivated areas. Further, the main karst features, such as doline and shallow valleys with flat bottoms, also locally known as lame, are partially or totally obliterated by agricultural practices. Full article

The territory of Albania presents wide outcrops of soluble rocks, with typical karst landforms and the presence of remarkable carbonate aquifers. Many karst areas are located near the coasts, which results in a variety of environmental problems, mostly related to marine intrusion. This paper focuses on the brackish springs of Albania, which exhibit temperatures approximately equal to the yearly air temperature at their location. Total dissolved solids of the springs are higher than 1000 mg/L, their waters are not drinkable, and they are rarely used for other purposes. The groundwater of the alluvial aquifers of Albania, particularly those of Pre-Adriatic Lowland, are often brackish too, but these will not be addressed here. Brackish springs of Albania are mainly of karst origin and can be classified into two groups: springs in evaporitic rock, mainly gypsum, and springs in carbonate rock. The hydro-chemical facies of the first group are usually Ca-SO₄, locally with increased concentrations of Na-Cl, whereas springs belonging to the second group usually exhibit Na-Cl facies. The largest brackish springs of Albania are described in detail, including their hydro-chemical correlations. Full article

Sinkholes are a widespread geological hazard, typical of karst lands, where they generally originate as collapse features related to presence of underground voids. Nevertheless, other types of sinkholes can be formed through solution, suffusion and sagging processes. Sinkholes can also be originated in relation to artificial cavities, excavated by man in past times. In Italy, sinkholes interest large sectors of the country, given the very long history of Italy with an intense utilization of the underground. They cause serious damage to infrastructures, economic activities, and human health every year. We present a catalogue on natural and anthropogenic sinkholes in Italy, as the first step toward evaluation of the sinkhole hazard. After introducing sinkholes, which is definitely a highly underrated type of disaster in Italy, we point out their occurrence in the country. We illustrate the methodology used to build the database, with particular focus on accuracy and reliability of the data. Collecting information from different types of sources, a catalogue of some 1190 sinkhole events is built. Database structure and data analysis are then illustrated. Eventually, we draw some conclusions on the likely uses of our work by providing recommendations for environmental management on this very delicate issue. Full article

Local ablative therapy (LAT), intended as stereotactic ablative radiotherapy or stereotactic radiosurgery, is a well-recognized effective treatment for selected patients with oligometastatic NSCLC. Current clinical evidence supports LAT alone or in combination with systemic therapies. Our retrospective mono-institutional study aims to assess the role of LAT with a peculiar focus on the largest series of non-oncogene addicted oligometastatic NSCLC patients to date. We included in this analysis all patients with the mentioned disease characteristics who underwent LAT for intracranial and/or extracranial metastases between 2011 and 2020. The main endpoints were local control (LC), progression free survival (PFS) and overall survival (OS) in the whole population and after stratification for prognostic factors. We identified a series of 245 consecutive patients (314 lesions), included in this analysis (median age 69 years). In 77% of patients, a single metastasis was treated with LAT and intracranial involvement was the most frequent indication (53% of patients) in our series. The overall response rate (ORR) after LAT was 95%. In case of disease progression, 66 patients underwent new local treatments with curative intent. With a median follow-up of 18 months, median PFS was 13 months (1-year PFS 50%) and median OS was 32 months (1-year OS 75%). The median LC was not reached (1-year LC 89%). The presence of brain metastases was the only factor that negatively affected all clinical endpoints, with a 1-year LC, PFS and OS of 82%, 29% and 62% respectively, compared to 95%, 73% and 91%, respectively, for patients without BMs (p < 0.001 for each endpoint). At the multivariate analysis, mediastinal nodal involvement at baseline (p = 0.049), ECOG PS = 1 (p = 0.011), intracranial disease involvement (p = 0.001), administration of chemotherapy in combination with LAT (p = 0.020), and no delivery of further local treatment for progression or delivery of focal treatment for intracranial progression (p < 0.001) were related to a poorer OS. In our retrospective series, which is to our knowledge the largest to date, LAT showed encouraging results and confirmed the safety and effectiveness of focal treatments in non-oncogene addicted oligometastatic NSCLC patients. Full article