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Search Results (6)

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Authors = Isabel Trapero ORCID = 0000-0001-7531-6825

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20 pages, 291 KiB  
Article
Experiences of Second-Grade Primary School Children and Their Teachers in a Mind–Body Activity Program: A Descriptive Qualitative Study
by Yaiza Lopez-Sierra, Sara Trapero-Asenjo, Isabel Rodríguez-Costa, Gonzalo Granero-Heredia, Yolanda Pérez-Martin and Susana Nunez-Nagy
Healthcare 2024, 12(20), 2095; https://doi.org/10.3390/healthcare12202095 - 21 Oct 2024
Cited by 1 | Viewed by 1788
Abstract
Objectives: This study explored the experiences of second-grade children and their teachers who participated in a mind–body program to understand its impact on their development. Methods: A qualitative descriptive study was conducted. Student data were collected through seven focus groups, and semi-structured interviews [...] Read more.
Objectives: This study explored the experiences of second-grade children and their teachers who participated in a mind–body program to understand its impact on their development. Methods: A qualitative descriptive study was conducted. Student data were collected through seven focus groups, and semi-structured interviews were conducted with tutors in December 2021. Data analysis was performed following COREQ guidelines. Results: Three themes were generated: (1) competitiveness and restlessness in children: something needs to be done; (2) seeds sown and fruits harvested; and (3) it is necessary to advance from the occasional to the structural. Participants reported positive changes in areas of their development such as self-regulation, relaxation, attention capacity, and stress reduction. Improvements in interpersonal relationships and social skills were also observed. Conclusions: These improvements in emotional well-being and social skills highlight the importance of this type of intervention in the school environment. Full article
(This article belongs to the Special Issue New Insights into Understudied Phenomena in Healthcare)
11 pages, 457 KiB  
Article
Circadian Variations and Associated Factors in Patients with Ischaemic Heart Disease
by Marisa Estarlich, Carmen Tolsa, Isabel Trapero and Cristina Buigues
Int. J. Environ. Res. Public Health 2022, 19(23), 15628; https://doi.org/10.3390/ijerph192315628 - 24 Nov 2022
Cited by 6 | Viewed by 1966
Abstract
Circadian rhythms have been identified in cardiovascular diseases, and cardiovascular risk factors can modify the circadian rhythm. The purpose of this study was to describe the onset of ischaemic heart disease symptomatology in relation to the date and time, the day of the [...] Read more.
Circadian rhythms have been identified in cardiovascular diseases, and cardiovascular risk factors can modify the circadian rhythm. The purpose of this study was to describe the onset of ischaemic heart disease symptomatology in relation to the date and time, the day of the week of presentation, the season, AMI location and severity and the level of influence of individual patient characteristics in a retrospective cross-sectional study involving 244 ischaemic heart disease patients from the intensive care unit of La Ribera Hospital (Spain). The onset of pain was more frequent in the morning, the season with the highest frequency of ischaemic events was winter, and the lowest incidence was during weekends. Regarding the severity of ischaemic heart disease, the circadian rhythm variables of weekdays vs. weekends and seasons did not show a significant association. The length of hospital stay was associated with the onset of pain in the afternoon. The onset of pain at night was associated with the subendocardial location of the infarction. In conclusion, living in a Mediterranean country, the Spanish population showed a circadian pattern of AMI, where the onset of pain has an influence on AMI location and on the length of hospital stay and is the same in patients with different individual risk factors. Full article
(This article belongs to the Special Issue Myocardial Infarction: Prevention and Treatment)
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15 pages, 855 KiB  
Review
Interleukin Inhibitors in Cytokine Release Syndrome and Neurotoxicity Secondary to CAR-T Therapy
by Puri Ferreros and Isabel Trapero
Diseases 2022, 10(3), 41; https://doi.org/10.3390/diseases10030041 - 6 Jul 2022
Cited by 14 | Viewed by 4361
Abstract
Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy is an innovative therapeutic option for addressing certain recurrent or refractory hematological malignancies. However, CAR-T cells also cause the release of pro-inflammatory cytokines that lead to life-threatening cytokine release syndrome and neurotoxicity. Objective: To study the [...] Read more.
Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy is an innovative therapeutic option for addressing certain recurrent or refractory hematological malignancies. However, CAR-T cells also cause the release of pro-inflammatory cytokines that lead to life-threatening cytokine release syndrome and neurotoxicity. Objective: To study the efficacy of interleukin inhibitors in addressing cytokine release syndrome (CRS) and neurotoxicity secondary to CAR-T therapy. Methodology: The authors conducted a bibliographic review in which 10 articles were analyzed. These included cut-off studies, case reports, and clinical trials involving 11 cancer centers and up to 475 patients over 18 years of age. Results: Tocilizumab is the only interleukin inhibitor approved to address CRS secondary to CAR-T therapy due to its efficacy and safety. Other inhibitors, such as siltuximab and anakinra, could be useful in combination with tocilizumab for preventing severe cytokine release and neurotoxicity. In addition, the new specific inhibitors could be effective in mitigating CRS without affecting the cytotoxic efficacy of CAR-T therapy. Conclusion: More lines of research should be opened to elucidate the true implications of these drugs in treating the side effects of CAR-T therapy. Full article
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12 pages, 1311 KiB  
Article
Salivary IL-6 Concentration Is Associated with Frailty Syndrome in Older Individuals
by Pablo Gómez-Rubio, Isabel Trapero, Omar Cauli and Cristina Buigues
Diagnostics 2022, 12(1), 117; https://doi.org/10.3390/diagnostics12010117 - 5 Jan 2022
Cited by 12 | Viewed by 2611
Abstract
Background: One of the physiological changes that is most closely associated with frailty is the increase in pro-inflammatory cytokines, and IL-6 in particular. Most studies have demonstrated this association using blood samples. We analyzed the relationship between frailty syndrome, individual frailty criteria, and [...] Read more.
Background: One of the physiological changes that is most closely associated with frailty is the increase in pro-inflammatory cytokines, and IL-6 in particular. Most studies have demonstrated this association using blood samples. We analyzed the relationship between frailty syndrome, individual frailty criteria, and IL-6 levels obtained by saliva tests. Methods: A cross-sectional pilot study was performed among women institutionalized in nursing homes. Frailty was defined as having three or more of the following components: low lean mass, weakness, self-reported exhaustion, low activity level, and slow walking speed; prefrailty was defined as having one or two of those components. Results: There was a significant and positive correlation between the frailty score and salivary IL-6 concentration. Regarding the associations between IL-6 and individual dichotomized frailty criteria, there were significant differences in salivary IL-6 concentration in two frailty criteria: weight loss (p = 0.002) and low physical activity (p = 0.007). Receiver operating characteristic curve analysis showed that IL-6 concentration significantly (p < 0.05) (although moderately) discriminated patients that progressed in the frailty syndrome (the area under the curve value was 0.697 with 95% CI 0.566–0.827). Conclusions: Salivary IL-6 concentration can be used as potential biomarker of frailty syndrome and as a tool to monitor the effects of interventions in frail individuals. Full article
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17 pages, 2751 KiB  
Article
Psycho-Social Factors in Patients with Cardiovascular Disease Attending a Family-Centred Prevention and Rehabilitation Programme: EUROACTION Model in Spain
by Cristina Buigues, Ana Queralt, Jose Antonio De Velasco, Antonio Salvador-Sanz, Catriona Jennings, David Wood and Isabel Trapero
Life 2021, 11(2), 89; https://doi.org/10.3390/life11020089 - 26 Jan 2021
Cited by 6 | Viewed by 4787
Abstract
Background: Coronary heart disease (CHD) persists as the leading cause of death worldwide. Cardiovascular prevention and rehabilitation (CVPR) has an interdisciplinary focus, and includes not only in physiological components, but it also addresses psycho-social factors. Methods: The study analysed the Spanish psycho-social data [...] Read more.
Background: Coronary heart disease (CHD) persists as the leading cause of death worldwide. Cardiovascular prevention and rehabilitation (CVPR) has an interdisciplinary focus, and includes not only in physiological components, but it also addresses psycho-social factors. Methods: The study analysed the Spanish psycho-social data collected during the EUROACTION study. In Spain, two hospitals were randomised in the Valencia community. Coronary patients were prospectively and consecutively identified in both hospitals. The intervention hospital carried out a 16-week CVPR programme, which aimed to assess illness perceptions and establish healthy behaviours in patients and their partners. Results: Illness perceptions were significantly and inversely associated with anxiety and depression. Low levels of anxiety were associated with better self-management of total cholesterol (p = 0.004) and low-density lipoprotein-cholesterol (p = 0.004). There was concordance at one year among patients and partners who participated in the programme related to anxiety (p < 0.001), fruit consumption (p < 0.001), and vegetable consumption (p < 0.001). Conclusions: The EUROACTION study emphasised the importance of assessing psycho-social factors in a CVPR programme and the inclusion of family as support in patients’ changes in behaviour. Full article
(This article belongs to the Special Issue Mental Health Issues and Quality of Life in Older Individuals)
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11 pages, 907 KiB  
Review
The Effects of Exercise on IL-6 Levels and Cognitive Performance in Patients with Schizophrenia
by Pablo Gómez-Rubio and Isabel Trapero
Diseases 2019, 7(1), 11; https://doi.org/10.3390/diseases7010011 - 22 Jan 2019
Cited by 28 | Viewed by 6406
Abstract
Exercise plays an important role in brain plasticity, leading to improvements in cognitive function and delaying the cognitive deterioration of healthy people. These effects can be observed in individuals with schizophrenia through improvements in their performance in cognitive tasks and a decrease in [...] Read more.
Exercise plays an important role in brain plasticity, leading to improvements in cognitive function and delaying the cognitive deterioration of healthy people. These effects can be observed in individuals with schizophrenia through improvements in their performance in cognitive tasks and a decrease in the symptomology of the disease. In this review we examine the current evidence for the roles that exercise and the immune system play in patients with schizophrenia, and specifically analyze the interleukin-6 (IL-6) pathway as a potential mechanism resulting in these positive effects. Inflammation and high levels of IL-6 are associated with both the severity of schizophrenia and the cognitive impairment suffered throughout the disease. Performing regular exercise can modulate IL-6 by lowering its basal levels and by causing lower acute increases in the plasma levels of this cytokine in response to exercise (an anti-inflammatory response to physical exertion). Although there is evidence for the positive effects of physical exercise on schizophrenia, more studies will be required to better understand how variation in different exercise parameters affects both the acute and chronic plasma levels of IL-6. Full article
(This article belongs to the Special Issue Neuro-psychiatric Disorders - from Diagnosis to Care)
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