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Pesticides in Water and Health

A special issue of Water (ISSN 2073-4441). This special issue belongs to the section "Water and One Health".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1498

Special Issue Editors

Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA
Interests: metabolomics; lipidomics; exposomics; gut microbiota; environmental health; prediabetes; obesity; Alzheimer's disease

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Guest Editor
College of Environment, Hohai University, Nanjing 210098, China
Interests: chiral antibiotics; amphibians; aquatic ecological risk assessment

Special Issue Information

Dear Colleagues,

This Special Issue invites contributions that investigate the presence of pesticide residues in aquatic environments and their potential direct and indirect impacts on human health. We welcome submissions in the following two main areas—or studies that integrate both:

The first area focuses on the monitoring and quantification of pesticide residues in surface and groundwater across various geographic regions. Submissions that include biota sampling—such as fish, amphibians, or aquatic invertebrates—to assess bioaccumulation and trophic transfer within contaminated ecosystems are especially encouraged. Non-invasive sampling approaches are also welcome.

The second area centers on the toxicological and health risk assessment of pesticides detected in real-world water samples. Both in vitro and in vivo studies are invited. In vitro studies should examine (1) cytotoxicity across multiple human cell lines and (2) comparative impacts on individual gut microbial strains versus complex microbial communities. In vivo studies may include aquatic organisms to evaluate biomagnification and food web transfer, as well as mammalian models (e.g., mice) to assess chronic toxicity and metabolic disruption.

This Special Issue seeks to bridge environmental monitoring with human health research, providing an integrated perspective on how pesticide-contaminated water affects ecological systems and long-term public health.

Dr. Li Chen
Dr. Wenjun Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Water is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pesticide
  • bioaccumulation
  • toxicological assessment
  • health risk assessment
  • in vitro
  • in vivo

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Published Papers (1 paper)

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Research

22 pages, 2756 KB  
Article
Integrating Ecotoxicological Assessment to Evaluate Agricultural Impacts on Aquatic Ecosystems: A Case Study of the Lage Reservoir (Mediterranean Region)
by Adriana Catarino, Clarisse Mourinha, Mariana Custódio, Pedro Anastácio and Patrícia Palma
Water 2025, 17(17), 2642; https://doi.org/10.3390/w17172642 - 6 Sep 2025
Viewed by 835
Abstract
This study analyzed the use of a toolbox to evaluate the impact of agricultural activity on the water quality/status classification of a hydro-agricultural reservoir (Lage reservoir, Southern Portugal). The framework integrated the quantification of a group of 51 pesticides and ecotoxicological endpoints with [...] Read more.
This study analyzed the use of a toolbox to evaluate the impact of agricultural activity on the water quality/status classification of a hydro-agricultural reservoir (Lage reservoir, Southern Portugal). The framework integrated the quantification of a group of 51 pesticides and ecotoxicological endpoints with organisms from different trophic categories (the bacterium Aliivibrio fischeri, the microalga Pseudokirchneriella subcapitata, and the crustaceans Daphnia magna and Thamnocephalus platyurus) at two sampling points in the reservoir (Lage (L) and Lage S (LS)) between 2018 and 2020. Over the three-year study, we quantified 36 of the 51 pesticides analyzed in the Lage reservoir. Total concentrations increased successively from 0.95 µg L−1 to 1.99 and 2.66 µg L−1. Among these, the pesticides most frequently detected were terbuthylazine (100% of detection) and metolachlor (83% of detection), with maximum concentrations of 115.6 and 85.5 µg L−1, respectively. Samples from the LS site showed higher toxicity, where A. fischeri presented 30 min EC50 values of 39–51%. Microalgae growth was consistently inhibited, correlating with agricultural activity, mainly the application of herbicides and insecticides, while D. magna feeding rates revealed no inhibitory effects in the Lage samples. The results highlight that although the detected pesticide levels were below regulatory limits, they still induced toxic effects in the tested organisms. The potential ecological status of the reservoir was classified as moderate, and the integration of the proposal toolbox allowed refinement of the classification of water status. The results demonstrated that this integrated approach, combining multiple assessment methods, establishes a more robust water quality evaluation methodology, allowing it to be used as a tool complementary to the WFD methodology. This proposal not only identified existing pollution impacts but also enabled (1) early detection of the toxic effects of emerging contaminants to prevent ecological damage; (2) proactive management through specific actions to restore water status; and (3) improved sustainable water use. Full article
(This article belongs to the Special Issue Pesticides in Water and Health)
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