Special Issue "Dendritic Cells and Antiviral Defense"
Deadline for manuscript submissions: closed (15 November 2019).
Interests: vaccination and therapy for influenza in the nonhuman primate model; dendritic cells and macrophages in simian immunodeficiency virus infection of nonhuman primates; pathogenesis of dengue and Zika virus infections in humans
Interests: role of dendritic cells in the induction and regulation of innate and adaptive immunity; impact of pathogens on human dendritic cell phenotype and function; ex vivo generation and programming of human dendritic cells for the purpose of developing effective cellular based immunotherapies to treat chronic diseases including cancer and HIV
Dendritic cells are key mediators of innate immunity and play an integral role in inducing adaptive immune responses to viruses. Specialized subsets of dendritic cells serve diverse functions, from capturing antigen in peripheral tissues and migrating to lymph nodes where they engage antigen-specific T cells, to producing copious quantities of type-I interferon in response to virus infection. Dendritic cell-based immunotherapy for viral infections is beginning to show promise following the implementation of this strategy to treat cancer. However, dendritic cells are also targets of immune evasion strategies by viruses and can serve as Trojan horses to facilitate virus spread in the host. In this review, we explore the varied contributions of this critical immune cell to antiviral immunity.
Dr. Simon M. Barratt-Boyes
Dr. Robbie B. Mailliard
Manuscript Submission Information
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- dendritic cell
- virus immunity
- therapeutic vaccination
- immune evasion