Contribution of Dendritic Cells in Protective Immunity against Respiratory Syncytial Virus Infection
1
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
2
Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon 51472, Korea
3
KAIST Institute for Health Science and Technology, KAIST, Daejeon 34141, Korea
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(1), 102; https://doi.org/10.3390/v12010102
Received: 29 November 2019
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Revised: 8 January 2020
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Accepted: 13 January 2020
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Published: 15 January 2020
(This article belongs to the Special Issue Dendritic Cells and Antiviral Defense)
Respiratory syncytial virus (RSV) is a major cause of severe respiratory disease in infants and the elderly. The socioeconomic burden of RSV infection is substantial because it leads to serious respiratory problems, subsequent hospitalization, and mortality. Despite its clinical significance, a safe and effective vaccine is not yet available to prevent RSV infection. Upon RSV infection, lung dendritic cells (DCs) detecting pathogens migrate to the lymph nodes and activate the adaptive immune response. Therefore, RSV has evolved various immunomodulatory strategies to inhibit DC function. Due to the capacity of RSV to modulate defense mechanisms in hosts, RSV infection results in inappropriate activation of immune responses resulting in immunopathology and frequent reinfection throughout life. This review discusses how DCs recognize invading RSV and induce adaptive immune responses, as well as the regulatory mechanisms mediated by RSV to disrupt DC functions and ultimately avoid host defenses.
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MDPI and ACS Style
Jung, H.E.; Kim, T.H.; Lee, H.K. Contribution of Dendritic Cells in Protective Immunity against Respiratory Syncytial Virus Infection. Viruses 2020, 12, 102. https://doi.org/10.3390/v12010102
AMA Style
Jung HE, Kim TH, Lee HK. Contribution of Dendritic Cells in Protective Immunity against Respiratory Syncytial Virus Infection. Viruses. 2020; 12(1):102. https://doi.org/10.3390/v12010102
Chicago/Turabian StyleJung, Hi E., Tae H. Kim, and Heung K. Lee. 2020. "Contribution of Dendritic Cells in Protective Immunity against Respiratory Syncytial Virus Infection" Viruses 12, no. 1: 102. https://doi.org/10.3390/v12010102
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