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When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses

1
IrsiCaixa AIDS Research Institute, Ctra. de Canyet s/n, 08916 Badalona, Spain
2
Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
3
Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, 08916 Badalona, Spain
4
Chair in Infectious Diseases and Immunity, Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain
5
Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Viruses 2020, 12(1), 8; https://doi.org/10.3390/v12010008
Received: 13 November 2019 / Revised: 4 December 2019 / Accepted: 5 December 2019 / Published: 19 December 2019
(This article belongs to the Special Issue Dendritic Cells and Antiviral Defense)
Dendritic cells (DCs) are among the first cells that recognize incoming viruses at the mucosal portals of entry. Initial interaction between DCs and viruses facilitates cell activation and migration to secondary lymphoid tissues, where these antigen presenting cells (APCs) prime specific adaptive immune responses. Some viruses, however, have evolved strategies to subvert the migratory capacity of DCs as a way to disseminate infection systemically. Here we focus on the role of Siglec-1, a sialic acid-binding type I lectin receptor potently upregulated by type I interferons on DCs, that acts as a double edge sword, containing viral replication through the induction of antiviral immunity, but also favoring viral spread within tissues. Such is the case for distant enveloped viruses like human immunodeficiency virus (HIV)-1 or Ebola virus (EBOV), which incorporate sialic acid-containing gangliosides on their viral membrane and are effectively recognized by Siglec-1. Here we review how Siglec-1 is highly induced on the surface of human DCs upon viral infection, the way this impacts different antigen presentation pathways, and how enveloped viruses have evolved to exploit these APC functions as a potent dissemination strategy in different anatomical compartments. View Full-Text
Keywords: Siglec-1; dendritic cells; HIV-1; Ebola virus; immune evasion Siglec-1; dendritic cells; HIV-1; Ebola virus; immune evasion
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MDPI and ACS Style

Perez-Zsolt, D.; Martinez-Picado, J.; Izquierdo-Useros, N. When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses. Viruses 2020, 12, 8.

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