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Rhabdoviruses, Antiviral Defense, and SUMO Pathway

INSERM UMR-S 1124, Université Paris Descartes, 75006 Paris, France
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS UMR 9198, Université Paris-Sud, 91190 Gif-sur-Yvette, France
Author to whom correspondence should be addressed.
Viruses 2018, 10(12), 686;
Received: 10 October 2018 / Revised: 13 November 2018 / Accepted: 28 November 2018 / Published: 3 December 2018
Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (SUMO1, 2, and 3). Infection by rhabdoviruses triggers cellular responses through the activation of pattern recognition receptors, which leads to the production and secretion of interferon. This review will focus on the effects of the stable expression of the different SUMO paralogs or Ubc9 depletion on rhabdoviruses-induced interferon production and interferon signaling pathways as well as on the expression and functions of restriction factors conferring the resistance to rhabdoviruses. View Full-Text
Keywords: interferon; rabies virus; vesicular stomatitis virus; IFN; SUMO; MxA; PKR interferon; rabies virus; vesicular stomatitis virus; IFN; SUMO; MxA; PKR
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MDPI and ACS Style

El Asmi, F.; Brantis-de-Carvalho, C.E.; Blondel, D.; Chelbi-Alix, M.K. Rhabdoviruses, Antiviral Defense, and SUMO Pathway. Viruses 2018, 10, 686.

AMA Style

El Asmi F, Brantis-de-Carvalho CE, Blondel D, Chelbi-Alix MK. Rhabdoviruses, Antiviral Defense, and SUMO Pathway. Viruses. 2018; 10(12):686.

Chicago/Turabian Style

El Asmi, Faten; Brantis-de-Carvalho, Carlos E.; Blondel, Danielle; Chelbi-Alix, Mounira K. 2018. "Rhabdoviruses, Antiviral Defense, and SUMO Pathway" Viruses 10, no. 12: 686.

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