Next Article in Journal
Genetic and Phenotypic Characterization of Cryphonectria hypovirus 1 from Eurasian Georgia
Next Article in Special Issue
THO Complex Subunit 7 Homolog Negatively Regulates Cellular Antiviral Response against RNA Viruses by Targeting TBK1
Previous Article in Journal
The Challenges of Analysing Highly Diverse Picobirnavirus Sequence Data
Open AccessReview

Rhabdoviruses, Antiviral Defense, and SUMO Pathway

1
INSERM UMR-S 1124, Université Paris Descartes, 75006 Paris, France
2
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS UMR 9198, Université Paris-Sud, 91190 Gif-sur-Yvette, France
*
Author to whom correspondence should be addressed.
Viruses 2018, 10(12), 686; https://doi.org/10.3390/v10120686
Received: 10 October 2018 / Revised: 13 November 2018 / Accepted: 28 November 2018 / Published: 3 December 2018
Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (SUMO1, 2, and 3). Infection by rhabdoviruses triggers cellular responses through the activation of pattern recognition receptors, which leads to the production and secretion of interferon. This review will focus on the effects of the stable expression of the different SUMO paralogs or Ubc9 depletion on rhabdoviruses-induced interferon production and interferon signaling pathways as well as on the expression and functions of restriction factors conferring the resistance to rhabdoviruses. View Full-Text
Keywords: interferon; rabies virus; vesicular stomatitis virus; IFN; SUMO; MxA; PKR interferon; rabies virus; vesicular stomatitis virus; IFN; SUMO; MxA; PKR
Show Figures

Graphical abstract

MDPI and ACS Style

El Asmi, F.; Brantis-de-Carvalho, C.E.; Blondel, D.; Chelbi-Alix, M.K. Rhabdoviruses, Antiviral Defense, and SUMO Pathway. Viruses 2018, 10, 686.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop