Interplay Between Influenza Virus and Host Factors, 2nd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 817

Special Issue Editor


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Guest Editor
Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand
Interests: molecular virology; influenza virus; viral pathogenesis; virus–host interactions; innate antiviral response; post-translational protein modifications; protein trafficking; acetylation; HDACs; HATs
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Dear Colleagues,

The influenza virus has posed a challenge to global public health for centuries and will continue to do so for the foreseeable future due to its genetic makeup, diversity, and broad host range. The influenza virus is an obligate intracellular pathogen and interacts with numerous host factors to complete its life cycle in the host. These interactions are both exploitative and antagonistic and contribute to the host adaptation and disease severity of influenza virus. Hence, the host factors involved in the life cycle of the influenza virus may be divided into two categories—proviral and antiviral—even if some host factors might play a dual role. Influenza virus utilizes all three main parts—plasma membrane, cytoplasm, and nucleus—of a host cell to complete its life cycle. Influenza virus continues to be the subject of extensive research, and new findings on the interplay between influenza virus and host factors continue to be demonstrated. A detailed understanding of the interplay between influenza virus and host factors is key in elucidating the mechanisms of viral pathogenesis and designing targeted antiviral strategies. This Special Issue of Viruses invites articles reporting the latest research developments in this exciting area of influenza virus research.

Dr. Matloob Husain
Guest Editor

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Keywords

  • influenza virus
  • host factors
  • proviral host factors
  • antiviral host factors
  • host adaptation
  • virus entry
  • virus assembly
  • virus release
  • innate antiviral response
  • interferon-stimulated genes
  • post-translational protein modifications

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Published Papers (1 paper)

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Research

22 pages, 12280 KB  
Article
Sorting Nexin 10 Mediates Endosomal Acidification and Autophagy to Promote Influenza A Virus Infection
by Lizhu Chen, Haobin Li, Huiyi Guo, Jinlong Liang, Yingyuan Zhong, Xucheng He, Wenjiao Wu and Shuwen Liu
Viruses 2026, 18(4), 460; https://doi.org/10.3390/v18040460 - 12 Apr 2026
Viewed by 547
Abstract
The infection cycle of the Influenza A Virus (IAV) typically requires host factors to regulate replication and proliferation. However, the roles of these factors remain undiscovered. This study focuses on Sorting Nexin 10 (SNX10), which is involved in regulating membrane trafficking and endosomal [...] Read more.
The infection cycle of the Influenza A Virus (IAV) typically requires host factors to regulate replication and proliferation. However, the roles of these factors remain undiscovered. This study focuses on Sorting Nexin 10 (SNX10), which is involved in regulating membrane trafficking and endosomal stabilization. Our previous study identified that SNX10 facilitates the replication of human coronavirus OC43 through enhancing clathrin-mediated endocytosis. In our present study, we found that SNX10 significantly promoted IAV infection in host cells. The conditional knockout of Snx10 in mice lungs prolonged survival following IAV challenge. Mechanistically, SNX10 facilitated the production of acidic endosomal vesicles and promoted the accumulation of pro-viral autophagic structures, a process supported by the specific interaction between SNX10 and the viral NP and M2 protein of IAV. Blocking SNX10-mediated acidic endosomal vesicles and autophagosome formation demonstrated antiviral effects. Moreover, IAV infection increased SNX10 protein levels by suppressing its ubiquitination, suggesting that SNX10 could serve as a potential host-derived antiviral drug target. Full article
(This article belongs to the Special Issue Interplay Between Influenza Virus and Host Factors, 2nd Edition)
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