Animal Anesthesia and Analgesia Management: Pain Relief and Sedation

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: closed (15 September 2025) | Viewed by 809

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Comprehensive Health Research Centre (CHRC), Departamento de Desporto e Saúde, Escola de Saúde e Desenvolvimento Humano, Universidade de Évora, Largo dos Colegiais, 7004-516 Évora, Portugal
Interests: pain management; veterinary anesthesia; monitoring anesthetic depth; veterinary anatomy; companion animal surgery
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Special Issue Information

Dear Colleagues,

Animal anesthesia and analgesia management are important topics in the field of veterinary medicine and animal research, involving preoperative sedation, anesthesia maintenance, postoperative analgesia, and related physiological monitoring. This Special Issue aims to collate the latest research and explore anesthetic techniques, analgesic protocols, new drug applications, and their impact on animal physiology and behaviour in different animal species. At the same time, we welcome research on anesthesia safety, complication prevention, alternative therapies (such as local anesthesia, nonsteroidal anti-inflammatory drugs, multimodal analgesia), etc., to promote the scientific development of animal anesthesia and analgesia management. This Special Issue will provide veterinarians, researchers, and related practitioners with cutting-edge knowledge and practical guidance to improve animal welfare and clinical efficacy.

Dr. David Alves Ferreira Évora
Guest Editor

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Keywords

  • animal anesthesia
  • analgesia management
  • postoperative analgesia
  • sedation and analgesia
  • anesthesia monitoring
  • multimodal analgesia
  • new analgesics
  • anesthetic complications
  • animal welfare
  • local anesthesia

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Published Papers (1 paper)

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17 pages, 1443 KB  
Brief Report
Priming Canine Adipose Tissue-Derived Mesenchymal Stem Cells with CBD-Rich Cannabis Extract Modulates Neurotrophic Factors Expression Profile
by Vinicius Skau Perino, Lucas Vinícius de Oliveira Ferreira, Beatriz da Costa Kamura, Natielly Dias Chimenes, Alisson Vinícius Gimenes Olbera, Thiago Tourinho Pereira, Aline Márcia Marques Braz, Marjorie de Assis Golim, Márcio de Carvalho and Rogério Martins Amorim
Vet. Sci. 2025, 12(10), 926; https://doi.org/10.3390/vetsci12100926 - 24 Sep 2025
Viewed by 385
Abstract
The endocannabinoid system regulates key biological functions such as neuroprotection, pain modulation, inflammation, and immunomodulation. Cannabis-based therapies have gained attention due to the therapeutic potential of their bioactive compounds, particularly phytocannabinoids like cannabidiol (CBD), which exhibit anti-inflammatory, neuroprotective, and immunomodulatory properties. Mesenchymal stem [...] Read more.
The endocannabinoid system regulates key biological functions such as neuroprotection, pain modulation, inflammation, and immunomodulation. Cannabis-based therapies have gained attention due to the therapeutic potential of their bioactive compounds, particularly phytocannabinoids like cannabidiol (CBD), which exhibit anti-inflammatory, neuroprotective, and immunomodulatory properties. Mesenchymal stem cells (MSCs) are widely studied for their regenerative and immunomodulatory potential. This study evaluated the effects of priming canine adipose tissue-derived MSCs (cAT-MSCs) with a CBD-rich cannabis extract on cell morphology, viability, neurotrophic factor gene expression, and cytokine gene and protein expression. cAT-MSCs (n = 5) were primed for 24 h and divided into three groups: Control (C, unprimed), D1 (2.25 µM CBD), and D2 (225 nM CBD). No morphological or viability changes were observed. Gene expression analysis showed that groups D1 and D2 exhibited increased HGF expression. D1 also showed increased IDO and decreased BDNF expression. In contrast, no significant changes were observed in GDNF, IL-10, TNF-α, IFN-γ, or PTGES2. Regarding the cytokine profile, GM-CSF, IL-2, and IL-10 were undetectable. Notably, IL-8 and MCP-1 levels were significantly reduced in D1 compared to the control. These findings suggest that CBD priming modulates key regenerative and inflammatory mediators in cAT-MSCs, supporting its potential application in enhancing the efficacy of cell-based therapies. Full article
(This article belongs to the Special Issue Animal Anesthesia and Analgesia Management: Pain Relief and Sedation)
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