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Veterinary Sciences
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Advances in Morphology and Histopathology in Veterinary Medicine
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Advances in Morphology and Histopathology in Veterinary Medicine

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Anatomy, Histology and Pathology".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 2313

Special Issue Editors

Dr. Ilaria D'Aquino

E-Mail Website
Guest Editor
Farms and Livestock Production Hygiene Section, Local Health Authority of Benevento, 82100 Benevento, Italy
Interests: histopathology; forensic pathology; animal welfare
Special Issues, Collections and Topics in MDPI journals
Dr. Davide De Biase

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
Interests: laboratory animal medicine; myopathology; histopathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Morphology and histopathology play a fundamental role in veterinary medicine, providing critical insights into the structural and pathological changes of animal tissues across a broad spectrum of diseases. Ongoing advancements in diagnostic imaging, staining techniques, molecular pathology, and digital pathology have greatly improved the capacity to accurately evaluate tissue alterations. This Special Issue aims to highlight recent developments and applications in veterinary morphological and histopathological research. We welcome original studies, reviews, and case reports that examine structural pathology, comparative pathology, lesion characterization, and the relationships between histopathological findings and clinical outcomes in domestic, wild, or laboratory animals. By presenting cutting-edge research, this Special Issue seeks to advance disease understanding, enhance diagnostic precision, and ultimately improve animal health care in both clinical and research settings. The Guest Editors gratefully acknowledge the valuable assistance of Dr. Lorenzo Riccio (Department of Veterinary Medicine and Animal Production, University of Naples Federico II), whose expertise in specializing in clinical pathology and biochemistry has contributed significantly to the success of this Special Issue.

Dr. Ilaria D'Aquino
Dr. Davide De Biase
Guest Editors

Lorenzo Riccio
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • veterinary histopathology
  • morphological pathology
  • diagnostic techniques
  • comparative pathology
  • animal tissue analysis

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Published Papers (4 papers)

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17 pages, 1509 KB  
Article
Full Characterization of Corpus Luteum Morphological Dynamics, Echotexture, and Blood Flow During Different Stages of the Follicular Wave in Spontaneously Non-Mated Female Camels (Camelus dromedarius)
by Abdulrhman K. Alhaider, Ibrahim A. Emam and Elshymaa A. Abdelnaby
Vet. Sci. 2025, 12(12), 1212; https://doi.org/10.3390/vetsci12121212 - 18 Dec 2025
Viewed by 179
Abstract
This study was designed, for the first time, to fully characterize the corpus luteum’s (CL) dynamics, echotexture, and ovarian blood flow on the ipsilateral side of the CL during different stages of the follicular wave in spontaneously non-mated camels (Camelus dromedarius) [...] Read more.
This study was designed, for the first time, to fully characterize the corpus luteum’s (CL) dynamics, echotexture, and ovarian blood flow on the ipsilateral side of the CL during different stages of the follicular wave in spontaneously non-mated camels (Camelus dromedarius) and to correlate the CL’s size echotexture with Doppler parameters. Of 20 non-mated camels, only 7 exhibited spontaneous ovulation. B- and color-mode analyses of the CL were estimated; CL frozen image echotextures [CL echogenicity (CLE) and CL heterogeneity (CLH)] and ovarian artery (OV. A.) dynamics were recorded, and ultrasound scanning was performed. Blood sampling and progesterone (P4) levels were measured after ovulation. CL diameter and echotexture were elevated (p = 0.025 and p = 0.037) at the mid-maturation stage and compared to the early growth and late regression stages (1.03 ± 0.45/cm and 82.65 ± 2.87 for CLE and 33.65 ± 1.83 for CLH vs. 1.98 ± 0.88 cm; 66.52 ± 4.32 for CLE and 15.66 ± 0.25 for CLH vs. 1.02 ± 0.02 cm, 65.12 ± 2.66 for CLE, and 19.32 ± 1.33 for CLH), as those parameters are critical in the determination of CL activity. Ipsilateral OV. A. diameter increased (p = 0.021) in the mid-maturation and regression stages, with a significant elevation in Doppler velocities (p = 0.025) in the maturation stage, with a decline in Doppler indices (p = 0.013), while the contralateral side was not affected. Ipsilateral mean velocity (Vm; cm/s) and blood flow volume (BFV; mL/min) were increased in the mid-maturation stage (23.55 ± 0.66 cm/s and 25.62 ± 0.32 mL/min). CL diameter was positively correlated with the CL’s total colored area/pixels (r = 0.81; p = 0.001), total colored area % (r = 0.93; p = 0.001), and OV. A. velocities (r = 0.96; p = 0.001). In addition, there was a positive correlation between CLH and OV. A.BFV (r = 0.89; p = 0.001). After spontaneous ovulation, the CL increases in diameter and reaches its peak on day 12, with an elevation in the P4 level at day 10, and the total colored area of the CL continues to elevate until day 14. Ipsilateral OV. A. blood flow is elevated and linked to changes that occur in the CL’s total coloration %. Evaluating luteal function in camels presents several challenges due to the species’ unique reproductive physiology. Full article
(This article belongs to the Special Issue Advances in Morphology and Histopathology in Veterinary Medicine)
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11 pages, 2238 KB  
Article
Evaluation of Pancreatic Endocrine Reprogramming in Diabetic Cats
by Lune D. Geurts, Alice Zanon, Eylem E. Akyurek, Silvia Ferro, Roberta Sacchetto, Mila Della Barbera, Carolina Callegari, Gabriele Gerardi, Federico Fracassi, Hans S. Kooistra, Thomas A. Lutz and Eric Zini
Vet. Sci. 2025, 12(12), 1167; https://doi.org/10.3390/vetsci12121167 - 8 Dec 2025
Viewed by 225
Abstract
Transcription factors control the development of the endocrine pancreas in various mammals. In humans, paired box-4 (PAX4) and aristaless-related homeobox (ARX) allocate endocrine progenitor cells toward β-cell and α-cell specification, respectively. In adulthood, PAX4 contributes to reprogramming α-cells into β-cells and exocrine into [...] Read more.
Transcription factors control the development of the endocrine pancreas in various mammals. In humans, paired box-4 (PAX4) and aristaless-related homeobox (ARX) allocate endocrine progenitor cells toward β-cell and α-cell specification, respectively. In adulthood, PAX4 contributes to reprogramming α-cells into β-cells and exocrine into endocrine cells; induction of ARX in β-cells drives them to reprogram into α-cells. Feline diabetes mellitus has a similar pathophysiology to human type 2 diabetes, but information about the role of these transcription factors is unavailable in diabetic cats. The study aim was to test whether diabetic cats have an increased number of pancreatic cells expressing developmental markers of β- and α-cells, respectively, suggesting reprogramming. In 9 diabetic and 9 well-matched control cats, pancreas was collected, formalin-fixed and paraffin-embedded. Tissue slides were labelled for insulin, glucagon, PAX4, and ARX. Positive cells for each marker and double-positive cells for their combinations were counted in the pancreas and compared between groups. Against controls, diabetic cats had fewer insulin-positive cells in the islets (p = 0.001) and exocrine pancreas (p = 0.038); glucagon-positive cells were similar. In the islets, diabetic cats had higher counts of insulin/glucagon-positive cells (p = 0.024), PAX4-positive cells (p = 0.038), as well as PAX4/insulin-positive cells (p = 0.027). In conclusion, in diabetic cats, the increased number of islet cells expressing PAX4 leads to the hypothesis that β-cells change to an earlier stage of differentiation or that novel β-cells are formed. Furthermore, the higher count of islet insulin/glucagon-positive cells might indicate that α-cells transform into β-cells or vice versa. Hence, reprogramming seems possible in diabetic cats, specifically in the islets. Full article
(This article belongs to the Special Issue Advances in Morphology and Histopathology in Veterinary Medicine)
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14 pages, 2985 KB  
Article
Effectiveness of Custom-Designed 3D-Printed Drill Guides in the Treatment of Lateral Humeral Condylar Fractures in a French Bulldog Bone Model
by Jirawat Srikusalanukul, Nattapon Chantarapanich and Chaiyakorn Thitiyanaporn
Vet. Sci. 2025, 12(9), 888; https://doi.org/10.3390/vetsci12090888 - 14 Sep 2025
Viewed by 960
Abstract
The French Bulldog is a breed predisposed to lateral humeral intercondylar fractures. A transcondylar lag screw combined with an epicondylar pin is most commonly used for their repair. However, improper screw and pin placement is common. This study used a 3D-printed plastic bone [...] Read more.
The French Bulldog is a breed predisposed to lateral humeral intercondylar fractures. A transcondylar lag screw combined with an epicondylar pin is most commonly used for their repair. However, improper screw and pin placement is common. This study used a 3D-printed plastic bone model, designed from a 5-year-old 19.5 kg French Bulldog’s humerus. Then, a 3D-printed drill guide was designed specifically for a lateral humeral condylar fracture. The bone models were divided into two groups: the first group included the use of the 3D-printed drill guide during the screw and pin placement, and the second group did not. After implantation, we compared the angle deviation of the transcondylar screw and the epicondylar pin, as well as the exit point translation of the transcondylar screw. The results showed differences between the two groups. The first group exhibited a lower angle deviation than the second group. Additionally, the exit point translation of the transcondylar screw was reduced in the drill guide group. The use of a custom-designed 3D-printed drill guide significantly improved the accuracy of the transcondylar screw and epicondylar pin placement. This advancement could reduce the incidence of postoperative complications. Full article
(This article belongs to the Special Issue Advances in Morphology and Histopathology in Veterinary Medicine)
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7 pages, 2009 KB  
Brief Report
Bronchioloalveolar Carcinoma in a Striped Dolphin (Stenella coeruleoalba) Stranded on Thyrrhenian Sea Coast
by Maria Dimatteo, Maria Oliviero, Marianna D’amore, Luigia Contaldo, Giuseppe Lucifora, Stefania Giglio, Giovanna Fusco and Barbara degli Uberti
Vet. Sci. 2025, 12(11), 1061; https://doi.org/10.3390/vetsci12111061 - 5 Nov 2025
Viewed by 497
Abstract
An adult male striped dolphin was found stranded on the Tyrrhenian coast of Belvedere Marittimo (Cosenza, Italy). The animal was multi-parasitized and post-mortem examination revealed a focal extensive white soft lesion with poorly defined margins on the caudal portion of the left lung. [...] Read more.
An adult male striped dolphin was found stranded on the Tyrrhenian coast of Belvedere Marittimo (Cosenza, Italy). The animal was multi-parasitized and post-mortem examination revealed a focal extensive white soft lesion with poorly defined margins on the caudal portion of the left lung. The tributary lymph node had similar multifocal lesions in the cortex and medulla. Histological analysis exhibited the presence of lung carcinoma with lymph node metastasis. Immunohistochemical examination allowed the characterization of the epithelial neoplasm as a bronchioloalveolar carcinoma. It appears to be the first case of lung cancer recorded in this species. Full article
(This article belongs to the Special Issue Advances in Morphology and Histopathology in Veterinary Medicine)
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