Impact of Maternal Nutrition on Offspring Development and Health in Ruminants

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Nutritional and Metabolic Diseases in Veterinary Medicine".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 364

Special Issue Editors


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Guest Editor
Department of Animal Science, South Dakota State University, Brookings, SD 57007, USA
Interests: beef cattle nutrition; fetal programming; nutritional physiology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA
Interests: developmental programming; blood flow; sheep

Special Issue Information

Dear Colleagues,

This Special Issue of Veterinary Sciences will focus on advancing our knowledge on the impacts of maternal mineral nutrition on offspring development and health in ruminants, including both large ruminants (e.g., cattle and buffalo) and small ruminants (e.g., sheep and goats). Maternal nutrient intake is one of the main factors that influence the availability of nutrients to the fetus, and an inadequate nutrient supply can have a long-lasting impact on offspring growth and health. Therefore, it is important to evaluate the effects of nutritional management strategies on the supply of essential nutrients delivered to the fetus. Thus, we encourage the submission of original research articles and reviews that provide novel insights into the role of nutrition during gestation and/or lactation on offspring performance and health, as well as potential epigenetic modifications.

We welcome and look forward to your contributions.

Dr. Ana Clara Baião Menezes
Dr. Manuel Vasquez-Hidalgo
Guest Editors

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Keywords

  • developmental programming
  • gestation
  • lactation
  • nutrition
  • offspring performance

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Published Papers (1 paper)

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Research

14 pages, 3345 KiB  
Article
Late Gestation Maternal Nutrition Has a Stronger Impact on Offspring Liver Transcriptome than Full-Gestation Supplementation in Beef Cattle
by Guilherme Henrique Gebim Polizel, Maria Elis Perissin dos Santos, Aline Silva Mello Cesar, Wellison J. S. Diniz, German D. Ramírez-Zamudio, Paulo Fantinato-Neto, Arícia Christofaro Fernandes, Barbara Carolina Teixeira Prati, Édison Furlan, Gabriela do Vale Pombo and Miguel Henrique de Almeida Santana
Vet. Sci. 2025, 12(5), 406; https://doi.org/10.3390/vetsci12050406 - 26 Apr 2025
Viewed by 229
Abstract
Maternal nutrition’s impact on liver transcriptome in beef cattle offspring is still underexplored. We investigated the long-term effects of maternal nutrition strategies on the liver transcriptome of pre-slaughter Nelore bulls. Pregnant cows were divided into three groups, each receiving different nutritional regimens: NP [...] Read more.
Maternal nutrition’s impact on liver transcriptome in beef cattle offspring is still underexplored. We investigated the long-term effects of maternal nutrition strategies on the liver transcriptome of pre-slaughter Nelore bulls. Pregnant cows were divided into three groups, each receiving different nutritional regimens: NP (control, only mineral supplementation), PP (late gestation protein–energy supplementation), and FP (protein–energy supplementation throughout pregnancy). Liver samples were collected from male offspring aged 22.5 ± 1 months and analyzed using RNA-Seq (n = 5 per treatment). Principal component analysis (PCA) and differential gene expression analysis were carried out in an R statistical environment. Genes were considered significant when FDR < 0.05. The over-representation analysis (ORA) was performed using the clusterProfiler package from R. Metabolic pathways were considered significant when the Q-value < 0.1. The PCA showed overlapping clusters among the groups. We identified 16 differentially expressed genes (DEGs) associated with PP × NP contrast, four with FP × NP, and two with FP × PP. The ORA revealed two significant pathways (thiamine and butanoate metabolism). The identified genes and pathways were associated with vitamins, energy, oxidative metabolism, and immune function. This study emphasizes the more significant long-term effects of the PP treatment on the offspring’s liver transcriptome compared to the FP treatment. Full article
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