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Veterinary Sciences
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Advances in Stem Cell Therapies and Regenerative Medicine in Veterinary...
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Advances in Stem Cell Therapies and Regenerative Medicine in Veterinary Sciences

A Special Issue of Veterinary Sciences (ISSN 2306-7381) belonging to the section "Veterinary Biomedical Sciences".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1316

Editors

Prof. Dr. Sun Hee Do

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Guest Editor
Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea
Interests: regenerative medicine; biomaterials; extracellular matrix; skin wound; arthritis
Prof. Dr. Soochong Kim

E-Mail Website
Guest Editor
Department of Veterinary Surgery, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Kangwon, Republic of Korea
Interests: tissue engineering; nanofiber; regenerative medicine; urinary system
Prof. Dr. Ki-hoon Kim

E-Mail Website
Guest Editor
Laboratory of Veterinary Pathology and Platelet Signaling, Department of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University, Cheongju-Si 28644, Republic of Korea
Interests: digital pathology; signal transduction; exosomes; regeneration; precision oncology

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your manuscript to this Special Issue on ‘Advances in Stem Cell Therapies and Regenerative Medicine in Veterinary Sciences.’ Stem cell-based therapies and regenerative medicine have rapidly expanded the therapeutic landscape in veterinary sciences, offering new solutions for tissue repair, functional restoration, and the management of chronic or degenerative disease. This Special Issue aims to bring together cutting-edge research that advances our understanding of stem cell biology, biomaterial-assisted regeneration and translational therapeutic approaches across animal species.

The focus of this Issue includes, but is not limited to, mesenchymal stem cells, induced pluripotent stem cells, extracellular vesicles, extracellular matrix scaffolds, and novel bioactive materials that drive regeneration in musculoskeletal, dermal, neural and internal organ systems. Studies addressing molecular mechanisms of regeneration, innovative delivery systems, comparative pathology insights and preclinical or clinical veterinary applications are particularly encouraged.

By integrating diverse regenerative strategies and diagnostic approaches, this Special Issue aims to strengthen the translational bridge between veterinary and human medicine, advancing the One Health vision. The contributions published here will expand the current literature by highlighting emerging concepts, evaluating therapeutic efficacy and presenting new perspectives to guide the next generation of regenerative therapies in veterinary practice.

Prof. Dr. Sun Hee Do
Prof. Dr. Soochong Kim
Prof. Dr. Ki-hoon Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cell therapy
  • regenerative medicine
  • tissue repair and regeneration
  • biomaterials and scaffolds
  • veterinary translational research

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

14 pages, 4908 KB  
Article
Validation of Optimal Reference Genes for qRT-PCR in Adipose- and Uterine-Derived Feline Mesenchymal Stem Cells
by Rubel Miah, Sang-Yun Lee, Su Hyeon Song, Dong-Ju Park, Yong-Ho Choe, Sung-Lim Lee, Won-Jae Lee, Chan-Hee Jo, Eun-Yeong Bok, Hyeon-Jeong Lee, Yong-Xun Jin, Yeon-Woo Jeong and Young-Bum Son
Vet. Sci. 2026, 13(9), 902; https://doi.org/10.3390/vetsci13090902 - 2 Sep 2026
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Abstract
Feline mesenchymal stem cells (MSCs) isolated from adipose (A-MSCs) and uterine (U-MSCs) tissues during routine ovariohysterectomy represent valuable therapeutic sources in veterinary regenerative medicine. While quantitative real-time PCR (qRT-PCR) remains the gold standard for transcriptional profiling in these cells, its analytical reliability relies [...] Read more.
Feline mesenchymal stem cells (MSCs) isolated from adipose (A-MSCs) and uterine (U-MSCs) tissues during routine ovariohysterectomy represent valuable therapeutic sources in veterinary regenerative medicine. While quantitative real-time PCR (qRT-PCR) remains the gold standard for transcriptional profiling in these cells, its analytical reliability relies on empirically validated reference genes. In this study, we assessed the expression stability of nine candidate reference genes (ACTB, B2M, GAPDH, GUSB, HMBS, HPRT1, RPL7, TBP, and YWHAZ) in feline A-MSCs and U-MSCs using the geNorm and NormFinder algorithms. Both computational approaches identified TBP and HMBS as the most stably expressed genes across both cell types, whereas the historically popular GAPDH was the least stable. All geNorm pairwise variation values were below the commonly used threshold of 0.15 in both A-MSCs and U-MSCs. To illustrate the impact of reference gene choice, we evaluated the pluripotency marker OCT4. Normalizing using TBP and HMBS revealed significant differences in OCT4 expression between A-MSCs and U-MSCs (p < 0.05). In contrast, applying the unstable GAPDH masked this difference. These findings identify TBP and HMBS as promising reference gene candidates for qRT-PCR normalization in P3 undifferentiated feline A-MSCs and U-MSCs. Full article
(This article belongs to the Special Issue Advances in Stem Cell Therapies and Regenerative Medicine in Veterinary Sciences)
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14 pages, 502 KB  
Article
The Biodistribution of 99mTc Labelled Equine Peripheral Blood Mesenchymal Stem Cells in Healthy and Chronic Gingivostomatitis Cats
by Charlotte Beerts, Yves Debosschere, Liesa Tack, Glenn Pauwelyn, Stephanie Carlier, Eva Depuydt, Jimmy H. Saunders, Kathelijne Peremans and Jan H. Spaas
Vet. Sci. 2026, 13(8), 727; https://doi.org/10.3390/vetsci13080727 - 23 Jul 2026
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Abstract
Feline chronic gingivostomatitis (FCGS) is a chronic inflammatory disease of the oral mucosa. Mesenchymal stem cell (MSC) treatments have been investigated as a potential treatment for this condition; however, the biodistribution profile of MSCs remains poorly understood. The goal of this study was [...] Read more.
Feline chronic gingivostomatitis (FCGS) is a chronic inflammatory disease of the oral mucosa. Mesenchymal stem cell (MSC) treatments have been investigated as a potential treatment for this condition; however, the biodistribution profile of MSCs remains poorly understood. The goal of this study was to assess the relative pharmacokinetics of MSCs by comparing their biodistribution in healthy cats to that in cats suffering from FCGS. Two studies were performed to evaluate the biodistribution of radiolabelled equine peripheral blood-derived mesenchymal stem cells (ePB-MSCs) following intravenous and subcutaneous administration in healthy cats (n = 3) and in cats with FCGS (n = 4). Total body scintigraphic scans were obtained using a gamma camera. Free 99mTechnetium accumulation was primarily observed in the heart, lungs, stomach, bladder, thyroid, and salivary glands. Following intravenous administration of radiolabelled ePB-MSCs, increased radiopharmaceutical uptake (IRU) was mainly detected in the lungs, liver, kidneys, and bladder. After subcutaneous administration, IRU was predominantly observed at the injection site. In cats affected by FCGS, a higher radiotracer signal was observed in the rostral oral region following intravenous administration, with a mean 3.4-fold increase compared with healthy cats. The biodistribution pattern of radiolabelled ePB-MSCs differed from that of free 99mTechnetium. These findings provide preliminary information regarding the biodistribution of radiolabelled ePB-MSCs in cats. Full article
(This article belongs to the Special Issue Advances in Stem Cell Therapies and Regenerative Medicine in Veterinary Sciences)
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