Special Issue "Snakebite Envenoming: Prioritizing a Neglected Tropical Disease"
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366).
Deadline for manuscript submissions: closed (30 June 2018).
Interests: antivenom design, development and production; clinical toxinology of animal; clinical trials; first aid for snake bites; health worker training and education
Interests: evolutionary biology; herpetology; toxinology; antivenomics; snakebite; venomous bites and stings
In June 2017, the World Health Organization added snakebite envenoming to the category A list of Neglected Tropical Diseases, recognising the need to catalyse global action against this disease, which at worst estimates may claim as many as 138,000 lives and causes great suffering to between 1.8−2.7 million people around the world each year.
Renewed focus on snakebite envenoming is the result of concerted efforts by the global toxinology community, civil society and concerned nations, but advocacy alone is insufficient to bring about sustained reductions in the burden of morbidity, disability and death. There is an urgent need to develop a range of strategies and tools to capture a higher resolution understanding of the disease and how it can be effectively controlled and contained. One of the consequences of neglect is limited investment in research that can overcome the practical socioeconomic, clinical and logistical barriers to improved surveillance, diagnosis, treatment and rehabilitation.
Conventional antivenom treatment for snakebite envenoming has long been the victim of this reduced investment, and while antivenoms are often disparaged over issues of safety, stability and clinical effectiveness, fresh investment in innovation and modernisation offer great potential to extend their usefulness and save millions of lives. The same goes for emerging fields of research such as the quest for specific inhibitors of toxin activity and the development of recombinant and MAb approaches to the neutralization of snake venoms.
Many other practical problems need to be solved. How, for example, to we effectively reach out to communities and positively change their health-seeking behaviours, improve their approaches to snakebite prevention and reduce the direct and indirect socioeconomic impacts of snakebite envenoming on victims and their families? What technologies can we bring to bear to improve the reporting of snake bites in countries with fragile health systems? Despite the enormity of the problem no universal first aid intervention that could prolong life has been validated. Is this simply an impossible undertaking? What are the real costs of snakebite envenoming in different regions of the world and can we demonstrate that investment required to sustain realistic targets for control will deliver measurably greater returns in terms of these costs? How do we define effective treatment? How can we better manage snake bites that produce necrosis to reduce tissue loss and improve rehabilitation?
In this Special Issue, we will focus on where to go next in assembling an arsenal or resources, tools and strategies with which to launch a concerted effort to confront the problems standing in the way of effective snakebite control. Your contributions through reports or discussions of basic, applied and clinical research that have real potential for practical translation into real-world solutions would be very welcome.
Dr. David John Williams
Dr. Timothy Jackson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- snakebite envenoming
- health systems strengthening
- disease surveillance
- research translation