Special Issue "Advances in Diagnosis, Epidemiology and Control on Soil-Transmitted Helminth (STH) Infections"

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366).

Deadline for manuscript submissions: closed (15 May 2019).

Special Issue Editors

Guest Editor
Assoc. Prof. Dr. Bin Zhan

Section of Pediatric Tropical Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA
Website | E-Mail
Interests: helminth; soil-transmitted nematode; vaccine; parasitology; immunology; molecular biology
Guest Editor
Assoc. Prof. Dr. Ricardo J. Soares Magalhães

School of Veterinary Science, The University of Queensland, Gatton Queensland 4343, Australia
Website | E-Mail
Interests: infections disease epidemiology; spatial epidemiology; avian influenza; emerging infectious diseases; rabies; helminth infections; neglected tropical diseases; biosecurity; One Health

Special Issue Information

Dear Colleagues,

This Special Issue focuses on recent advancements in the diagnosis, epidemiology and control on soil-transmitted helminth (STH) infections.

Soil-transmitted helminth infections (STH) are the most common infections worldwide and affect more than a billion poor people around the world. The main STH species that infect people are the roundworm (Ascaris lumbricoides), the whipworm (Trichuris trichiura) and hookworms (Necator americanus and Ancylostoma duodenale). STH infections cause significant disease burden primarily in school-aged children totalling 5.2 million disability adjusted life years (DALYs).

While in some countries, during recent years, the prevalence of STH is on the decline—assisted by economic development, improved sanitary conditions and the application of mass drug administration (MDA)—there are still more than 800 million people with Ascariasis, 450 million people with each of Trichuriasis or hookworm infections. This panorama is partly because many questions with respect to the diagnosis, epidemiology and control of these infections remain unresolved.

There is a need to enhance the evidence-base for novel strategies for the effective diagnosis and control of STH infections including intervention studies into the long-term sustainability of MDA and efficacy studies of MDA regimens and delivery platforms; epidemiological investigation into socioeconomic and environmental drivers of transmission; mathematical modelling of competing strategies; epidemiology of STH benzimidazole resistance; new drug discovery; vaccine development; development of effective and accurate diagnostic methods; and finally studies into the pathophysiological mechanisms of morbidity including immunomodulation of autoimmune diseases.

Assoc. Prof. Bin Zhan
Assoc. Prof. Ricardo J. Soares Magalhães
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • • Soil-transmitted helminth (STH) infections
  • • Diagnosis
  • • Intervention trial
  • • Water and Sanitation
  • • Mass drug administration
  • Treatment efficacy
  • MDA resistance
  • Neglected tropical diseases (NTDs)
  • Epidemiology
  • Disease transmission modelling
  • Ascariasis
  • Trichuriasis
  • Hookworm infection

Published Papers (1 paper)

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Research

Open AccessArticle
High Endemicity of Soil-Transmitted Helminths in a Population Frequently Exposed to Albendazole but No Evidence of Antiparasitic Resistance
Trop. Med. Infect. Dis. 2019, 4(2), 73; https://doi.org/10.3390/tropicalmed4020073
Received: 1 April 2019 / Revised: 19 April 2019 / Accepted: 24 April 2019 / Published: 27 April 2019
PDF Full-text (611 KB) | HTML Full-text | XML Full-text
Abstract
Introduction: Soil-transmitted helminths (STHs) are gastrointestinal parasites widely distributed in tropical and subtropical areas. Mass drug administration (MDA) of benzimidazoles (BZ) is the most recommended for STH control. These drugs have demonstrated limited efficacy against Trichuris trichiura and the long-term use of single-dose [...] Read more.
Introduction: Soil-transmitted helminths (STHs) are gastrointestinal parasites widely distributed in tropical and subtropical areas. Mass drug administration (MDA) of benzimidazoles (BZ) is the most recommended for STH control. These drugs have demonstrated limited efficacy against Trichuris trichiura and the long-term use of single-dose BZ has raised concerns of the possible emergence of genetic resistance. The objective of this investigation was to determine whether genetic mutations associated with BZ resistance were present in STH species circulating in an endemic region of Honduras. Methods: A parasitological survey was performed as part of this study, the Kato–Katz technique was used to determine STH prevalence in children of La Hicaca, Honduras. A subgroup of children received anthelminthic treatment in order to recover adult parasite specimens that were analyzed through molecular biology techniques. Genetic regions containing codons 200, 198, and 167 of the β-tubulin gene of Ascaris lumbricoides and Trichuris trichiura were amplified and sequenced. Results: Stool samples were collected from 106 children. The overall STH prevalence was 75.47%, whereby T. trichiura was the most prevalent helminth (56.6%), followed by A. lumbricoides (17%), and hookworms (1.9%). Eighty-five sequences were generated for adjacent regions to codons 167, 198, and 200 of the β-tubulin gene of T. trichiura and A. lumbricoides specimens. The three codons of interest were found to be monomorphic in all the specimens. Conclusion: Although the inability to find single-nucleotide polymorphisms (SNPs) in the small sample analyzed for the present report does not exclude the possibility of their occurrence, these results suggest that, at present, Honduras’s challenges in STH control may not be related to drug resistance but to environmental conditions and/or host factors permitting reinfections. Full article
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