MRSA (Methicillin-Resistant Staphylococcus aureus) Immunotherapies
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366).
Deadline for manuscript submissions: 31 December 2026 | Viewed by 119
Editor
Interests: MRSA; penicillin-binding proteins; PBP2a; mecA gene; serum therapy; vaccines; monoclonal antibodies and immunodiagnostics
Special Issue Information
Dear Colleagues,
Multidrug-resistant (MDR) bacteria remain a major global health concern, with Methicillin-resistant Staphylococcus aureus (MRSA) classified as a high-priority pathogen by the World Health Organization (2024).
PBP2a (penicillin-binding protein 2a), encoded by the mecA gene, is a unique feature of these bacteria. It exhibits low affinity for β-lactam antibiotics and enables continued cell wall synthesis under antimicrobial pressure.
Originally associated with S. aureus, PBP2a-mediated resistance is increasingly reported in coagulase-negative staphylococci, expanding the reservoir of resistance determinants and complicating therapeutic management.
Given the limited pipeline of novel anti-staphylococcal agents, immunologically based strategies have emerged as promising alternatives or adjuncts to antibiotic therapy. Advances in antigen discovery, structural immunology, and antibody engineering have enabled the development of candidate vaccines, therapeutic monoclonal antibodies, and antibody-derived strategies for the treatment and prevention of methicillin-resistant bacteria. In parallel, immunodiagnostic platforms exploiting antibody specificity contribute to rapid and accurate detection of methicillin-resistant strains.
This Special Issue will focus on MRSA and immunotherapeutic approaches, encompassing active immunization, passive antibody-based therapies, and immunodiagnostics.
We are pleased to invite submissions of original research, mechanistic studies, translational investigations, and critical reviews addressing immune-targeted strategies to prevent, detect, and treat methicillin-resistant staphylococcal infections.
Dr. José Procópio Moreno Senna
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- penicillin-binding proteins
- PBP2a
- MRSA
- MecA gene
- monoclonal antibodies
- vaccines
- serum therapy
- immunodiagnostic
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
