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Toxics
Special Issues
Genotoxicity of Environmental Contaminants
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Genotoxicity of Environmental Contaminants

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Novel Methods in Toxicology Research".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3574

Special Issue Editor

Prof. Dr. An Xu

E-Mail Website
Guest Editor
1. Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Chinese Academy of Sciences, Hefei 230031, China
2. Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
Interests: environmental toxicology and biological effects of static magnetic fields

Special Issue Information

Dear Colleagues,

Environmental contaminants have been closely linked to the development of various diseases and are the cause of tremendous public concern. Numerous types of contaminants, including heavy metals and organic pollutants, have been classified as Group I carcinogenic agents by the International Agency for Research on Cancer (IARC), demonstrating the important role of genotoxicity in the risk assessment of environmental contaminants. This Special Issue intends to address cutting-edge research regarding the genotoxicity of environmental contaminants. Potential topics include, but are not limited to, the genetic and epigenetic toxicity of contaminants to humans and the ecosystem and the genotoxicity and related mechanisms of emerging contaminants. We also welcome studies regarding newly developed technologies for the evaluation of the genotoxicity of  contaminants and advanced approaches in the prevention and detoxification of environmental-contaminant-induced genotoxicity.

Prof. Dr. An Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genotoxicity
  • epigenetic
  • DNA damage
  • gene mutation
  • detoxification

Published Papers (2 papers)

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Research

15 pages, 2708 KiB  
Article
The Differential Antagonistic Ability of Curcumin against Cytotoxicity and Genotoxicity Induced by Distinct Heavy Metals
by Qiao Liu, Mengzi Sun, Tong Wang, Yemian Zhou, Meng Sun, Han Li, Yun Liu and An Xu
Toxics 2023, 11(3), 233; https://doi.org/10.3390/toxics11030233 - 28 Feb 2023
Cited by 2 | Viewed by 1666
Abstract
Widespread heavy metal pollution has aroused severe health risks worldwide. Curcumin has been reported to play a wide-spectrum protective role for various heavy metals. However, the specificity and difference in the antagonistic ability of curcumin against distinct types of heavy metals are still [...] Read more.
Widespread heavy metal pollution has aroused severe health risks worldwide. Curcumin has been reported to play a wide-spectrum protective role for various heavy metals. However, the specificity and difference in the antagonistic ability of curcumin against distinct types of heavy metals are still largely unknown. Here, using cadmium (Cd), arsenic (As), lead (Pb), and nickel (Ni) as the typical heavy metals, we systematically compared the detoxification efficiency of curcumin on the cytotoxicity and genotoxicity elicited by different heavy metals under the same experimental conditions. Curcumin was proved to have a significant discrepant antagonistic capacity when counteracting the adverse effect of different heavy metals. Stronger protective effects of curcumin emerged when antagonizing the toxicity of Cd and As, rather than Pb and Ni. Curcumin exhibits a better detoxification ability against heavy metal-induced genotoxicity than cytotoxicity. Mechanistically, inhibiting the oxidative stress elicited by heavy metals and reducing the bioaccumulation of metal ions both contributed to the detoxification of curcumin against all the tested heavy metals. Our results illustrated that curcumin shows prominent detoxification specificity against different types of heavy metals and toxic endpoints, which provides a new clue for the better and targeted application of curcumin in heavy metal detoxification. Full article
(This article belongs to the Special Issue Genotoxicity of Environmental Contaminants)
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13 pages, 1193 KiB  
Article
Genotoxic Effects of Exposure to Water-Soluble Fraction of Diesel Fuel in Sand Dollar Scaphechinus mirabilis Gametes
by Victor Pavlovich Chelomin, Valentina Vladimirovna Slobodskova, Sergey Petrovich Kukla, Elena Vladimirovna Zhuravel and Andrey Pavlovich Chernyaev
Toxics 2023, 11(1), 29; https://doi.org/10.3390/toxics11010029 - 28 Dec 2022
Cited by 1 | Viewed by 1293
Abstract
Pollution of marine areas with oil and oil products is steadily growing. As part of this connection, the study of the impact of petroleum hydrocarbons on marine hydrobionts is an urgent issue of modern ecotoxicology. In our study, the genotoxic effect of the [...] Read more.
Pollution of marine areas with oil and oil products is steadily growing. As part of this connection, the study of the impact of petroleum hydrocarbons on marine hydrobionts is an urgent issue of modern ecotoxicology. In our study, the genotoxic effect of the water-soluble fraction of diesel fuel at different concentrations on the gametes of the sand dollar Scaphechinus mirabilis was evaluated. It was shown that during the incubation of sperm and eggs of a sand dollar in WAF with an oil hydrocarbon content of 1.32; 2.64; 5.37; 7.92 mg/L caused the destruction of the DNA molecule to varying degrees in both types of gametes. In addition, it has been shown that with an increase in the concentration of petroleum hydrocarbons in WAF, a large number of cells with a high level of DNA damage appear. The success of fertilization after exposure of gametes to a water-soluble extract of petroleum hydrocarbons was also evaluated. The relationship between an increase in the concentration of hydrocarbons in the tested solutions and a decrease in the level of fertilization is shown. Full article
(This article belongs to the Special Issue Genotoxicity of Environmental Contaminants)
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