Special Issue "Interactions across Different Exposures and Life-Stages in Exposome Research"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome".

Deadline for manuscript submissions: 20 May 2022.

Special Issue Editors

Prof. Dr. Soterios A. Kyrtopoulos
E-Mail Website
Guest Editor
National Hellenic Research Foundation, Institute of Chemical Biology, Vas. Constantinou 48, 11635 Athens, Greece
Interests: biomarkers; environmental genomics; DNA damage and repair; environmental toxicology; cancer epidemiology
Dr. Konstantinos C. Makris
E-Mail Website
Guest Editor
Water and Health Laboratory, Cyprus International Institute for Environmental and Public Health, School of Health Sciences, Cyprus University of Technology, Irinis 95, Limassol 3041, Cyprus
Interests: human exposome; environmental health; non-pharmacological trial; metabolomics
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Special Issue Information

Dear colleagues,

The concept of the exposome has broadened the range of exposures that must be considered for their possible role in the pathogenesis of human disease and has highlighted the importance of the effects that such exposures, occurring at different life-stages, exert in the determination of the overall risk of disease. An additional major consideration highlighted by the exposome concept concerns the way in which different exposures, whether concurrent or occurring at different life-stages, may interact and jointly modify the overall risk of disease.

Thanks to these innovative ideas, the exposome has served as a stimulus for significant advances in various areas of public and environmental health research, including exposure assessment, in utero and early-life exposures and downstream effects, as well as novel statistical tools for the analysis of highly complex datasets. On the other hand, the problem of potential interactions between the multiplicity of exposures has been less extensively studied and still represents a largely unexplored practical and theoretical challenge. The identification of such interactions in the complexity of exposures or co-exposures, often highly correlated, that are often present in high-dimensional datasets of population health, warrants the use of specialized study designs and advanced algorithms for statistical analyses. Environment-wide association studies and their exposomic tools represent novel approaches to tackle societal challenges in environmental health, toxicology, and precision medicine. For this Special Issue, we wish to invite manuscripts of all types (original studies, reviews, perspectives, etc.) that address all of the above aspects and the utility of the exposome’s methodological framework, with a particular focus on the interactions between exposures and across different life-stages.

Prof. Dr. Soterios A. Kyrtopoulos
Dr. Konstantinos C. Makris
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mixture toxicology
  • in utero exposures
  • epigenetic memory
  • delayed effects
  • early-life exposures
  • nutrient deficiencies
  • social stress
  • environment-wide association studies
  • acquired susceptibility
  • biomarkers

Published Papers (1 paper)

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Residential Green and Blue Spaces and Type 2 Diabetes Mellitus: A Population-Based Health Study in China
Toxics 2021, 9(1), 11; https://doi.org/10.3390/toxics9010011 - 16 Jan 2021
Cited by 3 | Viewed by 1026
Evidence on the health benefits of green space in residential environments is still limited, and few studies have investigated the potential association between blue space and type 2 diabetes mellitus (T2DM) prevalence. This study included 39,019 participants who had completed the baseline survey [...] Read more.
Evidence on the health benefits of green space in residential environments is still limited, and few studies have investigated the potential association between blue space and type 2 diabetes mellitus (T2DM) prevalence. This study included 39,019 participants who had completed the baseline survey from the Henan Rural Cohort Study, 2015–2017. The Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI) were employed to characterize the residential green space, and the distance from the participant’s residential address to the nearest water body was considered to represent the residential blue space. Mixed effect models were applied to evaluate the associations of the residential environment with T2DM and fasting blood glucose (FBG) levels. An interquartile range (IQR) increase in NDVI and EVI was significantly associated with a 13.4% (odds ratio (OR): 0.866, 95% Confidence interval (CI): 0.830,0.903) and 14.2% (OR: 0.858, 95% CI: 0.817,0.901) decreased risk of T2DM, respectively. The residential green space was associated with lower fasting blood glucose levels in men (%change, −2.060 in men vs. −0.972 in women) and the elderly (%change, −1.696 in elderly vs. −1.268 in young people). Additionally, people who lived more than 5 km from the water body had a 15.7% lower risk of T2DM (OR: 0.843, 95% CI: 0.770,0.923) and 1.829% lower fasting blood glucose levels (95% CI: −2.335%,−1.320%) than those who lived closer to the blue space. Our findings suggest that residential green space was beneficially associated with T2DM and fasting blood glucose levels. However, further research is needed to explore more comprehensively the relationship between residential blue space and public health. Full article
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