Insights into Toxicological Effects of Micro- and Nano-Plastics

A special issue of Toxics (ISSN 2305-6304).

Deadline for manuscript submissions: 10 March 2026 | Viewed by 2171

Special Issue Editor


E-Mail Website
Guest Editor
Institute of Public Health, University of South China, Hengyang 421001, China
Interests: nanotoxicology; cardiovascular effects; 3D human brain organoids; zebrafish; Kruppel-like factors; neurotoxicology

Special Issue Information

Dear Colleagues,

Due to the wide uses of plastics, micro- and nano-plastics (MNPs) have become emerging environmental pollutants and hold broad research interests for their potential toxicity to humans. MNPs can originate directly from industrial production as primary particles, or may form by the degradation of larger plastics into secondary particles. The toxicity of MNPs is influenced by many factors, such as concentrations, exposure durations, particle sizes, their interactions with other molecules, and the models used for evaluation. This Special Issue will share the latest developments in the understanding of MNPs’ toxicity and mechanisms. The potential topics may include, but are not limited to, the following: (1) prediction of the acute and chronic toxicity of MNPs; (2) investigation of the toxicological mechanisms of MNPs, such as oxidative stress, autophagy and/or endoplasmic reticulum stress, and microflora dysbiosis; (3) evaluation of the current models to study MNPs’ toxicity, including cell cultures, model organisms, alternative models, and computational models—combining multiple models for better prediction of human risk is highly encouraged; (4) how the interactions between MNPs and other molecules, such as nutrient molecules in vivo, impact the biological effects of MNPs; (5) investigation of the role of particle size in determining the toxicological effects of MNPs. Both original articles and review/perspectives that reflect the latest developments in this field are welcome.

Prof. Dr. Yi Cao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro- and nano-plastics (MNPs)
  • acute toxicity
  • chronic toxicity
  • alternative models
  • toxicological mechanisms
  • MNP and nutrient molecule interactions
  • size-dependent effects

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

31 pages, 1084 KB  
Review
Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects
by Antonio F. Hernández, Marina Lacasaña, Aristidis M. Tsatsakis and Anca Oana Docea
Toxics 2025, 13(11), 921; https://doi.org/10.3390/toxics13110921 - 28 Oct 2025
Cited by 1 | Viewed by 1719
Abstract
Micro- and nanoplastics (MNPs) are increasingly recognized as emerging contaminants of concern for human health. Their small size, diverse composition, and reactive surface enable interactions with biological barriers and cellular systems. This comprehensive narrative review synthesizes and critically evaluates current evidence on the [...] Read more.
Micro- and nanoplastics (MNPs) are increasingly recognized as emerging contaminants of concern for human health. Their small size, diverse composition, and reactive surface enable interactions with biological barriers and cellular systems. This comprehensive narrative review synthesizes and critically evaluates current evidence on the mechanistic effects of MNPs in humans and experimental models. Systemic mechanisms, including oxidative stress, inflammation, barrier disruption, and immune dysregulation, may underlie reported adverse effects in the gastrointestinal tract, cardiovascular, nervous and reproductive systems, as well as the placenta. Omics studies further reveal alterations in metabolic and stress-response pathways, providing systems-level insights and candidate biomarkers. Human data remain limited to biomonitoring studies, and causality has not yet been established. Toxicological data, though informative, often rely on pristine particles and high-dose, short-term exposures that exceed environmental estimates, highlighting the need for chronic, low-dose models. Major challenges include difficulties in detecting and quantifying MNPs in tissues, limited attribution of effects to polymers versus additives or adsorbed contaminants, and lack of standardized characterization and reporting. Emerging advances, such as reference materials, omics profiling, and organ-on-chip technologies, offer opportunities to close these gaps. Overall, the available data suggest biologically plausible pathways for health risks, but methodological refinement and harmonized research strategies are essential for robust human health assessment. Full article
(This article belongs to the Special Issue Insights into Toxicological Effects of Micro- and Nano-Plastics)
Show Figures

Graphical abstract

Back to TopTop