Environment Chemical Pollutant Exposure and Immunotoxicology

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1740

Special Issue Editors


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Guest Editor
Health Science Center, Peking University, Beijing, China
Interests: immunotoxicology; molecular and cellular toxicology; environmental pollution; pharmaceutical toxicology; immune modulation of bioactive agents

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Guest Editor
College of Public Health, Zhengzhou University, Zhengzhou, China
Interests: silicosis; immunotoxicology; macrophage; dendritic cells; epigenetics

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Guest Editor
School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China
Interests: environmental toxicology; immunotoxicity; POPs; pollutants; mode of action

Special Issue Information

Dear Colleagues,

This Special Issue, “Environment Chemical Pollutant Exposure and Immunotoxicology”, of Toxics will be mainly concentrated on the area of immunotoxicity induced by chemical pollutants, both emerging pollutants and traditional pollutants. The areas include toxicity identification, methods for evaluation, the mechanism of toxicity, and risk assessment. All the research about injury to different kinds of immunocytes, cytokines, the function of the innate immune response, and the adaptive immune response is welcome to be published in this Special Issue.

The purpose of this Special Issue is to gather all the related research in the area of immunotoxicity so as to provide plentiful information in this area at the same time. This could be convenient for scientists who pay more attention to immunotoxicology or want to browse the latest progress in the special scope focused on the injury of the immune system related to environmental contaminants.

Dr. Xuetao Wei
Prof. Dr. Changfu Hao
Dr. Wenhui Qiu
Guest Editors

Manuscript Submission Information

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Keywords

  • environmental substances
  • immunotoxicity
  • immunocyte
  • in vitro
  • in vivo
  • mechanism
  • alternative methods

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Published Papers (1 paper)

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Research

16 pages, 2340 KiB  
Article
Different Cytotoxicity Induced by Hexabromocyclododecanes on Mouse Neuroblastoma N2a Cells via Oxidative Stress and Mitochondrial Apoptotic Pathway
by Keyan Wan, Dongting Wu, Guangshan Xie, Yunxiu Li and Jianqing Zhang
Toxics 2024, 12(9), 665; https://doi.org/10.3390/toxics12090665 - 12 Sep 2024
Viewed by 1401
Abstract
Hexabromocyclododecane (HBCD) is widely used in polystyrene foams, building materials, and electrical equipment as a brominated flame retardant (BFR) and persists in the environment and human body matrix. It has attracted increased attention since its neuroendocrine disorder effects have been observed in humans [...] Read more.
Hexabromocyclododecane (HBCD) is widely used in polystyrene foams, building materials, and electrical equipment as a brominated flame retardant (BFR) and persists in the environment and human body matrix. It has attracted increased attention since its neuroendocrine disorder effects have been observed in humans and animals. However, studies evaluating the neurotoxicity of HBCD diastereoisomers and the potential mechanisms involved are still limited. In this study, we compared the cytotoxicity induced by the three HBCD diastereoisomers (i.e., α-, β-, and γ-HBCD) in N2a cells and further investigated the underlying molecular mechanism. Our results showed that HBCD diastereoisomers decreased cell viability in the order of β-HBCD > α-HBCD > γ-HBCD. Moreover, α-HBCD and β-HBCD exposure led to different degrees of cell cycle disruption and oxidative stress of N2a cells, implying that oxidative stress-mediated differential cytotoxicity of HBCD diastereoisomers. The expressions of caspases and Bcl-2 were differentially regulated by α-HBCD and β-HBCD, suggesting that the mitochondrial apoptosis pathway may be critical in HBCDs-mediated N2a cell toxicity. Therefore, our studies provided novel evidence for the underlying mechanisms of the distinct cytotoxicity of HBCD diastereoisomers. Full article
(This article belongs to the Special Issue Environment Chemical Pollutant Exposure and Immunotoxicology)
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