Toxicity and Pulmonary Effects of Particulate Matter Exposure

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Air Pollution and Health".

Deadline for manuscript submissions: closed (25 March 2025) | Viewed by 1033

Special Issue Editors

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Interests: ambient air pollution; silica particles; lung fibrosis; lung inflammation; lung function
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Guest Editor
Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, China
Interests: silicosis; asthma; benzene; hematotoxicity; immunotoxicology; respiratory toxicology

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Guest Editor
Department of Toxicology, School of Public Health, Xinjiang Medical University, Xinjiang 830011, China
Interests: particulate matter; respiratory toxicology; environmental pollution

Special Issue Information

Dear Colleagues,

The presence of particulate matter in the atmosphere is a significant environmental and public health issue worldwide. Once particulate matter is released into the air, whether from industrial processes, vehicle emissions, or natural sources, it can be inhaled and interact with the respiratory system, potentially leading to severe health consequences across various population groups. Therefore, there is an urgent need to deepen our understanding of the effects of particulate matter exposure on pulmonary health so we can better estimate and mitigate its impact.

This Special Issue will focus on the latest research concerning the toxicity and pulmonary effects of particulate matter exposure. Topics may include, but are not limited to, the investigation of the sources and characteristics of particulate matter, including fine and ultrafine particles; the toxicological mechanisms through which particulate matter affects lung tissues and respiratory function; epidemiological studies linking particulate matter exposure to respiratory diseases such as asthma, COPD, lung cancer, etc.; the clinical implications of particulate matter exposure and its impact on public health. We invite submissions of original research papers, reviews, and short communications that advance our knowledge in these areas.

Dr. Jixuan Ma
Dr. Qiang Jia
Dr. Deqi Su
Guest Editors

Manuscript Submission Information

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Keywords

  • particulate matter
  • silica particles
  • lung fibrosis
  • lung inflammation
  • environmental pollution
  • respiratory toxicology

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Published Papers (1 paper)

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Research

8 pages, 747 KiB  
Communication
Biomass Smoke Exposure Reduces DNA Methylation Levels in PRSS23 (cg23771366) in Women with Chronic Obstructive Pulmonary Disease
by Gloria Pérez-Rubio, Ramcés Falfán-Valencia, Omar Andrés Bravo-Gutiérrez, Nancy Lozano-González, Alejandra Ramírez-Venegas, Filiberto Cruz-Vicente and María Elena Ramírez-Díaz
Toxics 2025, 13(4), 253; https://doi.org/10.3390/toxics13040253 - 28 Mar 2025
Viewed by 786
Abstract
COPD induced by biomass-burning smoke is a public health problem in developing countries. Biomass-based fuels are ineffective and deliver elevated levels of carbon monoxide, polycyclic aromatic hydrocarbons, and fine particulate matter. PRSS23 participates in extracellular matrix remodeling processes in COPD patients. Our objective [...] Read more.
COPD induced by biomass-burning smoke is a public health problem in developing countries. Biomass-based fuels are ineffective and deliver elevated levels of carbon monoxide, polycyclic aromatic hydrocarbons, and fine particulate matter. PRSS23 participates in extracellular matrix remodeling processes in COPD patients. Our objective was to estimate the DNA methylation levels of cg23771366 (PRSS23) and their clinical relevance in COPD caused by chronic exposure to biomass-burning smoke (BBS). We included 80 women with COPD (COPD-BBS) (≥200 h per year), 180 women with exposure to BBS (≥200 h per year) but without COPD (BBES), and 79 lung-healthy women (HW) without exposure to biomass-burning smoke. The DNA methylation analysis shows significant differences between the three groups included in this study (p < 0.001). HW had high methylation levels (100%) in cg23771366 (PRSS23). In comparison, COPD-BBS and BBES had low levels [0.91% vs. 9.17%, respectively], showing statistically significant differences (p = 0.011) between both groups, with the COPD-BBS presenting the lowest levels in the methylation of cg23771366. In conclusion, chronic biomass-burning smoke exposure is associated with decreased levels of DNA methylation at the CpG cg23771366 site in PRSS23, reinforcing the relationship between PRSS23 and particulate matter. Full article
(This article belongs to the Special Issue Toxicity and Pulmonary Effects of Particulate Matter Exposure)
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