Novel Insights into Liver Transplantation Surgery

A special issue of Surgeries (ISSN 2673-4095).

Deadline for manuscript submissions: closed (31 July 2026) | Viewed by 1408

Editors


E-Mail Website
Guest Editor
Division of Transplant Surgery, Department of Surgery, The University of Oklahoma College of Medicine, Suite 8328, 800 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Interests: liver; surgery; liver transplantation

E-Mail Website
Guest Editor
Department of Surgery, Division of Solid Organ Transplant, University of Rochester Medical Center, Rochester, NY, USA
Interests: liver transplantation; liver; surgery

Special Issue Information

Dear Colleagues,

Liver transplantation is a life-saving procedure and a cornerstone of modern hepatobiliary and transplant surgery. Continuous advancements in surgical techniques, perioperative management, immunosuppression, and organ preservation have significantly improved graft survival and patient outcomes. This Special Issue, titled “Novel Insights into Liver Transplantation Surgery”, focuses on emerging surgical strategies, technological innovations, and multidisciplinary approaches that enhance outcomes and quality of life for transplant recipients.

The scope of this Special Issue includes recent developments in donor and recipient selection, advances in operative techniques, and innovations in perioperative and postoperative care. Particular emphasis is placed on living donor liver transplantation, extended-criteria donor utilization, machine perfusion technologies, and strategies to mitigate complications and improve long-term graft function.

We invite submissions that address, but are not limited to, the following topics:

  • Advances in liver transplantation surgical techniques, including living donor and split liver transplantation;
  • Innovations in organ preservation and machine perfusion technologies (normothermic and hypothermic perfusion);
  • Use of extended-criteria and marginal donors, including outcomes and risk mitigation strategies;
  • Preoperative evaluation, recipient optimization, and donor selection in liver transplantation;
  • Integration of liver transplantation with complex hepatobiliary and vascular surgical procedures;
  • Postoperative management, including immunosuppression strategies, prevention and management of complications, and long-term follow-up;
  • Role of minimally invasive and robotic approaches in donor hepatectomy and liver transplantation;
  • Ethical considerations, allocation policies, and future directions in liver transplantation.

This Special Issue aims to provide a comprehensive overview of contemporary and emerging concepts in liver transplantation surgery, emphasizing innovative approaches that improve graft survival, reduce complications, and enhance long-term patient outcomes and quality of life.

Dr. Maheswaran Pitchaimuthu
Dr. Amit Nair
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Surgeries is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver transplantation
  • organ preservation
  • machine perfusion technologies
  • preoperative evaluation
  • recipient optimization
  • donor selection
  • postoperative management
  • surgical techniques

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Published Papers (1 paper)

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Research

11 pages, 669 KB  
Article
Direct Antiviral Agents May Obviate the Need for Liver Transplantation for HCV Cirrhosis by the End of the Decade
by Nathanael Haynes, Allyson Cochran, Maria Baimas-George, William Archie, Namratha Mylarapu, Vincent Casingal, Jose Soto, Philippe Zamor, Andrew DeLemos, Paul Schmeltzer, Steven Zacks, Natasha Adlakha, Roger Denny, Mark Russo, Lon Eskind and Dionisios Vrochides
Surgeries 2026, 7(2), 51; https://doi.org/10.3390/surgeries7020051 - 23 Apr 2026
Viewed by 916
Abstract
Background: Hepatitis C viral infection (HCV) has historically been a leading indication for liver transplantation (LTx), primarily due to its progression to cirrhosis and hepatocellular carcinoma (HCC). However, the advent of direct-acting antiviral agents (DAAs) over a decade ago has revolutionized HCV treatment, [...] Read more.
Background: Hepatitis C viral infection (HCV) has historically been a leading indication for liver transplantation (LTx), primarily due to its progression to cirrhosis and hepatocellular carcinoma (HCC). However, the advent of direct-acting antiviral agents (DAAs) over a decade ago has revolutionized HCV treatment, achieving sustained virologic response (SVR) in over 90% of patients and potentially altering LTx indications. Aim: To investigate the impact of DAAs on HCV-related indications, with or without HCC, and model future trends in LTx indications. Methods: We retrospectively reviewed 1504 liver transplants performed between 2000 and 2024 at a single center. Patients were categorized into three cohorts: HCV-only, HCC-only, and HCC with HCV co-infection (HCC/HCV). Relative transplant volumes by-year, post-operative outcomes, and HCC recurrence rates were analyzed across pre- and post-DAA eras. ARIMA modeling was employed to project trends in transplant indications through the year 2030. Results: The proportion of transplants for HCV alone declined by 82.3% from 2015 to 2020, while HCC/HCV transplants decreased by 68.8%. Conversely, the total number of transplants for HCC alone increased during this period, with a modest proportional decrease of 8.3% from 2015 to 2020. ARIMA modeling suggests that by 2030, LTxs for HCV alone may be nearly eliminated. The projected proportion of transplants conducted for HCC alone remains the highest of all three study indications at 4.3%. Conclusions: DAAs have reduced LTx due to HCV. By 2030, LTx for HCV-related cirrhosis, particularly without HCC, may be obviated. This underscores the need to reevaluate allocation for emerging oncologic indications. Full article
(This article belongs to the Special Issue Novel Insights into Liver Transplantation Surgery)
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