United Airways: Advances in the Prevention, Diagnosis, and Management of Sinusitis and Asthma

A special issue of Sinusitis (ISSN 2673-351X).

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1689

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Guest Editor
Department of Otorhinolaryngology, San Luigi Gonzaga University Hospital, Universita degli Studi di Torino, 10121 Turin, Italy
Interests: rhinosinusitis; nasal polyposis; endoscopic sinus surgery; endoscopic septoplasty
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Special Issue Information

Dear Colleagues,

Sinusitis and asthma are highly prevalent chronic inflammatory conditions that often coexist and significantly affect patients’ quality of life. Increasing evidence supports the concept of “united airways,” in which upper and lower airway diseases share common immunological pathways, environmental triggers, and comorbidities. Understanding the interactions between rhinosinusitis and asthma is critical for improving early prevention, refining diagnostic approaches, and developing more effective treatment strategies.

This Special Issue of Sinusitis, “United Airways: Advances in the Prevention, Diagnosis, and Management of Sinusitis and Asthma”, aims to highlight recent progress in unraveling the sinusitis–asthma connection. We welcome original research, clinical studies, epidemiological investigations, and state-of-the-art reviews that explore the shared pathophysiology, diagnostic challenges, and therapeutic innovations at the interface of these two conditions. Submissions addressing immune dysfunction, allergy, infection, pollution, or systemic diseases as contributing factors are particularly encouraged. Studies on new diagnostic technologies, biologics, surgical outcomes, and precision medicine approaches are also of great interest.

By bringing together contributions from basic scientists, clinicians, and public health researchers, this Special Issue seeks to foster a deeper understanding of the united airway concept and to inform future strategies for integrated care of patients with sinusitis and asthma.

Dr. Gianluca Fadda
Guest Editor

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Keywords

  • united airways
  • sinusitis
  • asthma
  • rhinosinusitis
  • comorbidity
  • airway inflammation
  • diagnosis and management
  • precision medicine
  • biologics
  • epidemiology

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Published Papers (1 paper)

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13 pages, 1206 KB  
Systematic Review
Multifactorial Analysis of Central Compartment Atopic Disease: Atopy, Comorbid Asthma and Radiological Sinus Involvement
by Eugenio Errico, Laura Terradico, Domenica Giunta, Sveva Introini, Fabio Sovardi and Fabio Pagella
Sinusitis 2026, 10(1), 8; https://doi.org/10.3390/sinusitis10010008 - 16 Apr 2026
Viewed by 862
Abstract
Background: Central compartment atopic disease (CCAD) is a recently developed terminology used to describe a specific phenotype of chronic rhinosinusitis (CRS). The aim of this study is to provide a thorough analysis of the clinical and radiological characteristics by assessing the prevalence [...] Read more.
Background: Central compartment atopic disease (CCAD) is a recently developed terminology used to describe a specific phenotype of chronic rhinosinusitis (CRS). The aim of this study is to provide a thorough analysis of the clinical and radiological characteristics by assessing the prevalence of symptoms, asthma, allergy, aeroallergen sensitization and radiological sinus involvement. Methods: The authors searched for articles on PubMed, Cochrane, and Embase databases. A review of the articles was carried out following PRISMA guidelines; all articles were assessed for quality according to NICE criteria. Afterwards, the meta-analysis was performed with STATA 18SE software. Studies were also assessed for heterogeneity and risk of publication bias. Mean Lund-Mackay (LMK) score of patients with and without CCAD was compared. Results: A total of 16 studies were included, including 1254 patients with CRS; 537 of these were diagnosed with CCAD. The most prevalent symptoms were obstruction at 78% and congestion at 70%, followed by rhinorrhea at 66%, hyposmia at 54%, and facial pain at 24%. Dust mite at 71% was the most prevalent sensitization. Overall, the prevalence of asthma in patients with CCAD was 26%, prevalence of allergy was 67%. The mean difference in LMK scores was −3.38 in CCAD. Conclusions: Patients frequently present with nasal obstruction and congestion; the most common allergen sensitization is to dust mites. Findings on allergy and asthma prevalence support the “Unified Airway Disease” concept and emphasize the importance of a multidisciplinary approach to managing this phenotype. CCAD patients usually do not develop very high LMK scores; high scores may rule out this diagnosis. PROSPERO registration number: CRD420261361696. Full article
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