Analysis of Pharmaceuticals: Sample Preparation and Chromatography/Separation
A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Chromatographic Separations".
Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 3443
Special Issue Editor
Special Issue Information
Dear Colleagues,
The progress in the field of pharmacy and pharmaceutical analysis has reached new heights in last the two decades. The requirement of proper analytical methods is the need of the hour for the identification and estimation of pharmaceutical compounds, keeping in mind their application as well as their presence in various matrices. From a health perspective, active pharmaceutical ingredients and their metabolites and impurities need to be identified in order to achieve maximum efficiency and benefits. Regarding the environment, the presence of these APIs and their metabolites in water bodies has very deleterious effects on the metabolism of living creatures inhabiting these environments. These APIs register their presence in different environmental matrices, such as foods and water, which are supposed to be fit for human consumption. Therefore, analytical methodology for the identification, separation and quantification of APIs/biopharmaceuticals/nutraceuticals/pharmaceutically important phytochemicals and their metabolites is very much required. One of the most important steps of pharmaceutical analysis is sample preparation. If a sample is not prepared properly, it can damage the machine if it contain impurities, or the drug itself will not be identified or quantified exactly, giving erroneous results. Samples from biological matrices (e.g., blood, urine, tissues), environmental matrices (e.g., water bodies such as rivers/ponds/lakes, wastewaters), or foods like animal meats or vegetables need to be prepared in such a manner that the target molecule is free from interference from the matrix itself. There are various sample preparation techniques developed over a period of time, such as direct injection, liquid–liquid extraction and solid-phase extraction (commonly called traditional sample preparation techniques frequently exploited in pharmaceutical industries). In addition to these traditional techniques, some recently developed techniques are also currently employed for the extraction of target compounds from complex matrices, with examples including solid-phase microextraction, accelerated solvent extraction, and microwave extraction. Chemical derivatization is also gaining popularity as a sample preparation tool.
This Special Issue aims to collect recent advances, developments, and analytical innovations in sample preparation and chromatographic/separation techniques for the identification and analysis of active pharmaceutical ingredients in plant, food, and pharmaceutical products; reaction byproducts; animal feed; biological fluids (blood, urine, serum); plant and animal tissues; waste streams; or environmental samples.
Dr. Nazrul Haq
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmaceutical analysis
- food composition analysis
- biological fluids analysis
- chromatographic techniques
- liquid–liquid extraction
- solid-phase extraction
- solid-phase microextraction
- accelerated solvent extraction
- microwave extraction
- chemical derivatization
