NanoBioSensing of Extracellular Vesicles in Biofluids

Dear Colleagues,

Extracellular Vesicles are biological particles produced by eukaryotic / prokaryotic cells and present in all types of biofluids. Initially considered as cellular dust, EVs are now envisioned as one of the most promising diseases biomarkers and of major interest for therapeutical follow-up. Due to their dimension (sub-micrometer size) combined with their size distribution covering 2 orders of magnitudes and a wide range of concentration, these biological targets represent an analytical challenge that is addressed by many research groups since few years. This domain is growing rapidly and try to address also the question of the phenotyping of EVs in order to determine their cellular origin and the discrimination of their sub-populations through multiplexed bioassays.

For human diseases diagnostics, many biosensors have been developed to offer non- or minimally-invasive, highly sensitive, simple, rapid, and cost-effective solutions. Recently, promising results has been obtained in merging nanotechnology, surface chemistry, bioengineering, and different detection methods leading to nano(bio)sensors with increased performances. However, it is a real challenge to develop biosensors with such biological particles whatever different detection methods employed (electric, electrochemical, optical, piezoelectric…).

For this Special Issue, we welcome original research papers describing the development and validation of (nano)biosensors for the determination of EVs levels in any biological fluids.

This Special Issue will include wide range research articles from highly sophisticated nanosensors to analytical platforms for the characterization of targeted EVs populations in complex media. Moreover, we plan to publish a position paper that established the up-to-date prerequisites of this domain and critical review articles describing the state of the art in the above-mentioned fields.

Dr. Wilfrid Boireau
Dr. Yu-Jui Fan
Guest Editors

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• extracellular vesicles
• exosomes
• ectosomes
• microparticles
• body fluids
• nanosensors
• biosensors
• nanotechnologies