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SERS Sensors: Analytical and Biomedical Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (20 June 2022) | Viewed by 4272

Special Issue Editors


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Guest Editor
Institute of Polymers, Composites and Biomaterials (IPCB) - National Reasearch Council of Italy, Italy
Interests: Raman Spectroscopy; Biomedical applications of SERS; Diagnostic applications of Confocal Raman imagig; Infrared spectroscopy (FTIR, FT-NIR, IR microspectroscopy); Molecular Mechanics and quantum chemistry methods applied to vibrational spectroscopy

E-Mail Website
Guest Editor
Institute of Polymers, Composites and Biomaterials (IPCB) - National Reasearch Council of Italy, Rome, Italy
Interests: Raman Spectroscopy and confocal Raman imaging; SERS for molecular detection; Synthesis and characterization of SERS substrates; Infrared spectroscopy (FTIR, FT-NIR, IR microspectroscopy)

Special Issue Information

SERS sensors are gradually becoming one of the most powerful sensing platforms for specific analytical, bioanalytical, and biomedical applications. From the early days of its discovery, SERS has progressed from an narrow academic discipline to a state-of-the-art analytical tool to tackle the most demanding sensing problems. This development has been stimulated by significant advancements in spectroscopic instrumentation, nanofabrication methods, theoretical modelling, and a deeper interpretation of the vibrational behavior of interfaces. In recent years, the convergence of photonic and nanoscience technologies has led to the development of robust, compact, and inexpensive SERS systems, which are suitable for the on-field analysis of hazardous pollutants and toxic chemicals. In the biological field, applications have been proposed for glucose sensing, bacteria identification, genetic diagnostics, and immunoassay labeling.

This Special Issue is intended to summarize the latest developments in this rapidly evolving field. It is devoted to the discussion of the various applications of SERS sensing, with special emphasis on the analytical issues of the technique, such as sensitivity, reproducibility, and selectivity. Theoretically oriented arguments including but not limited to the plasmonic mechanism and the molecular interactions at interfaces are also covered.   

Dr. Pellegrino Musto
Dr. Marianna Pannico
Guest Editors

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Published Papers (1 paper)

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Research

16 pages, 2989 KiB  
Article
Efficient Capture and Raman Analysis of Circulating Tumor Cells by Nano-Undulated AgNPs-rGO Composite SERS Substrates
by Jong-Eun Park, Nuri Oh, Hyeono Nam, Ji-Ho Park, Sanha Kim, Jessie S. Jeon and Minyang Yang
Sensors 2020, 20(18), 5089; https://doi.org/10.3390/s20185089 - 7 Sep 2020
Cited by 9 | Viewed by 3840
Abstract
The analysis of circulating tumor cells (CTCs) in the peripheral blood of cancer patients is critical in clinical research for further investigation of tumor progression and metastasis. In this study, we present a novel surface-enhanced Raman scattering (SERS) substrate for the efficient capture [...] Read more.
The analysis of circulating tumor cells (CTCs) in the peripheral blood of cancer patients is critical in clinical research for further investigation of tumor progression and metastasis. In this study, we present a novel surface-enhanced Raman scattering (SERS) substrate for the efficient capture and characterization of cancer cells using silver nanoparticles-reduced graphene oxide (AgNPs-rGO) composites. A pulsed laser reduction of silver nanowire-graphene oxide (AgNW-GO) mixture films induces hot-spot formations among AgNPs and artificial biointerfaces consisting of rGOs. We also use in situ electric field-assisted fabrication methods to enhance the roughness of the SERS substrate. The AgNW-GO mixture films, well suited for the proposed process due to its inherent electrophoretic motion, is adjusted between indium tin oxide (ITO) transparent electrodes and the nano-undulated surface is generated by applying direct-current (DC) electric fields during the laser process. As a result, MCF7 breast cancer cells are efficiently captured on the AgNPs-rGO substrates, about four times higher than the AgNWs-GO films, and the captured living cells are successfully analyzed by SERS spectroscopy. Our newly designed bifunctional substrate can be applied as an effective system for the capture and characterization of CTCs. Full article
(This article belongs to the Special Issue SERS Sensors: Analytical and Biomedical Applications)
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