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Generative AI and Deep Learning for Sensor-Based Clinical Biomechanics

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Wearables".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 71

Special Issue Editor


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Guest Editor
Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy
Interests: neurology; clinical biomechanics; machine learning; movement disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Generative AI and Deep Learning are advancing sensor-based clinical biomechanics, including movement analysis, digital health, and personalized rehabilitation. AI-powered analytics are opening up new possibilities for early diagnostics, real-time patient monitoring, and precision medicine by combining data from wearable sensors, inertial measurement units (IMUs), optoelectronic motion capture systems, and force platforms.

This Special Issue focuses on the use of Generative AI, including generative adversarial networks (GANs), variational autoencoders (VAEs), and diffusion models, as well as advanced Deep Learning architectures like LSTMs, Transformers, and Graph Neural Networks (GNNs), to improve the understanding of biomechanical patterns and support neurodegenerative disease management.

We welcome contributions related to the following topics:
- Synthetic data generation for biomechanical modeling and sensor fusion;
- Deep Learning frameworks for real-time movement disorder detection and rehabilitation monitoring;
- Overcoming data scarcity with AI-driven augmentation techniques;
- Multimodal sensor integration for complete digital health applications;
- Explainable AI (XAI) enables transparent and interpretable clinical decision-making.

By bridging the gap between sensor technologies and AI-driven clinical solutions, this Special Issue hopes to attract interdisciplinary research from AI experts, clinicians, and biomechanical scientists, fostering innovation in healthcare, neuroscience, and movement science.

Dr. Mariano Serrao
Guest Editor

Dante Trabassi
Guest Editor Assistant

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Keywords

  • generative AI
  • deep learning
  • sensor-based biomechanics
  • movement analysis
  • synthetic data generation
  • wearable sensors
  • explainable AI (XAI)
  • neurodegenerative disorders

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Published Papers (1 paper)

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Research

24 pages, 1377 KiB  
Article
Impact of Temporal Resolution on Autocorrelative Features of Cerebral Physiology from Invasive and Non-Invasive Sensors in Acute Traumatic Neural Injury: Insights from the CAHR-TBI Cohort
by Nuray Vakitbilir, Rahul Raj, Donald E. G. Griesdale, Mypinder Sekhon, Francis Bernard, Clare Gallagher, Eric P. Thelin, Logan Froese, Kevin Y. Stein, Andreas H. Kramer, Marcel J. H. Aries and Frederick A. Zeiler
Sensors 2025, 25(9), 2762; https://doi.org/10.3390/s25092762 - 27 Apr 2025
Viewed by 68
Abstract
Therapeutic management during the acute phase of traumatic brain injury (TBI) relies on continuous multimodal cerebral physiologic monitoring to detect and prevent secondary injury. These high-resolution data streams come from various invasive/non-invasive sensor technologies and challenge clinicians, as they are difficult to integrate [...] Read more.
Therapeutic management during the acute phase of traumatic brain injury (TBI) relies on continuous multimodal cerebral physiologic monitoring to detect and prevent secondary injury. These high-resolution data streams come from various invasive/non-invasive sensor technologies and challenge clinicians, as they are difficult to integrate into management algorithms and prognostic models. Data reduction techniques, like moving average filters, simplify data but may fail to address statistical autocorrelation and could introduce new properties, affecting model utility and interpretation. This study uses the CAnadian High-Resolution TBI (CAHR-TBI) dataset to examine the impact of temporal resolution changes (1 min to 24 h) on autoregressive integrated moving average (ARIMA) modeling for raw and derived cerebral physiologic signals. Stationarity tests indicated that the majority of the signals required first-order differencing to address persistent trends. A grid search identified optimal ARIMA parameters (p,d,q) for each signal and resolution. Subgroup analyses revealed population-specific differences in temporal structure, and small-scale forecasting using optimal parameters confirmed model adequacy. Variations in optimal structures across signals and patients highlight the importance of tailoring ARIMA models for precise interpretation and performance. Findings show that both raw and derived indices exhibit intrinsic ARIMA components regardless of resolution. Ignoring these features risks compromising the significance of models developed from such data. This underscores the need for careful resolution considerations in temporal modeling for TBI care. Full article
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