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Optical Imaging for Medical Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensing and Imaging".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 1320

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Guest Editor
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310007, China
Interests: biomedical imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Optical imaging techniques have become indispensable in the biomedical field, offering a broad spectrum of applications across disciplines such as oncology, neuroscience, cardiology, physiology, and biomaterials. These techniques provide diverse optical contrasts, unveiling critical biological information ranging from anatomical structures to functional and molecular characteristics. As a result, they are vital tools for both preclinical research and clinical practice.

In light of the significant advancements in optical imaging technologies in recent years, we are excited to announce a Special Issue focused on pioneering developments in optical imaging for biomedicine. This issue will highlight recent innovations and emerging trends in optical imaging devices, their biomedical applications, methodological advancements, and interdisciplinary research that leverages these technologies. We invite research teams worldwide to submit original research articles, reviews, and short communications to contribute to this Special Issue of Sensors.

Dr. Li Lin
Guest Editor

Manuscript Submission Information

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Keywords

  • fluorescence imaging
  • photoacoustic imaging
  • optical coherence tomography
  • diffuse optical tomography
  • Raman spectroscopy
  • multiphoton fluorescence microscopy
  • confocal microscopy
  • light sheet microscopy
  • light field microscopy
  • super-resolution microscopy

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Published Papers (2 papers)

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Research

9 pages, 1583 KiB  
Article
Snapshot Quantitative Phase Imaging with Acousto-Optic Chromatic Aberration Control
by Christos Alexandropoulos, Laura Rodríguez-Suñé and Martí Duocastella
Sensors 2025, 25(14), 4503; https://doi.org/10.3390/s25144503 - 20 Jul 2025
Viewed by 114
Abstract
The transport of intensity equation enables quantitative phase imaging from only two axially displaced intensity images, facilitating the characterization of low-contrast samples like cells and microorganisms. However, the rapid selection of the correct defocused planes, crucial for real-time phase imaging of dynamic events, [...] Read more.
The transport of intensity equation enables quantitative phase imaging from only two axially displaced intensity images, facilitating the characterization of low-contrast samples like cells and microorganisms. However, the rapid selection of the correct defocused planes, crucial for real-time phase imaging of dynamic events, remains challenging. Additionally, the different images are normally acquired sequentially, further limiting phase-reconstruction speed. Here, we report on a system that addresses these issues and enables user-tuned defocusing with snapshot phase retrieval. Our approach is based on combining multi-color pulsed illumination with acousto-optic defocusing for microsecond-scale chromatic aberration control. By illuminating each plane with a different color and using a color camera, the information to reconstruct a phase map can be gathered in a single acquisition. We detail the fundamentals of our method, characterize its performance, and demonstrate live phase imaging of a freely moving microorganism at speeds of 150 phase reconstructions per second, limited only by the camera’s frame rate. Full article
(This article belongs to the Special Issue Optical Imaging for Medical Applications)
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17 pages, 6114 KiB  
Article
Application of Wood’s Lamp in Dermatological and Dental Photodiagnostics
by Mirosław Kwaśny, Paulina Stachnio and Aneta Bombalska
Sensors 2025, 25(11), 3253; https://doi.org/10.3390/s25113253 - 22 May 2025
Viewed by 894
Abstract
This article provides an overview of the possibilities of using a modern Wood’s lamp in dermatological diagnostics. In the experimental part, this study examined the possibilities of the light source in photodiagnostics combined with the photodynamic method (PDT) and determined the lower detection [...] Read more.
This article provides an overview of the possibilities of using a modern Wood’s lamp in dermatological diagnostics. In the experimental part, this study examined the possibilities of the light source in photodiagnostics combined with the photodynamic method (PDT) and determined the lower detection limit of the basic photosensitizer in dermatology—protoporphyrin IX (PPIX). The absorption parameters and fluorescence quantum efficiency of PPIX were investigated, and case studies of patients in clinical conditions were presented. A new application may be the use of a Wood’s lamp in dental diagnostics to detect the early stage of caries and to monitor bacterial plaque. Fluorescence area studies were conducted on 21 extracted teeth with different levels of caries. The results showed that changes in enamel demineralization can be detected at a level as low as a 5–10% decrease in fluorescence. Full article
(This article belongs to the Special Issue Optical Imaging for Medical Applications)
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