Electrochemical Sensing: Technologies, Applications and Challenges
A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".
Deadline for manuscript submissions: 25 August 2026 | Viewed by 94
Special Issue Editor
Special Issue Information
Dear Colleagues,
Electrochemical sensors constitute a transformative class of analytical tools that convert chemical interactions into measurable electrical signals. These signals are detected through various architectures such as potentiometric, amperometric, voltammetric, and field-effect transistor-based systems. The design of tailored electrode interfaces plays a crucial role in achieving the sensitivity and selectivity required for a wide range of biomedical and environmental applications. By leveraging miniaturized electrodes and nanostructured surfaces, these sensors enhance signal-to-noise ratios and response times. Despite their advantages, reproducibility remains a key challenge that must be addressed for reliable implementation. Among the different types, amperometric sensors, known for measuring current generated by redox reactions at electrode surfaces, have emerged as the very standard in enzymatic biosensing, as evidenced by their widespread use in commercial monitoring strips. These sensors effectively translate biochemical signals into quantifiable electrical outputs using conventional electronic systems. Potentiometric devices, typically ion-selective electrodes, are essential for monitoring electrolyte concentrations and pH levels, particularly in clinical diagnostics. Voltammetric techniques, on the other hand, offer robust analytical capabilities and enable multi-analyte discrimination, though they demand more sophisticated instrumentation for consistent signal acquisition.
Recent advancements in electrochemical sensing have led to the integration of miniaturized electrodes and microfabricated arrays, facilitating rapid data acquisition in small sample volumes and complex in situ environments. However, achieving high selectivity in physiologically complex matrices remains critical for accurate in vivo and wearable applications, especially under electrocatalytic conditions. In biomedical applications, electrochemical sensors are increasingly used in wearable technologies, point-of-care diagnostics, and clinical analysis, where portability, cost-effectiveness, and direct molecular interaction are vital. Modern wearable systems now incorporate flexible electrochemical bioelectronics, including ion-selective potentiometry, enzymatic amperometry, and affinity-based sensors embedded in usual substrates, allowing real-time monitoring of biomarkers in sweat and interstitial fluids.
This Special Issue focuses on new and exciting research that helps solve current problems in electrochemical sensors. It highlights creative designs for electrodes, improved materials for signal detection, and smart combinations of sensing methods. The goal is to develop advanced sensor systems that are small, multifunctional, and able to use data more effectively. By bringing together these studies, the issue hopes to encourage fresh ideas and teamwork across different fields to build the next generation of electrochemical sensors.
Dr. Shatrudhan Palsaniya
Guest Editor
Manuscript Submission Information
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Keywords
- electrochemical sensors
- biomedical devices
- low-cost electronic materials
- IoTs with sustainable routes
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