Advances in Organic Synthesis for Drug Discovery and Development
A special issue of Reactions (ISSN 2624-781X).
Deadline for manuscript submissions: 31 March 2026 | Viewed by 1932
Special Issue Editor
Interests: design and synthesis of bioactive drug candidates and prodrugs; organic synthesis; prodrug design
Special Issue Information
Dear Colleagues,
The field of drug discovery is undergoing a transformative phase, with the boundaries between traditional organic synthesis, medicinal chemistry, and chemical biology becoming increasingly fluid. This Special Issue of Reactions, "Advances in Organic Synthesis for Drug Discovery and Development", will showcase groundbreaking synthetic strategies that are revolutionizing how we design, construct, and optimize bioactive molecules. From the advent of bio-orthogonal reactions and flow chemistry to the integration of machine learning in synthetic route design, modern organic synthesis is no longer limited to bond formation—it now drives molecular innovation with precision and purpose. We are particularly interested in contributions that present novel synthetic methodologies enabling the rapid generation of chemical diversity, late-stage functionalization, and access to previously elusive pharmacophores. This Special Issue will also highlight sustainable and scalable approaches, such as catalytic and green chemistry strategies. Studies offering insights into mechanism-driven design and structure–activity relationships (SARs), especially those supported by computational or data-driven tools, are welcome. We invite researchers working at the intersection of synthesis and therapeutics to contribute original research, reviews, and communications that reflect the current and future directions of drug-focused organic synthesis.
Dr. Roberto Parise-Filho
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reactions is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- organic synthesis
- drug discovery
- molecular innovation
- catalysis
- medicinal chemistry
- sustainable chemistry
- pharmacophore design
- structure–activity relationship (SAR)
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