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Radiation
Special Issues
Biomedical Applications of Nanoscintillators
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Biomedical Applications of Nanoscintillators

A special issue of Radiation (ISSN 2673-592X).

Deadline for manuscript submissions: closed (1 June 2021) | Viewed by 4470

Special Issue Editors

Dr. Anne-Laure Bulin

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Guest Editor
Synchrotron Radiation for Biomedicine, UA07 INSERM, Université Grenoble-Alpes, European Synchrotron Radiation Facility, Biomedical Beamline, 38043 Grenoble CEDEX 9, France
Interests: nanoscintillating materials; photodynamic therapy; energy relaxation processes; radiation dose enhancement; treatment effect screening in 3D culture models
Prof. Dr. Anna Vedda

E-Mail Website
Guest Editor
Department of Materials Science, University of Milano-Bicocca, Via R. Cozzi 55, I-20125 Milano, Italy
Interests: structure-property relations of nanoscintillators; scintillating fibers for medical and high energy physics applications; scintillation process; in-vivo dosimetry; medical imaging

Special Issue Information

Dear colleagues,

Nanoscintillators are emerging nanomaterials that have rapidly gained a growing amount of interest for theranostic biomedical applications. Although scintillating materials were initially developed for the detection of ionizing radiations, nanoscintillators are currently investigated for their ability to potentiate radiation therapy via the physical radiation dose-enhancement effect, radioluminescence-induced photodynamic therapy, and the direct generation of DNA damage through the emission of UV-C radioluminescence.

In this Special Issue, we welcome submissions of high-quality research and review articles presenting investigations of biomedical applications of nanoscintillators and related content. We welcome all type of report, including in silico, in vitro and in vivo studies.

Dr. Anne-Laure Bulin
Prof. Dr. Anna Vedda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Radiation is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

13 pages, 2093 KiB  
Review
Can Cerenkov Light Really Induce an Effective Photodynamic Therapy?
by Joël Daouk, Batoul Dhaini, Jérôme Petit, Céline Frochot, Muriel Barberi-Heyob and Hervé Schohn
Radiation 2021, 1(1), 5-17; https://doi.org/10.3390/radiation1010002 - 24 Nov 2020
Cited by 10 | Viewed by 3809
Abstract
Photodynamic therapy (PDT) is a promising therapeutic strategy for cancers where surgery and radiotherapy cannot be effective. PDT relies on the photoactivation of photosensitizers, most of the time by lasers to produced reactive oxygen species and notably singlet oxygen. The major drawback of [...] Read more.
Photodynamic therapy (PDT) is a promising therapeutic strategy for cancers where surgery and radiotherapy cannot be effective. PDT relies on the photoactivation of photosensitizers, most of the time by lasers to produced reactive oxygen species and notably singlet oxygen. The major drawback of this strategy is the weak light penetration in the tissues. To overcome this issue, recent studies proposed to generate visible light in situ with radioactive isotopes emitting charged particles able to produce Cerenkov radiation. In vitro and preclinical results are appealing, but the existence of a true, lethal phototherapeutic effect is still controversial. In this article, we have reviewed previous original works dealing with Cerenkov-induced PDT (CR-PDT). Moreover, we propose a simple analytical equation resolution to demonstrate that Cerenkov light can potentially generate a photo-therapeutic effect, although most of the Cerenkov photons are emitted in the UV-B and UV-C domains. We suggest that CR-PDT and direct UV-tissue interaction act synergistically to yield the therapeutic effect observed in the literature. Moreover, adding a nanoscintillator in the photosensitizer vicinity would increase the PDT efficacy, as it will convert Cerenkov UV photons to light absorbed by the photosensitizer. Full article
(This article belongs to the Special Issue Biomedical Applications of Nanoscintillators)
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