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Proceedings

Proceedings is an open access journal dedicated to publishing findings resulting from conferences, workshops, and similar events. The conference organizers and proceedings editors are responsible for managing the peer-review process and selecting papers for conference proceedings.

Imprint Information Journal Flyer Open Access ISSN: 2504-3900

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Vol. 124

LISSSD 2025

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Vol. 123

Symmetry 2025

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Vol. 120

COL4A1-A2

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Vol. 118

CORAF 2023

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Vol. 117

HAICTA 2024

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Vol. 115

12th CNN Workshop

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Latest Articles

2 pages, 123 KB

Open AccessAbstract

Check4Strep: A Community-Based Pilot Project to Understand and Respond to Infection with Group A Streptococcus

by Olivia Walsh, Vicki Wade, Rachel Burgess, Valerina Mungatopi, Patrick Grant, Segora Babui, Ella Meumann, Bianca Middleton, Mark Davies, Asha Bowen, Rosemary Wyber and Anna Ralph

Proceedings 2025, 124(1), 23; https://doi.org/10.3390/proceedings2025124023 - 26 Aug 2025

Background: ‘Check4Strep’ is a community-based, participatory action research (PAR) pilot study in a remote northern territory community [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

9 pages, 1005 KB

Open AccessProceeding Paper

General Theory of Information and Mindful Machines

by Rao Mikkilineni

Proceedings 2025, 126(1), 3; https://doi.org/10.3390/proceedings2025126003 - 26 Aug 2025

As artificial intelligence advances toward unprecedented capabilities, society faces a choice between two trajectories. One continues scaling transformer-based architectures, such as state-of-the-art large language models (LLMs) like GPT-4, Claude, and Gemini, aiming for broad generalization and emergent capabilities. This approach has produced powerful [...] Read more.

As artificial intelligence advances toward unprecedented capabilities, society faces a choice between two trajectories. One continues scaling transformer-based architectures, such as state-of-the-art large language models (LLMs) like GPT-4, Claude, and Gemini, aiming for broad generalization and emergent capabilities. This approach has produced powerful tools but remains largely statistical, with unclear potential to achieve hypothetical “superintelligence”—a term used here as a conceptual reference to systems that might outperform humans across most cognitive domains, though no consensus on its definition or framework currently exists. The alternative explored here is the Mindful Machines paradigm—AI systems that could, in future, integrate intelligence with semantic grounding, embedded ethical constraints, and goal-directed self-regulation. This paper outlines the Mindful Machine architecture, grounded in Mark Burgin’s General Theory of Information (GTI), and proposes a post-Turing model of cognition that directly encodes memory, meaning, and teleological goals into the computational substrate. Two implementations are cited as proofs of concept. Full article

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2 pages, 133 KB

Open AccessAbstract

Low-Dose Interleukin-2 Therapy: A Transformative Approach for the Management of Autoimmune Complications Associated with Streptococcus pyogenes Infections

by Ailin Lepletier, Rukshan Ahamed Mohamed Rafeek, Despena Vedis, Harshi Weerakoon, Natkunam Ketheesan, Michael F. Good and Manisha Pandey

Proceedings 2025, 124(1), 21; https://doi.org/10.3390/proceedings2025124021 - 22 Aug 2025

Acute rheumatic fever is an autoimmune inflammatory reaction to Streptococcus pyogenes infections, leading to progressive heart valve damage and rheumatic heart disease (RHD) [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 133 KB

Open AccessAbstract

Genomic Surveillance of Streptococcus pneumoniae and Streptococcus pyogenes in the Czech Republic in the Post-COVID-19 Era

by Sandra Vohrnová, Renáta Veselá and Jana Kozáková

Proceedings 2025, 124(1), 20; https://doi.org/10.3390/proceedings2025124020 - 18 Aug 2025

Aim: The aim of this study is to assess the impact of COVID-19 on the incidence and molecular epidemiology of invasive infections caused by Streptococcus pneumoniae (IPD) and Streptococcus pyogenes (iGAS) in the Czech Republic (CR) [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 144 KB

Open AccessAbstract

Delineating Humoral and Cellular Immune Responses Induced by a Peptide-Based Vaccine for Protection Against Streptococcus pyogenes

by Despena Vedis, Ailin Lepletier, Victoria Ozberk, Simone Reynolds, Ainslie Calcutt, Darrell Bessette, Michael F. Good and Manisha Pandey

Proceedings 2025, 124(1), 19; https://doi.org/10.3390/proceedings2025124019 - 18 Aug 2025

Despite the substantial burden of Streptococcus pyogenes infections and their associated sequalae, there is currently no Strep A vaccine [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 136 KB

Open AccessAbstract

Human Antibodies to M-Protein Epitope-Based Vaccines Demonstrate Increased Immunogenicity and Streptococcus pyogenes (StrepA) Bactericidal Activity

by Christie T. M. Short, Vanessa Meier-Stephenson, Victoria Ozberk, Ainslie Calcutt, Simone Reynolds, Ijeoma Ogbuehi, Avi Seth, Kelly Kim, Michael Hawkes, Gregory J. Tyrrell, D. Lorne Tyrrell, Michael Houghton, Manisha Pandey and Michael F. Good

Proceedings 2025, 124(1), 18; https://doi.org/10.3390/proceedings2025124018 - 18 Aug 2025

The high antigenic diversity of Streptococcus pyogenes (StrepA) presents extensive challenges to vaccine development; however, cryptic epitopes—conserved across emm types—offer an alternative approach [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

7 pages, 171 KB

Open AccessProceeding Paper

The Evolution of Intelligence from Active Matter to Complex Intelligent Systems via Agent-Based Autopoiesis

by Gordana Dodig-Crnkovic

Proceedings 2025, 126(1), 2; https://doi.org/10.3390/proceedings2025126002 - 18 Aug 2025

Intelligence is a central topic in computing and philosophy, yet its origins and biological roots remain poorly understood. The framework proposed in this paper approaches intelligence as the complexification of agency across multiple levels of organization—from active matter to symbolic and social systems. [...] Read more.

Intelligence is a central topic in computing and philosophy, yet its origins and biological roots remain poorly understood. The framework proposed in this paper approaches intelligence as the complexification of agency across multiple levels of organization—from active matter to symbolic and social systems. Agents gradually acquire the capacity to detect differences, regulate themselves, and sustain identity within dynamic environments. Grounded in autopoiesis, cognition is reframed as a recursive, embodied process sustaining life through self-construction. Intelligence evolves as a problem-solving capacity of increasing organizational complexity: from physical self-organization to collective and reflexive capabilities. The model integrates systems theory, cybernetics, enactivism, and computational approaches into a unified info-computational perspective. Full article

2 pages, 120 KB

Open AccessAbstract

Pericardial Effusion in Acute Rheumatic Fever and Rheumatic Heart Disease

by Tehmina Kazmi, Omeir Aziz, Humera Javed, Ansar Nawaz, Ndate Fall, Craig Sable and Masood Sadiq

Proceedings 2025, 124(1), 22; https://doi.org/10.3390/proceedings2025124022 - 15 Aug 2025

Background: Pericardial effusion in ARF has been described in 5–10% of patients, but contemporary data is sparse [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 120 KB

Open AccessAbstract

GAS Regulation of Zinc Homeostasis During Skin and Soft Tissue Infection

by Reid Wilkening, Lindsey Burcham, Laura Cook and Alexander Horswill

Proceedings 2025, 124(1), 17; https://doi.org/10.3390/proceedings2025124017 - 15 Aug 2025

Streptococcus pyogenes (Group A Streptococcus, GAS) is an enigmatic human-restricted pathobiont, capable of both colonization and infection [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 133 KB

Open AccessAbstract

Incidence of Invasive Group A Streptococcal Infections and Comparison of emm Types from Carriage, Pharyngitis, and Invasive Infections in Indigenous Communities in the Southwest United States

by Catherine G. Sutcliffe, Victoria M. Sergent, Joyselynn Pitalua, Sopio Chochua, Christopher J. Gregory, Chloe Hurley, Zhongya Li, Saundra Mathis, Lesley McGee, Jennifer Onukwube Okaro, Theresa Tran, Robert Weatherholtz and Laura L. Hammitt

Proceedings 2025, 124(1), 16; https://doi.org/10.3390/proceedings2025124016 - 15 Aug 2025

Background: Indigenous communities are disproportionately affected by group A Streptococcus (GAS) infections [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 120 KB

Open AccessAbstract

Differential Immune Response in Children to Throat Specialist Versus Generalist Group A Streptococci

by Debra E. Bessen, Jeanne M. DiChiara, Freda F. Tei, Ji Ho Lee, Ari Shechtman, Shivaleela Keerthy, Suchitra Bhattacharjee, Luiza Karrer and Sang Ho Lee

Proceedings 2025, 124(1), 11; https://doi.org/10.3390/proceedings2025124011 - 15 Aug 2025

Background: The antigenic heterogeneity of GAS poses a challenge for vaccine design [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 123 KB

Open AccessAbstract

The Veituberi Approach Transforming RHD Through Patient Leadership and Lived Experience

by Erini Kala, Marika Yalimaiwai, Maria Mow, Jimaima Kailawadoko-Matanaicake and Joseph Kado

Proceedings 2025, 124(1), 14; https://doi.org/10.3390/proceedings2025124014 - 14 Aug 2025

Rheumatic heart disease (RHD), a complication of untreated Strep A infections, is a major global health concern [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 120 KB

Open AccessAbstract

Contemporary Clinical Characteristics and Presentation of ARF Globally

by Omeir Aziz, Tehmina Kazmi, Humera Javed, Ndate Fall and Masood Sadiq

Proceedings 2025, 124(1), 15; https://doi.org/10.3390/proceedings2025124015 - 13 Aug 2025

Background: Acute rheumatic fever (ARF) is a significant public health concern in resource-limited settings, but its clinical presentation remains inadequately described [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 120 KB

Open AccessAbstract

Pacific Adaptation of Tools for Implementing Rheumatic Heart Disease Control Programmes (TIPs)

by Jessica N. Daw, Rosemary Wyber and Joseph H. Kado

Proceedings 2025, 124(1), 13; https://doi.org/10.3390/proceedings2025124013 - 13 Aug 2025

In 2013, the framework ‘Tools for Implementing Rheumatic Heart Disease (RHD) Control Programmes’ (TIPs) was published [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

2 pages, 135 KB

Open AccessAbstract

Prevalence, Risk Factors, and Strain Distribution of Group A Streptococcus Carriage Among Indigenous Children in the Southwest United States

by Catherine G. Sutcliffe, Victoria M. Sergent, Joyselynn Pitalua, Sopio Chochua, Christopher J. Gregory, Chloe Hurley, Zhongya Li, Saundra Mathis, Lesley McGee, Jennifer Onukwube Okaro, Theresa Tran, Robert Weatherholtz and Laura L. Hammitt

Proceedings 2025, 124(1), 12; https://doi.org/10.3390/proceedings2025124012 - 13 Aug 2025

Background [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

9 pages, 237 KB

Open AccessProceeding Paper

Jean Piaget and Objectivity—Genetic Epistemology’s Place in a View from Nowhere

by Mark A. Winstanley

Proceedings 2025, 126(1), 1; https://doi.org/10.3390/proceedings2025126001 - 13 Aug 2025

Science pursues objectivity. According to Thomas Nagel, “we must get outside of ourselves, and view the world from nowhere within it” is the most natural expression of this goal. However, we cannot literally get outside of ourselves; realistically, we can only hope to [...] Read more.

Science pursues objectivity. According to Thomas Nagel, “we must get outside of ourselves, and view the world from nowhere within it” is the most natural expression of this goal. However, we cannot literally get outside of ourselves; realistically, we can only hope to achieve a more detached conception by relying “less and less on certain individual aspects, and more and more on something else, less individual, which is also part of us”. This “self-transcendent conception should ideally explain (1) what the world is like; (2) what we are like; (3) why the world appears to beings like us in certain respects as it is and in certain respects as it isn’t; (4) how beings like us can arrive at such a conception.” The natural and human sciences address (1)–(3), but the last condition is rarely met, according to Nagel. In this paper, I argue that the genetic epistemology conceived by Jean Piaget as a science of the growth of knowledge explains how beings like us meet condition (4). Full article

2 pages, 119 KB

Open AccessAbstract

Addressing Rheumatic Heart Disease in the Pacific

by Joseph H. Kado, Jessica N. Daw, Christine Everest and Rosemary Wyber

Proceedings 2025, 124(1), 7; https://doi.org/10.3390/proceedings2025124007 - 12 Aug 2025

Background/Purpose: Pacific leaders have articulated addressing rheumatic heart disease (RHD) as a Pacific health priority [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

8 pages, 467 KB

Open AccessProceeding Paper

Role of a Natural Antioxidant in the Secondary Shelf Life of Ready-to-Use Meat Pâté

by Beatrice Sordini, Sonia Esposto, Arianna Bonucci, Ilenia Dottori, Luigi Daidone, Stefania Urbani, Gianluca Veneziani, Roberto Selvaggini, Maurizio Servili, Davide Nucciarelli and Agnese Taticchi

Proceedings 2025, 119(1), 10; https://doi.org/10.3390/proceedings2025119010 - 11 Aug 2025

By-products from the agro-food industry can be natural ingredients for reformulating traditional foods, enhancing quality, extending secondary shelf life (SSL), and reducing food waste. This study evaluates the impact of an olive vegetation water phenolic extract (OVWPE) at two concentrations on ready-to-use meat [...] Read more.

By-products from the agro-food industry can be natural ingredients for reformulating traditional foods, enhancing quality, extending secondary shelf life (SSL), and reducing food waste. This study evaluates the impact of an olive vegetation water phenolic extract (OVWPE) at two concentrations on ready-to-use meat pâté (MP1 and MP2) under simulated retail storage. We evaluated the phenolic composition, volatile compounds, antioxidant activity, and sensory quality of the OVWPE-added pâté and compared it to the control sample (CTRL; without antioxidant). Results indicated that OVWPE minimized oxidation products, enhancing lipid stability, and also reduced the formation of C₆–C₉ aldehydes linked to rancid off-flavor. Without sensory defects, the OVWPE pâtés showed higher antioxidant activity and α-tocopherol content than the CTRL. OVWPE appears to be a promising antioxidant of natural origin for food formulations, supporting SSL extension and food waste reduction. Full article

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13 pages, 244 KB

Open AccessConference Report

Proceedings of the 13th Alcohol Hangover Research Group Meeting in Dresden, Germany

by Emina Išerić, Anne S. Boogaard, Gillian Bruce, Jacqueline M. Iversen, Analia Karadayian, Andy J. Kim, Darren Kruisselbrink, Marlou Mackus, Agnese Merlo, Ann-Kathrin Stock, Jakub Urbański, Benthe R. C. van der Weij and Joris C. Verster

Proceedings 2025, 122(1), 2; https://doi.org/10.3390/proceedings2025122002 - 11 Aug 2025

These proceedings summarize the presentations of the 13th Alcohol Hangover Research Group meeting held 20–22 April 2023 in Dresden, Germany. The purpose of this annual meeting is to discuss current research on the causes, consequences and treatment of alcohol hangover, to network, and [...] Read more.

These proceedings summarize the presentations of the 13th Alcohol Hangover Research Group meeting held 20–22 April 2023 in Dresden, Germany. The purpose of this annual meeting is to discuss current research on the causes, consequences and treatment of alcohol hangover, to network, and to establish future research collaborations. Various topics of interest were presented and discussed, including the impact of anxiety and personality on susceptibility for experiencing hangovers, sleep, the impact of the COVID-19 pandemic, the role of inflammation and alcohol metabolism in the pathology of alcohol hangover, novel treatments, and the changing regulatory landscape for hangover solutions. Full article

2 pages, 133 KB

Open AccessAbstract

Genomic Characterization and Classification of Streptococcus oralis Using Next-Generation Sequencing

by Ghiwa Chalhoub, Rayane Adam, Carmen Adam, Carni Boujanian, Rita Menhem, Peter Saba, Nancy Al Boustany, Charbel Al Khoury, Edmond Abboud, Rodrigue Saad and Sima Tokajian

Proceedings 2025, 124(1), 10; https://doi.org/10.3390/proceedings2025124010 - 8 Aug 2025

Streptococcus oralis is an alpha-hemolytic, Gram-positive bacterium from the viridans group streptococci (VGS) [...] Full article

(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))

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