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Advances in Electrospun Nanofibers for Skin Regeneration

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Fibers".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 62

Special Issue Editor


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Guest Editor
Center for Rapid and Sustainable Product Development, Polytechnic of Leiria, 2430-028 Marinha Grande, Portugal
Interests: tissue engineering; electrospinning; skin regeneration; nanofibers; biomaterials; polymers; bioresponsive structures
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Special Issue Information

Dear Colleagues,

Electrospinning is one of the most promising biofabrication techniques for skin regeneration due to its versatility. It allows the use of various polymers and biomolecules and enables the combination of different materials through multiple processing approaches, such as blending, core–shell structures, and single- or multi-jet systems. Additionally, electrospun scaffolds effectively mimic the morphology of the skin's extracellular matrix (ECM), including random fiber deposition, fiber diameter, and inter-fiber spacing.

Moreover, electrospun wound dressings have demonstrated exceptional properties, such as promoting hemostasis, absorbing exudates, ensuring permeability, conforming to wound contours, and reducing scar formation. However, despite these advantages, electrospinning presents three key limitations:

  1. Its inherently two-dimensional structure, which restricts its application in full-thickness wounds.
  2. Limited biological cues, as native ECM comprises a variety of bioactive molecules that are challenging to replicate.
  3. Poor replication of transepithelial potential, which is crucial for mimicking the "current of injury" that sustains cell migration and promotes physiological wound healing.

This Special Issue aims to provide a platform for academic exchange among researchers working on advanced structures to overcome these challenges. As Guest Editors, we invite you to submit original research or review articles on this topic.

Dr. Juliana Rosa Dias
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrospun meshes
  • skin regeneration
  • wound healing
  • 3D electrospun-based structures
  • stimuli-responsive electrospun wound dressings
  • ECM composition mimicking

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Published Papers (1 paper)

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Research

21 pages, 2443 KiB  
Article
Electrospun PEDOT-Based Meshes for Skin Regeneration
by Alexandra I. F. Alves, Nuno M. Alves and Juliana R. Dias
Polymers 2025, 17(16), 2227; https://doi.org/10.3390/polym17162227 - 15 Aug 2025
Abstract
The application of conductive polymers in wound dressings presents great potential for accelerated wound healing since their high electrical conductivity and biocompatibility facilitate the delivery of external electrical stimuli to cells and tissues, promoting cell differentiation and proliferation. Electrospinning is a very straightforward [...] Read more.
The application of conductive polymers in wound dressings presents great potential for accelerated wound healing since their high electrical conductivity and biocompatibility facilitate the delivery of external electrical stimuli to cells and tissues, promoting cell differentiation and proliferation. Electrospinning is a very straightforward method for the preparation of polymeric wound dressings capable of mimicking the extracellular matrix of skin, promoting hemostasis, absorbing wound exudate, allowing atmospheric oxygen permeation and maintaining an appropriately moist environment. In this work, in situ chemically polymerized poly(3,4-ethylenedioxythiophene) (PEDOT) was achieved through hyaluronic acid-doping. The synthesized PEDOT was used for the production of conductive and biodegradable chitosan (CS)/gelatin (GEL)/PEDOT electrospun meshes. Additionally, the randomly aligned meshes were crosslinked with a 1,4-butanediol diglycidyl ether and their physicochemical and mechanical properties were investigated. The results show that the incorporation of a conductive polymer led to an increase in conductivity of the solution, density and fiber diameter that influenced porosity, water uptake, and dissolvability and biodegradability of the meshes, while maintaining appropriate water vapor permeation values. Due to their intrinsic similarity to the extracellular matrix and cell-binding sequences, CS/GEL/PEDOT electrospun nanofibrous meshes show potential as conductive nanofibrous structures for electrostimulated wound dressings in skin tissue engineering applications. Full article
(This article belongs to the Special Issue Advances in Electrospun Nanofibers for Skin Regeneration)
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