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3D Biofabrication Technologies

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 9519

Special Issue Editors

Materials Research and Technology Department, Luxembourg Institute of Science and Technology, L-4940 Hautcharage, Luxembourg
Interests: biopolymers; additive manufacturing; biocomposites

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Guest Editor
Department of Mechanical Engineering, University of Canterbury, Christchurch 8041, New Zealand
Interests: additive manufacturing; 3D printing hydrogel; rapid product development; Design and mass manufacturing bio-based materials

Special Issue Information

Dear Colleagues,

Additive manufacturing, more commonly known as 3D printing, has been at the forefront of manufacturing research for the past few decades. There have been many advances in basic printing techniques, materials, and post-processing schemes. In recent years, there have been many critical developments in the field of 3D printing, and the convergence of additive manufacturing and printing materials is significant for the advancement of person-specific products in the pharmaceutical and medical sphere. The spectrum of materials that can be printed has also increased, allowing researchers to print a variety of materials including live cells, biopolymers, and bio-based composites. This Special Issue will deal with the main features and recent advances, as well as upcoming trends, in 3D biofabrication technologies.

Dr. Tim Huber
Dr. Hossein Najaf Zadeh
Guest Editors

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Keywords

  • 3D printing
  • bio-based composites
  • additive manufacturing

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Published Papers (2 papers)

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Research

22 pages, 7056 KiB  
Article
Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration
by Evangelos Daskalakis, Boyang Huang, Cian Vyas, Anil Ahmet Acar, Ali Fallah, Glen Cooper, Andrew Weightman, Bahattin Koc, Gordon Blunn and Paulo Bartolo
Polymers 2022, 14(3), 445; https://doi.org/10.3390/polym14030445 - 22 Jan 2022
Cited by 38 | Viewed by 6296
Abstract
The design of scaffolds with optimal biomechanical properties for load-bearing applications is an important topic of research. Most studies have addressed this problem by focusing on the material composition and not on the coupled effect between the material composition and the scaffold architecture. [...] Read more.
The design of scaffolds with optimal biomechanical properties for load-bearing applications is an important topic of research. Most studies have addressed this problem by focusing on the material composition and not on the coupled effect between the material composition and the scaffold architecture. Polymer–bioglass scaffolds have been investigated due to the excellent bioactivity properties of bioglass, which release ions that activate osteogenesis. However, material preparation methods usually require the use of organic solvents that induce surface modifications on the bioglass particles, compromising the adhesion with the polymeric material thus compromising mechanical properties. In this paper, we used a simple melt blending approach to produce polycaprolactone/bioglass pellets to construct scaffolds with pore size gradient. The results show that the addition of bioglass particles improved the mechanical properties of the scaffolds and, due to the selected architecture, all scaffolds presented mechanical properties in the cortical bone region. Moreover, the addition of bioglass indicated a positive long-term effect on the biological performance of the scaffolds. The pore size gradient also induced a cell spreading gradient. Full article
(This article belongs to the Special Issue 3D Biofabrication Technologies)
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12 pages, 4041 KiB  
Article
Effects of Raster Angle and Material Components on Mechanical Properties of Polyether-Ether-Ketone/Calcium Silicate Scaffolds
by Jibao Zheng, Enchun Dong, Jianfeng Kang, Changning Sun, Chaozong Liu, Ling Wang and Dichen Li
Polymers 2021, 13(15), 2547; https://doi.org/10.3390/polym13152547 - 31 Jul 2021
Cited by 13 | Viewed by 2551
Abstract
Polyetheretherketone (PEEK) was widely used in the fabrication of bone substitutes for its excellent chemical resistance, thermal stability and mechanical properties that were similar to those of natural bone tissue. However, the biological inertness restricted the osseointegration with surrounding bone tissue. In this [...] Read more.
Polyetheretherketone (PEEK) was widely used in the fabrication of bone substitutes for its excellent chemical resistance, thermal stability and mechanical properties that were similar to those of natural bone tissue. However, the biological inertness restricted the osseointegration with surrounding bone tissue. In this study, calcium silicate (CS) was introduced to improve the bioactivity of PEEK. The PEEK/CS composites scaffolds with CS contents in gradient were fabricated with different raster angles via fused filament fabrication (FFF). With the CS content ranging from 0 to 40% wt, the crystallinity degree (from 16% to 30%) and surface roughness (from 0.13 ± 0.04 to 0.48 ± 0.062 μm) of PEEK/CS scaffolds was enhanced. Mechanical testing showed that the compressive modulus of the PEEK/CS scaffolds could be tuned in the range of 23.3–541.5 MPa. Under the same printing raster angle, the compressive strength reached the maximum with CS content of 20% wt. The deformation process and failure modes could be adjusted by changing the raster angle. Furthermore, the mapping relationships among the modulus, strength, raster angle and CS content were derived, providing guidance for the selection of printing parameters and the control of mechanical properties. Full article
(This article belongs to the Special Issue 3D Biofabrication Technologies)
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