Nanotechnology in Antibacterial Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 1810

Special Issue Editor


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Guest Editor
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Interests: pulmonary drug delivery; bacteriophage therapy; biological antibacterials
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Special Issue Information

Dear Colleagues,

Antimicrobial resistance has been recognized as one of the top global health threats. Facing the continuous challenges from “superbugs”, we are running out of effective antibiotics and stepping into the “post-antibiotic era”. This Special Issue, titled “Nanotechnology in Antibacterial Drug Delivery”, aims to explore the transformative role of nanotechnology in enhancing the efficacy and specificity of antibacterial therapies. It is critical to adopt innovative drug delivery systems that can optimize the therapeutic effectiveness while minimizing side effects of currently available antibiotics, as well as novel antibacterials. Nanotechnology offers novel solutions through the development of nanoparticle-based carriers that can improve drug solubility, stability, and targeted delivery to infection sites.

The significance of this research area is underscored by the urgent global health challenges posed by antibiotic resistance. By leveraging nanocarriers, such as liposomes, polymeric nanoparticles, and nanosuspensions, researchers can enhance drug penetration, facilitate controlled release, and promote synergistic effects with existing antibiogram therapies.

We invite original research articles and comprehensive reviews that investigate novel nanotechnology-based approaches to antibacterial drug delivery. Contributions addressing formulation strategies, targeting mechanisms, and the evaluation of therapeutic outcomes are particularly encouraged. Through this Special Issue, we aim to foster collaboration and knowledge exchange among researchers, ultimately advancing the development of effective antibacterial therapies that leverage the potential of nanotechnology.

I look forward to receiving your contributions.

Dr. Sharon Shui Yee Leung
Guest Editor

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Keywords

  • multidrug resistance
  • antibiotic resistance
  • multidrug-resistant bacteria
  • antibiotics
  • antibacterial therapies
  • nanotechnology
  • antibacterial drug delivery
  • nanoparticles
  • targeted delivery
  • controlled release

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Published Papers (2 papers)

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Research

13 pages, 2300 KB  
Article
Eco-Friendly Synthesis of Copper Oxide Nanoparticles Using Geranium Pelargonium x hortorum Leaf Extract and Its Biological Applications
by Alexis Hernández-Guadarrama, Christian Andrea López-Ayuso, Raquel Garza-Hernández, Sarahi García-Carvajal, Ma. Concepción Arenas-Arrocena, A. Berenice Aguilar-Guadarrama and Laura Susana Acosta-Torres
Pharmaceutics 2025, 17(12), 1562; https://doi.org/10.3390/pharmaceutics17121562 - 4 Dec 2025
Abstract
Background/Objectives: The main objective of this study is to report the green synthesis of copper oxide nanoparticles (CuONPs) using an aqueous extract from Pelargonium x hortorum (P. hortorum) leaves. It also aims to evaluate its biological activity as well as [...] Read more.
Background/Objectives: The main objective of this study is to report the green synthesis of copper oxide nanoparticles (CuONPs) using an aqueous extract from Pelargonium x hortorum (P. hortorum) leaves. It also aims to evaluate its biological activity as well as assess its cytotoxic effects on human gingival fibroblasts (HGFs). Methods: Copper oxide nanoparticles (CuONPs) were synthesized through chemical precipitation using an aqueous extract from P. hortorum leaves. These CuONPs were characterized with various techniques, including UV–Vis, Fourier transform infrared (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). Results: The UV–Vis spectrum showed a characteristic absorption peak for CuONPs. FT-IR spectroscopy identified alkoxide and aromatic groups associated with flavonoids and phenolic compounds from P. hortorum. The Cu–O bond was also observed in the same analysis. XRD confirmed that the CuONPs had a monoclinic CuO structure and XPS revealed copper was in the Cu (II) oxidation state bonded to oxygen, consistent with CuO. The nanoparticles were spherical with an average size of 40–53 nm as shown by TEM. The biological activities of CuONPs were tested against Streptococcus mutans (S. mutans) and Candida albicans (C. albicans). The minimum inhibitory concentration (MIC) was 20 µg/mL. Cytotoxicity tests on human gingival fibroblasts (HGFs) after 24 h showed a non-linear, dose-dependent cell viability profile, indicating CuONPs did not exhibit cytotoxicity within the tested range and could even promote cell proliferation at low and intermediate concentrations. Conclusions: This study successfully synthesized CuONPs via a green method, highlighting its potential as a biocompatible antimicrobial and antifungal agent. Full article
(This article belongs to the Special Issue Nanotechnology in Antibacterial Drug Delivery)
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24 pages, 6587 KB  
Article
Salicylic Acid-Mediated Silver Nanoparticle Green Synthesis: Characterization, Enhanced Antimicrobial, and Antibiofilm Efficacy
by Jingqing Zhang, Yuxu Chen, Yuanyu Xu, Zhimin Zhao and Xinjun Xu
Pharmaceutics 2025, 17(4), 532; https://doi.org/10.3390/pharmaceutics17040532 - 18 Apr 2025
Cited by 2 | Viewed by 1455
Abstract
Objectives: Silver nanoparticles (AgNPs) were synthesized via an easy and rapid biogenic synthesis approach, utilizing the dual capabilities of salicylic acid as both a reducing and capping agent. Methods: The characterization of Salicylic Acid-Mediated Silver Nanoparticle (SA-AgNPs) was conducted using a variety of [...] Read more.
Objectives: Silver nanoparticles (AgNPs) were synthesized via an easy and rapid biogenic synthesis approach, utilizing the dual capabilities of salicylic acid as both a reducing and capping agent. Methods: The characterization of Salicylic Acid-Mediated Silver Nanoparticle (SA-AgNPs) was conducted using a variety of techniques, including ultraviolet-visible spectroscopy, dynamic light scattering, scanning electron microscopy combined with energy dispersive X-ray spectroscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, as well as thermogravimetric analysis paired with differential scanning calorimetry. Results: SA-AgNPs demonstrated significant antibacterial properties against both Gram-positive (methicillin-resistant Staphylococcus epidermidis, Staphylococcus aureus, Cutibacterium acnes, methicillin-resistant Staphylococcus aureus) and Gram-negative (Escherichia coli), with minimum inhibitory concentrations (MICs) of 8, 9, 8, 4, and 6 μg/mL, respectively. At a concentration of 32 μg/mL, SA-AgNPs exhibited 99.9% killing efficiency against Escherichia coli (E. coli), Cutibacterium acnes (C. acnes), and methicillin-resistant Staphylococcus aureus (MRSA), within 4, 16, and 12 h, respectively. At the same concentration, SA-AgNPs effectively inhibited 95.61% of MRSA biofilm formation. SA-AgNPs induced the leakage of intracellular macromolecular substances by increasing the membrane permeability, which ultimately caused bacterial apoptosis. Conclusions: Overall, this study presents a fast and environmentally friendly approach for synthesizing SA-AgNPs, with potential applications as nano antibiotics antibacterial coatings for implantable medical devices and wound dressings. Full article
(This article belongs to the Special Issue Nanotechnology in Antibacterial Drug Delivery)
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