Special Issue "Bionanomaterials: Fascinating Materials for Biomedical Applications"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 30 August 2023 | Viewed by 1295

Special Issue Editors

CQM - Centro de Química da Madeira, University of Madeira, Funchal, Portugal
Interests: metal oxide nanoparticles; phytochemistry; diabetes treatment; nanochemistry; bionanomaterials
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 11635 Athens, Greece
Interests: nanostructured biomaterials; polysaccharide-based nanoparticles; hydrogels; biopolymer fluids; small angle scattering techniques
Special Issues, Collections and Topics in MDPI journals
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Marii Skłodowskiej-Curie 34, 41-819 Zabrze, Poland
Interests: polymer chemistry; nanomedicine; self-assembly; liposomes; bioimaging agents

Special Issue Information

Dear Colleagues,

Recently, bionanomaterials are gaining several significant applications in biomedical applications. Conventionally, these bionanomaterials are synthesized via biological organisms such as bacteria, fungi, algae, viruses, and plants. Further, the polymers or phytochemicals extracted from biological organisms are also transformed into nanomaterials, such as cellulose, chitosan, and so on, and are also considered bionanomaterials. In addition, biomolecule-functionalized nanomaterials and nanoformulated biomolecules are also classified under the bionanomaterials category. The organisms by which they are synthesized will eventually influence the properties of the nanomaterials and are beneficial in yielding smaller sized nanomaterials with enhanced stability and less toxicity. These bionanomaterials are recently receiving focus among researchers to be useful in various biomedical applications, including drug delivery, biosensors, tissue engineering, bioimaging, and disease treatment. However, these bionanomaterials are less stable in biofluids for pharmaceutical applications, which eventually affects their ability to be used in large-scale biomedical applications. Thus, biosynthesis approaches must undergo strict optimization for the fabrication of non/less toxic nanoparticles with high biocompatibility, bioavailability and bioreactivity. These bionanomaterials, especially, are under extensive bionanotechnological research to be beneficial as potential theranostic agents, due to their smaller size, distinct morphology and ability to perform as a controlled drug delivery system. Metal, metal oxides, carbon and polymer-based bionanomaterials are the broad classes of biosynthesized nanoparticles, that can be synthesized either via microbial or plant extracts.

Despite such attractive theranostic properties of bionanomaterials, numerous challenges to use them for biomedical applications still exist. This is due to the complexity of the synthesis procedures to fabricate bionanomaterials by balancing their stability and biocompatibility and having no or very low toxicity. Therefore, there is an overarching requirement for the synthesis of novel bionanomaterials and sophisticated characterization of them for exclusive biomedical and theranostic applications with improved biological properties to reach the clinical use criterion.

This research topic intends to collect recent advances that focus on synthesis, functionalization, and biomedical applications of novel bionanomaterials. We are happy to invite potential manuscripts for evaluation and publication in this Special Issue. We welcome studies focused on emerging bionanomaterials, methodologies, theoretical simulations, and their application in biomedical sciences ranging from therapy, drug delivery, bioimaging, tissue engineering and biosensors. Original Research articles, Reviews, and Mini-Reviews on, but not limited to, the following topics can be included:

  • Synthesis and characterization of novel bionanomaterials, such as microbes namely bacteria, fungi, algae, and plants.
  • Synthesis of novel bionanomaterials using agricultural wastes as a source for reducing or stabilizing agents.
  • Synthesis of novel bionanomaterials, such as nanocellulose, nanochitosan, nanolignin, and other nanosized natural biopolymers.
  • Strategies to enhance the properties of bionanomaterials for biomedical applications.
  • Advanced physicochemical characterization of bionanomaterials.
  • Bionanomaterial-based drug formulations for targeted and controlled delivery.
  • Advanced smart and functional bionanomaterials with enhanced drug entrapment efficiency.
  • Functionalization of bionanomaterials for biomedical applications.
  • New applications of bionanomaterials in the biomedical field.
  • Toxicity, reliability, and mechanism of bionanomaterials for biomedical applications.
  • Challenges in the large-scale production of bionanomaterials for biomedical applications.

Dr. Jaison Jeevanandam
Dr. Aristeidis Papagiannopoulos
Dr. Theodore Sentoukas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bionanomaterials
  • bionanotechnology
  • drug delivery systems
  • biomedical applications
  • biocompatibility
  • phytosynthesis
  • microbial synthesis
  • mycosynthesis

Published Papers (1 paper)

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Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications
Pharmaceutics 2023, 15(2), 423; https://doi.org/10.3390/pharmaceutics15020423 - 27 Jan 2023
Viewed by 971
Janus particles have emerged as a novel and smart material that could improve pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two distinct compartments that differ in functionality, physicochemical properties, and morphological characteristics, among other conventional particles. Recently, Janus particles have attracted [...] Read more.
Janus particles have emerged as a novel and smart material that could improve pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two distinct compartments that differ in functionality, physicochemical properties, and morphological characteristics, among other conventional particles. Recently, Janus particles have attracted considerable attention as effective particulate drug delivery systems as they can accommodate two opposing pharmaceutical agents that can be engineered at the molecular level to achieve better target affinity, lower drug dosage to achieve a therapeutic effect, and controlled drug release with improved pharmacokinetics and pharmacodynamics. This article discusses the development of Janus particles for tailored and improved delivery of pharmaceutical agents for diabetes treatment and antimicrobial applications. It provides an account of advances in the synthesis of Janus particles from various materials using different approaches. It appraises Janus particles as a promising particulate system with the potential to improve conventional delivery systems, providing a better loading capacity and targeting specificity whilst promoting multi-drugs loading and single-dose-drug administration. Full article
(This article belongs to the Special Issue Bionanomaterials: Fascinating Materials for Biomedical Applications)
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