Biocompatible and Biodegradable Drug Delivery Systems for the Treatment of Inflammatory Diseases: New Trends and Opportunities
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 149
Special Issue Editors
Interests: hydrogels; pluronics; rheology; amphiphilic block copolymers; liposomes; polymeric nanoparticles
Special Issues, Collections and Topics in MDPI journals
Interests: drug delivery; liposomes; pharmaceutical technology; polymeric micro/nanoparticles; selective targeting
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation plays a key role in the pathogenesis of many acute and chronic diseases, including autoimmune disorders, inflammatory bowel diseases, arthritis and tissue injuries. Although several therapies, such as non-steroidal anti-inflammatory drugs, corticosteroids, immunomodulators, biologics and monoclonal antibodies, are available, conventional systemic administration often results in limited drug accumulation at the target site, reduced efficacy and systemic side effects.
In this context, drug delivery systems made up of biocompatible and biodegradable materials (e.g., polymers, phospholipids and polysaccharides) are gaining attention as effective approaches to improve anti-inflammatory treatments. Materials that are well-tolerated by the body help reduce immune reactions and local irritation, while their ability to be degraded into non-toxic byproducts allows safe clearance, preventing long-term accumulation, an important aspect for chronic therapies. These materials can be employed to obtain drug delivery systems such as hydrogels, nanoparticles, liposomes and micelles with the aim of preserving the drug stability and modulating its release. Beyond safety, the use of biopolymers promotes the development of carriers with tunable physico-chemical properties that allow the targeted and stimuli-responsive delivery of active compounds. This enables adaptation to local physiological conditions, including pH variations, enzymatic activity and inflammation.
This Special Issue aims to highlight recent advances in the design, characterization and pharmaceutical application of biocompatible and biodegradable formulations for anti-inflammatory purposes, including biologics and monoclonal antibodies, with a focus on new trends and emerging opportunities in this field.
We invite submissions of original research articles, short communications and comprehensive reviews.
Dr. Elena Giuliano
Dr. Donato Cosco
Guest Editors
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Keywords
- anti-inflammatory drug delivery formulations
- biocompatible and biodegradable drug delivery systems
- biologics and monoclonal antibodies
- inflammatory diseases
- non-steroidal anti-inflammatory drugs
- stimuli-responsive biomaterials
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