Site-Specific Drug Delivery: Formulation Strategies and Regulatory Challenges

Dear Colleagues,

Site-specific, local drug delivery is valuable as drug exposure is optimized at the target site and minimized systemically, reducing risks for systemic drug interactions and side effects. Depending on the specific site targeted, parenteral, topical, oral, and mucosal drug delivery systems can be used, so a broad range of technologies, dosage forms, excipients, and drug development strategies are employed. Despite recent advances, methods to measure, simulate, and predict local bioavailability and bioequivalence and approaches to establish effective in vitro–in vivo correlations are less developed than for systemic drug delivery methods. In addition, regulatory guidelines regarding the development of these systems and their characterization, including quality tests and new approaches and methodologies, are not as comprehensive as drug developers might wish. This Special Issue aims to support the development of site-specific drug delivery systems by bringing together the latest innovations in the field and providing comprehensive and critical state-of-the-art reviews.

Prof. Dr. Maria Begoña Delgado-Charro
Prof. Dr. Leila Bastos Leal
Guest Editors

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