Pharmaceuticals Based on or Loaded with Natural Products

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 6567

Special Issue Editor


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Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy
Interests: ex-vivo permeation; nanosystems; drug delivery systems; biopolymers; buccal tablets; microparticles; dissolution kinetics
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Special Issue Information

Dear Colleagues,

According to the UN Agenda 2030, several actions (corresponding to 17 Sustainable Development Goals—SDGs) could be taken to act synergistically towards various areas of critical importance for both humanity and the planet. Nowadays, a growing trend is to recover waste, in accordance with a circular economy model, by means of extraction of the loaded or residual natural bioactive compounds (e.g., polyphenols, carotenoids, plant sterols and stanols, anthraquinones, astaxanthin), polymers (e.g., chitosan, hyaluronic acid, pectin), proteins (e.g., collagen, gelatine, fish protein hydrolysate), DNA fractions, lipids, vitamins, etc.  These molecules can be successfully used to produce pharmaceuticals as they can exert a wide range of potent biological activities (e.g., antioxidant, antimicrobic, anti-inflammatory, wound healing, antiaging, anti-hyperpigmentation, photoprotective, chemopreventive, anticancer and immunomodulatory) while also being quite safe.

This Special Issue will collect both scientific research papers and review articles focused on the use of the aforementioned natural products obtained by waste recovery to develop pharmaceutical products useful for several purposes. Dermatologic, transdermic, mucosal and oral formulations as well as micro- and nanotechnology-based delivery systems are welcome. The central natural products could be intended as actives (e.g., polyphenols, DNA fractions, fish protein hydrolysate, etc.) or as natural materials to develop the formulation or the nano- and micro-particulate delivery systems (e.g., gelatin, chitosan, hyaluronic acid, pectin, etc.). Contributions to the expansion of knowledge in this context are of great appeal in the pharmaceutical field while also being in agreement with the current “green” trend.

Dr. Giulia Di Prima
Guest Editor

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Keywords

  • phytochemicals
  • biopolymers
  • antioxidants
  • pharmaceuticals
  • secondary raw materials
  • dermatologic formulations
  • transdermic formulations
  • mucosal formulations
  • oral formulations
  • micro- and nano-delivery systems

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Published Papers (2 papers)

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Research

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23 pages, 2054 KiB  
Article
Characterization and Safety Assessment of a Novel Antioxidant Excipient from Sustainable Recovery of Grape Processing Waste Bentonite Designed to Develop a Thermosensitive Buccal Spray for Oral Cavity Wellness
by Giulia Di Prima, Elena Belfiore, Cecilia La Mantia, Serena Indelicato, Giuseppe Avellone and Viviana De Caro
Pharmaceutics 2024, 16(12), 1612; https://doi.org/10.3390/pharmaceutics16121612 - 19 Dec 2024
Cited by 1 | Viewed by 743
Abstract
Background/Objectives: Nowadays, sustainability efforts focus on extracting natural cosmeceutical ingredients, such as polyphenols, from agri-food waste, for example, black bentonite (BB). The aims of this work were to validate an antioxidant cosmetic ingredient obtained from the waste BB and embed it into an [...] Read more.
Background/Objectives: Nowadays, sustainability efforts focus on extracting natural cosmeceutical ingredients, such as polyphenols, from agri-food waste, for example, black bentonite (BB). The aims of this work were to validate an antioxidant cosmetic ingredient obtained from the waste BB and embed it into an ad hoc designed oromucosal spray intended for oral cavity wellness. Methods: Focusing on sustainability, the study tested PEG200, propylene glycol, and their mixtures as unconventional and green extraction solvents, aligned with a waste-to-market approach. The extracts obtained by maceration were characterized through HPLC-DAD and HPLC-MS analyses, DPPH, Bradford, and Folin–Ciocalteu assays. The best P extract was further subjected to OECD-compliant in vitro validation as novel cosmetic raw material and used to prepare a thermosensitive buccal spray for oral daily care. Results: PEG200 enabled the obtainment of a cost-effective polyphenol-rich extract, which was validated as a safe, high value-added cosmetic secondary raw material. The extract was incorporated into a liquid thermosensitive buccal formulation, able to gel once at body temperature and enhance polyphenol accumulation into the oral mucosae even with short contact times. Conclusions: BB is confirmed as a valuable source of polyphenols, and PEG200 represents an effective extraction solvent leading to a novel functional liquid excipient characterized by an OECD-compliant variegate pool of phenols. The buccal spray then proposed represents a valuable, friendly solution for daily oral care, as it is simple to use, as well as the in vitro and ex vivo tests carried out suggested its effectiveness. Full article
(This article belongs to the Special Issue Pharmaceuticals Based on or Loaded with Natural Products)
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Review

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36 pages, 4769 KiB  
Review
Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions
by Ranjit K. Harwansh, Rohitas Deshmukh, Vijay Pratap Shukla, Dignesh Khunt, Bhupendra Gopalbhai Prajapati, Summya Rashid, Nemat Ali, Gehan M. Elossaily, Vijendra Kumar Suryawanshi and Arun Kumar
Pharmaceutics 2024, 16(9), 1202; https://doi.org/10.3390/pharmaceutics16091202 - 13 Sep 2024
Cited by 7 | Viewed by 5123
Abstract
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, [...] Read more.
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it has been associated with low permeability and bioavailability issues, limiting their efficacy. GA belongs to BCS (Biopharmaceutics classification system) class III (high solubility and low probability). In this context, novel drug delivery approaches played a vital role in resolving these GA issues. Nanocarrier systems help improve drug moiety’s physical and chemical stability by encapsulating them into a lipidic or polymeric matrix or core system. In this regard, researchers have developed a wide range of nanocarrier systems for GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanoparticles, nanostructured lipid carriers, polymer conjugates, etc. In the present review, different search engines like Scopus, PubMed, ScienceDirect, and Google Scholar have been referred to for acquiring recent information on the theme of the work. Therefore, this review paper aims to emphasize several novel drug delivery systems, patents, and clinical updates of GA. Full article
(This article belongs to the Special Issue Pharmaceuticals Based on or Loaded with Natural Products)
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