Natural Products and Their Bioinspired Nanodelivery Systems for Immune Microenvironment Modulation
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: 31 May 2027
Special Issue Editor
Interests: natural products; bioinspired nanodelivery; nanomedicine; controlled release; immune microenvironment; extracellular vesicles; microneedles; tumor immune microenvironment; inflammatory signaling
Special Issue Information
Dear Colleagues,
Natural products, including plant-derived compounds, microbial metabolites, marine natural products, and traditional medicine-derived formulations, provide valuable therapeutic resources for cancer, inflammatory diseases, infections, metabolic disorders, and dermatological conditions. Many of these bioactive agents can modulate immune microenvironments by regulating macrophage polarization, cytokine networks, microbiome homeostasis, and tumor-associated immune responses. However, their pharmaceutical development and clinical translation are often limited by their poor aqueous solubility, chemical instability, low permeability, rapid metabolism, limited bioavailability, insufficient tissue targeting, and unpredictable pharmacokinetic profiles.
Bioinspired nanodelivery systems, including nanoliposomes, nano-emulsions, micelles, polymeric nanoparticles, hydrogels, extracellular vesicles, bacterial vesicle-inspired platforms, biomimetic nanoparticles, and microneedles, offer promising strategies to improve formulation performance, enhance biological barrier penetration, enable controlled or targeted release, and increase therapeutic efficacy.
This Special Issue aims to highlight the recent progress in pharmaceutical strategies for natural products and their bioinspired nanodelivery systems. We welcome original research and review articles that focus on formulation design, delivery mechanisms, pharmacokinetics, pharmacodynamics, safety evaluation, and translational applications. Topics of interest include, but are not limited to, natural product-based immunomodulation, bioinspired nanocarriers, extracellular vesicle-based delivery, microneedle-assisted delivery, macrophage polarization, tumor immune microenvironment remodeling, skin inflammation, microbiome regulation, antimicrobial therapy, barrier repair, and inflammation-associated disease progression.
Dr. Hong Zhou
Guest Editor
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Keywords
- nanodelivery systems
- formulation design
- pharmacokinetics
- pharmacodynamics
- immunomodulation
- natural products
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