Advanced Pharmaceutical Excipients Used in Solid Dosage Forms

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 518

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
Interests: liquisolid systems; co-processed excipients; melt granulation; hot melt coating; multiparticulates; fluid bed; solid dosage forms
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
Interests: quality by design; oral drug delivery; solid dosage forms; artificial intelligence; modified drug release; multiparticulates; process optimization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Solid dosage forms are the most common dosage forms on the market and are preferred by both manufacturers and patients. The importance of excipients, which usually account for the majority of the total mass of a drug product, is well known and is related to various aspects, including the manufacturability, stability and (bio)performance of the drug product. Recent advances and new trends in solid dosage form manufacturing and formulation are targeting advanced and highly functional excipients. Some of the key trends in solid dosage form manufacturing are related to improving the speed of manufacturing equipment, the application of more cost-effective and environmentally friendly technologies and the increasing interest in continuous processing, all of which require improvements in excipient functionality and lot-to-lot consistency. On the other hand, new formulation approaches that address the major challenge posed by the increasing number of poorly soluble APIs, or the need to improve patient compliance through patient-tailored solid dosage forms, further highlight the need for new, multifunctional excipients.

This Special Issue focuses on recent advances in the development of excipients with high functionality for solid dosage forms and the methods used to characterize them.

Dr. Ivana Aleksić
Prof. Dr. Jelena Djuris
Guest Editors

Manuscript Submission Information

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Keywords

  • solid dosage forms
  • co-processed excipients
  • mesoporous materials
  • multifunctional excipients
  • directly compressible
  • high-functionality excipients
  • bioavailability enhancement
  • continuous processing
  • patient compliance
  • sustainability
  • poor solubility

Published Papers (1 paper)

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Review

18 pages, 1370 KiB  
Review
An Overview of Hydrothermally Synthesized Titanate Nanotubes: The Factors Affecting Preparation and Their Promising Pharmaceutical Applications
by Ranim Saker, Hadi Shammout, Géza Regdon, Jr. and Tamás Sovány
Pharmaceutics 2024, 16(5), 635; https://doi.org/10.3390/pharmaceutics16050635 - 9 May 2024
Viewed by 358
Abstract
Recently, titanate nanotubes (TNTs) have been receiving more attention and becoming an attractive candidate for use in several disciplines. With their promising results and outstanding performance, they bring added value to any field using them, such as green chemistry, engineering, and medicine. Their [...] Read more.
Recently, titanate nanotubes (TNTs) have been receiving more attention and becoming an attractive candidate for use in several disciplines. With their promising results and outstanding performance, they bring added value to any field using them, such as green chemistry, engineering, and medicine. Their good biocompatibility, high resistance, and special physicochemical properties also provide a wide spectrum of advantages that could be of crucial importance for investment in different platforms, especially medical and pharmaceutical ones. Hydrothermal treatment is one of the most popular methods for TNT preparation because it is a simple, cost-effective, and environmentally friendly water-based procedure. It is also considered as a strong candidate for large-scale production intended for biomedical application because of its high yield and the special properties of the resulting nanotubes, especially their small diameters, which are more appropriate for drug delivery and long circulation. TNTs’ properties highly differ according to the preparation conditions, which would later affect their subsequent application field. The aim of this review is to discuss the factors that could possibly affect their synthesis and determine the transformations that could happen according to the variation of factors. To fulfil this aim, relevant scientific databases (Web of Science, Scopus, PubMed, etc.) were searched using the keywords titanate nanotubes, hydrothermal treatment, synthesis, temperature, time, alkaline medium, post treatment, acid washing, calcination, pharmaceutical applications, drug delivery, etc. The articles discussing TNTs preparation by hydrothermal synthesis were selected, and papers discussing other preparation methods were excluded; then, the results were evaluated based on a careful reading of the selected articles. This investigation and comprehensive review of different parameters could be the answer to several problems concerning establishing a producible method of TNTs production, and it might also help to optimize their characteristics and then extend their application limits to further domains that are not yet totally revealed, especially the pharmaceutical industry and drug delivery. Full article
(This article belongs to the Special Issue Advanced Pharmaceutical Excipients Used in Solid Dosage Forms)
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