Cocrystal Engineering in Pharmaceutical Formulations
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 29
Special Issue Editors
Interests: crystal engineering; formulation development; controlled release
Special Issue Information
Dear Colleagues,
The Pharmaceutics journal is pleased to announce this Special Issue, titled "Cocrystal Engineering in Pharmaceutical Formulations." Pharmaceutical cocrystals have emerged as a versatile platform for addressing long-standing challenges in small-molecule drug development, particularly the poor solubility, limited permeability, and suboptimal bioavailability that affect a majority of new chemical entities. Evolving from early serendipitous discoveries, cocrystal engineering has matured into a powerful approach that enhances drug performance while also preserving the intrinsic pharmacophore. Beyond solubility and dissolution improvements, cocrystals have demonstrated benefits in taste masking, stability enhancement, tabletability, and controlled release. These advances have already culminated in several commercial successes, including Entresto, Suglat, Steglatro, and Seglentis, underscoring regulatory recognition and therapeutic impact.
This Special Issue will focus on the design, synthesis, characterization, and application of pharmaceutical cocrystals. We welcome contributions on efficient cocrystal screening, drug–drug cocrystal design, mechanistic studies on structure–property relationships, and computational or data-driven approaches for cocrystal structure prediction. Research on scale-up strategies, regulatory and intellectual property aspects, as well as case studies bridging laboratory innovation to clinical and commercial translation, are of particular interest.
We invite researchers and pharmaceutical scientists to contribute original research and comprehensive reviews exploring the design, development, and application of cocrystals in pharmaceutical formulations for improved drug performance and therapeutic outcomes.
We look forward to receiving your contributions.
Dr. Chenguang Wang
Prof. Dr. Changquan Calvin Sun
Guest Editors
Manuscript Submission Information
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Keywords
- cocrystal engineering
- pharmaceutical cocrystals
- solubility enhancement
- bioavailability
- polymorphism
- coformer selection
- stability
- structure prediction
- drug formulation
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