Study on Bacterial Biofilm-Targeted Smart Drug Delivery System

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (10 June 2024) | Viewed by 179

Special Issue Editors

E-Mail Website
Guest Editor
Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
Interests: nanoparticle synthesis; ROS science; cancer treatment; dental research; biofilms

E-Mail Website
Guest Editor
Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
Interests: oral biofilm; early childhood caries; candida albicans; streptococcus mutans

Special Issue Information

Dear Colleagues,

Bacterial biofilm formation is involved in the pathogenesis of many diseases and is responsible for up to 80% of all human bacterial infections. Biofilms are complex, multicellular communities of bacteria that adhere to surfaces and are highly protected by a self-produced extracellular matrix. The matrix contributes to the high virulence and tolerance of biofilms to antibiotics by restricting drug penetration, diffusion and limiting the retention of antibiotics. The persistent nature of these biofilms, coupled with their inherent resistance to traditional antimicrobial therapies, underscores a pressing clinical challenge—these biofilms often evade eradication, leading to recurrent treatment failures. In response to this urgent issue, there is a growing emphasis on the exploration of smart drug carriers. These innovative platforms are being investigated for their potential to effectively penetrate biofilms, thereby enhancing the efficacy of antimicrobials while simultaneously minimizing the adverse effects associated with current treatments. This Special Issue aims to serve as an esteemed forum for the congregation of distinguished scientists globally, fostering an environment of collaborative exploration and innovation. By presenting a convergence of groundbreaking research and cutting-edge strategies, we aspire to catalyze advancements in combating persistent bacterial infections. We are seeking submissions of both review and original research articles that contribute novel insights and empirical findings related to the targeted delivery of drugs to bacterial biofilms.

We look forward to receiving your contributions.

Dr. Nil Kanatha Pandey
Dr. Zhenting Xiang
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • drug delivery system
  • antibiofilm therapy
  • smart carriers
  • biomaterials
  • triggered drug release
  • bacterial biofilms

Published Papers

There is no accepted submissions to this special issue at this moment.
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