Multifunctional Hydrogels for Controlled Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2222

Special Issue Editor

Special Issue Information

Dear Colleagues,

Multifunctional hydrogels have shown great potential as drug delivery platforms due to their unique properties, such as their high water content, biocompatibility, and adjustable mechanical strength. These hydrogels can be designed to respond to various external stimuli (such as temperature, pH, and light), allowing for controlled and targeted drug release. Additionally, multifunctional hydrogels can enhance therapeutic effects by loading multiple drugs, providing sustained release and protecting drug activity.

In recent years, significant progress has been made in the intelligent and functional design of hydrogels, showing broad application prospects in fields such as cancer treatment, chronic disease management, and tissue engineering. The diverse applications of hydrogels not only improve treatment effectiveness and precision but also reduce drug side effects and increase patient compliance. Therefore, multifunctional hydrogels are expected to play an increasingly important role in the future of medicine.

Dr. Cheng Hu
Guest Editor

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Keywords

  • multifunctional hydrogels
  • drug delivery
  • biomedical applications
  • targeted release
  • therapeutic effects

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Published Papers (1 paper)

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Review

20 pages, 3731 KiB  
Review
Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment
by Juan Cao, Bo Wu, Ping Yuan, Yeqi Liu and Cheng Hu
Pharmaceutics 2024, 16(12), 1571; https://doi.org/10.3390/pharmaceutics16121571 - 9 Dec 2024
Cited by 1 | Viewed by 1918
Abstract
Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer a minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly to the epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various [...] Read more.
Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer a minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly to the epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due to their excellent biocompatibility, high drug-loading capacity, and tunable drug-release properties. This review systematically examines the matrix materials and fabrication methods of HMN systems, highlighting advancements in natural and synthetic polymers, and explores their applications in treating conditions such as wound healing, hair loss, cardiovascular diseases, and cancer. Furthermore, the potential of HMNs for disease diagnostics is discussed. The review identifies key challenges, including limited mechanical strength, drug-loading efficiency, and lack of standardization, while proposing strategies to overcome these issues. With the integration of intelligent design and enhanced control over drug dosage and safety, HMNs are poised to revolutionize transdermal drug delivery and expand their applications in personalized medicine. Full article
(This article belongs to the Special Issue Multifunctional Hydrogels for Controlled Drug Delivery)
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