Polymer-Based Nanotechnology Delivery Systems for Nucleic Acids
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 198
Special Issue Editor
Interests: polymer-based nanopartle; delivery systems; nucleic acids; targeted delivery; specific delivery; therapeutic nucleic acids (TNAs); cancers; vaccines; cardiovascular diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The rapid advancement of nucleic acid-based therapeutics has opened transformative opportunities in the treatment of cancers, infectious diseases, cardiovascular disorders, and genetic conditions. Despite these breakthroughs, the clinical translation of therapeutic nucleic acids (TNAs)—including siRNA, miRNA, mRNA, plasmid DNA, antisense oligonucleotides, and gene editing components—remains limited by challenges in stability, targeted delivery, cellular uptake, endosomal escape, and controlled release.
Polymer-based nanotechnology offers a versatile and powerful platform to overcome these barriers. Engineered polymeric nanoparticles, micelles, dendrimers, polyplexes, and hybrid nanostructures can enhance the delivery efficiency, biocompatibility, and precision of nucleic acid therapeutics. Recent advances in biodegradable polymers, stimuli-responsive systems, and multifunctional nanocarriers have further accelerated innovation in this field.
This Special Issue invites cutting-edge research and comprehensive reviews that advance the science, design, and application of polymer-based delivery systems for nucleic acids. Submissions may address, but are not limited to, the following:
- Polymer-based nanoparticles and nanocarriers for siRNA, miRNA, mRNA, or DNA delivery;
- Biodegradable, stimuli-responsive, or targeted polymeric systems;
- Therapeutic nucleic acids (TNAs) for cancer therapy, vaccines, cardiovascular diseases, and other indications;
- Polyplex formation, stability, and intracellular trafficking mechanisms;
- Hybrid polymer–lipid, polymer–inorganic, or polymer–biomolecule delivery systems;
- Translational studies, in vivo evaluation, and safety/toxicology profiles;
- Innovative manufacturing, scale-up challenges, and regulatory considerations.
We welcome original research articles and comprehensive reviews that explore novel delivery strategies, mechanistic insights, or clinical translation potential. This Special Issue aims to serve as a platform for researchers to share scientific advances that push the frontiers of nucleic acid therapeutics and polymer nanotechnology.
Prof. Dr. Johnny (Changyi) Chen
Guest Editor
Manuscript Submission Information
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Keywords
- polymer-based nanoparticles
- nucleic acid delivery systems
- therapeutic nucleic acids (TNAs)
- cancers
- vaccines
- cardiovascular diseases
- polymeric micelles, dendrimers, polyplexes
- mRNA and gene editing delivery approaches
- translational and preclinical studies
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