Innovative Strategies for Precision Intervention in Brain Diseases
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 35
Special Issue Editors
Interests: brain tumor prevention treatments; nanomedicines crossing the blood-brain barrier; targeted therapy for brain tumors; treatment of neurodegenerative conditions; nanotherapy and the effects of air pollution on the brain
Interests: biopharmaceutics; nanotechnology; molecular targeting; antisense oligonucleotides; sirna and peptide delivery
Special Issue Information
Dear Colleagues,
The number of neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's (PD) disease, is growing with the aging of the population. Primary and metastatic malignant and benign brain tumors are pathologies where the treatment results have not significantly improved during the last 50 years.
An effective treatment of pathological brain conditions requires “new” approaches with “old” rules. The “new” strategies are novel classes of medicines, selection of the molecular targets and/or pathways, Artificial Intelligence (AI) analyses of databases, and combination approaches for effective treatment for each individual patient. Among the “old” rules, when the brain is involved, number one is drug delivery through biological barriers, including the blood–brain barrier (BBB), where the neuro-drugs should be effectively delivered to the brain to treat it systemically, in the case of neurodegenerative conditions (AD and PD), or to the pathological site when primary or metastatic brain tumors are diagnosed. The second obstacle is to overcome neurotoxicity to preserve the brain’s complex structure and functions.
This Special Issue, titled “Innovative Strategies for Precision Intervention in Brain Diseases”, aims to collect original research articles and reviews concerning the synthesis of various multifunctional nanomaterials, pharmaceutical characterization studies, and in vitro/in vivo novel treatments of Central Nervous System (CNS) disorders and brain tumor studies. In addition, work aiming to increase knowledge about the synthesis of various nanomaterials and clinical treatments is also welcome.
Prof. Dr. Julia Y. Ljubimova
Prof. Dr. Tamara Minko
Guest Editors
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Keywords
- blood–brain barrier
- nanomedicine drug delivery
- neurodegenerative diseases
- brain tumors
- precision medicine
- CNS disorders
- multifunctional nanomaterials
- personalized therapy
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