Targeted Nanoradiopharmaceuticals as a Molecular Approach for Theranostic Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 1289

Special Issue Editors


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Guest Editor
Department of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico
Interests: radiopharmaceutical sciences; targeted radiotherapy; theranostics; molecular imaging; combined therapies; nanoradiopharmaceuticals; radiolabeled nanoparticles

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Guest Editor
Facultad de Química, Universidad Autónoma del Estado de México, Paseo Tollocan S/N, Toluca 50120, Mexico
Interests: drug delivery; nanoparticles; therapy; imaging; theranostics; radiolabeled nanoparticles

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Guest Editor
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35138 Padova, Italy
Interests: radiopharmaceutical chemistry; targeted radionuclide therapy; molecular imaging; PET and SPECT preclinical imaging; radiopharmacokinetics; endoradiotherapy; dosimetric studies
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Special Issue Information

Dear Colleagues,

The field of nanoparticle-based radiopharmaceuticals holds great promise for the diagnosis and treatment of cancer and other diseases. Nanoparticles can be used to deliver radionuclides, cytotoxic drugs, or imaging agents, offering multimodal platforms as integral approaches in the field of nuclear medicine. This Special Issue aims to explore strategies to improve targeting efficiency and to develop methods for encapsulating components that ensure safety and efficacy, in order to propose new approaches for the clinical translation phase.

The sub-topics to be covered within this Special Issue are as follows:

  • Radiopharmaceuticals based on organic nanoparticles for combined therapies;
  • Radiopharmaceuticals based on metallic nanoparticles for theranostic purposes;
  • Radiolabeled nanoparticles for diagnosis or therapy.

Dr. Blanca Ocampo García
Dr. Enrique Morales-Avila
Dr. Laura Melendez-Alafort
Guest Editors

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Keywords

  • drug delivery
  • nanoparticles
  • therapy
  • imaging
  • theranostics
  • radiolabeled nanoparticles

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Published Papers (1 paper)

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Review

19 pages, 3262 KiB  
Review
An Insight to Nanoliposomes as Smart Radiopharmaceutical Delivery Tools for Imaging Atherosclerotic Plaques: Positron Emission Tomography Applications
by Reabetswe Sebatana, Kahwenga D. Kudzai, Allan Magura, Amanda Mdlophane, Jan Rijn Zeevaart, Mike Sathekge, Maryke Kahts, Sipho Mdanda and Bwalya Angel Witika
Pharmaceutics 2025, 17(2), 240; https://doi.org/10.3390/pharmaceutics17020240 - 12 Feb 2025
Viewed by 840
Abstract
Atherosclerosis is a chronic progressive disease which is known to cause acute cardiovascular events as well as cerebrovascular events with high mortality. Unlike many other diseases, atherosclerosis is often diagnosed only after an acute or fatal event. At present, the clinical problems of [...] Read more.
Atherosclerosis is a chronic progressive disease which is known to cause acute cardiovascular events as well as cerebrovascular events with high mortality. Unlike many other diseases, atherosclerosis is often diagnosed only after an acute or fatal event. At present, the clinical problems of atherosclerosis mainly involve the difficulty in confirming the plaques or identifying the stability of the plaques in the early phase. In recent years, the development of nanotechnology has come with various advantages including non-invasive imaging enhancement, which can be studied for the imaging of atherosclerosis. For targeted imaging and atherosclerosis treatment, nanoliposomes provide enhanced stability, drug administration, extended circulation, and less toxicity. This review discusses the current advances in the development of tailored liposomal nano-radiopharmaceutical-based techniques and their applications to atherosclerotic plaque diagnosis. This review further highlights liposomal nano-radiopharmaceutical localisation and biodistribution—key processes in the pathophysiology of atherosclerosis. Finally, this review discusses the direction and future of liposomal nano-radiopharmaceuticals as a potential clinical tool for the assessment and diagnosis of atherosclerotic plaque. Full article
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