Special Issue "Pathophysiology of Autoimmune Diseases"
A special issue of Pathophysiology (ISSN 1873-149X).
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 20119
Interests: autoimmunity; autoimmune diseases; aetiology; pathogenesis; models; experimental therapy; geoepidemiology; adjuvants; ASIA-syndrome; dysautonomia; infertility; adverse effects of checkpoint inhibitor therapy; functional antibodies; physiologic autoimmunity; autoimmunity and microbiota; autoimmunity and cancer; autoimmunity and vaccines; COVID-19 and autoimmunity
Special Issues, Collections and Topics in MDPI journals
Interests: clinical immunology; autoimmune diseases; rheumatology diseases; lupus
Special Issues, Collections and Topics in MDPI journals
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Special Issue in International Journal of Molecular Sciences: Autoimmunity and COVID-19
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Special Issue in Diagnostics: COVID-19, Post-COVID and Autoimmunity
The development of autoimmune diseases is multifactorial and subordinated to laws of the additive polygenetic inheritance with the threshold effect from the side of a whole series of natural and sociocultural anthropogenic epigenetic factors, sometimes even including iatrogenic ones. Since the autoimmune diseases of different organs and systems have much in common considering their pathophysiology, clinical manifestations, as well as their prevention and treatment approaches, a new interdisciplinary branch of medicine—autoimmunology—has formed recently in front of our eyes. About 90 autoimmune diseases have been described, which implicate all organs and systems and belong to the sphere of all medical specializations. Autoimmune diseases’ morbidity and mortality steadily grow in all developed countries. There is strong evidence for existence of autoimmune/autoinflammatory links in the pathogenesis of severe COVID-19 cases of current global pandemic. In spite of the successes in the study of the etiology, pathogenesis, and models of many autoimmune illnesses, the nature of the general disturbances, which underlie various particular forms of autoimmune disorders, remains the urgent object of scientific studies and discussions. At the same time, practical healthcare worldwide experiences the utmost need for target prophylaxis and effective modalities of autoimmune disorder treatment, and minimization of their adverse effects. The evolution of nature and development of civilization set many new challenges for biomedical science and for healthcare systems, including new risk factors of autoimmune diseases; hence, there is a great possibility that the 21st century will turn into an aeon of autoimmunity.
This trend may in future change the whole philosophy of clinical medicine. Currently, it is believed that autoimmune diseases are induced through a combination of genetic and environmental factors. The genotype distinguishes individuals who may possess inherited characteristics, making their immune system hyperactive (e.g., HLA DRb1). The environmental factors include, first of all, those compounds that have an adjuvant effect (from the Latin word adjuvare—“to help or aid”). This means that such a factor may enhance immune responses modifying the immunoregulating interactions. In the presence of primary individual hereditary predisposition, pathological autoimmunity can manifest differently under the influence of various exogenous adjuvants or, vice versa—immunosuppressive factors—interplaying at different life periods of a concrete person, while autoimmune disorders in the human body seem to flow from one nosological entity to another, keeping a similar background which is a principle known as the “kaleidoscope of autoimmunity”. The Special Issue of Pathophysiology dedicated to autoimmunity problems aims to attract both researchers and clinicians of various specialties and contributions by leading scholars of this scientific area.
Dr. Leonid Churilov
Prof. Yehuda Shoenfeld
Manuscript Submission Information
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- autoimmune diseases
- experimental therapy
- ASIA syndrome
- adverse effects of checkpoint inhibitor therapy
- functional antibodies
- physiologic autoimmunity
- autoimmunity and microbiota
- autoimmunity and cancer
- autoimmunity and vaccines
- COVID-19 and autoimmunity cardiovascular diseases
- blood pressure
- nitric oxide
- polyphenolic substances